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Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors

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Abstract

Nod-like receptors (NLRs) have gained attention in recent years because of the ability of some family members to assemble into a multimeric protein complex known as the inflammasome. The role of NLRs and the inflammasome in regulating innate immunity against bacterial pathogens has been well studied. However, recent studies show that NLRs and inflammasomes also play a role during infections caused by protozoan parasites, which pose a significant global health burden. Herein, we review the diseases caused by the most common protozoan parasites in the world and discuss the roles of NLRs and inflammasomes in host immunity against these parasites.

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Acknowledgments

We thank Drs. Vani J. Shanker and Cherise M. Guess of St. Jude Children’s Research Hospital’s Department of Scientific Editing for her help with critical editing of the manuscript. We also thank Drs. Farrah Phillips, Si Ming Man and Ankit Malik for their critical reading of the manuscript. PG is a postdoctoral fellow supported by the Paul Barrett Endowed Fellowship from St. Jude Children’s Research Hospital. This work was supported in part by grants from the National Institute of Health (Grants AR056296, CA163507, and AI101935) and American Lebanese Syrian Associated Charities to T-D.K.

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  1. Department of Immunology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA

    Prajwal Gurung & Thirumala-Devi Kanneganti

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  1. Prajwal Gurung
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  2. Thirumala-Devi Kanneganti
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Correspondence to Thirumala-Devi Kanneganti.

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Gurung, P., Kanneganti, TD. Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors. Cell. Mol. Life Sci. 73, 3035–3051 (2016). https://doi.org/10.1007/s00018-016-2212-3

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  • DOI: https://doi.org/10.1007/s00018-016-2212-3

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