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Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

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Abstract

The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P < 0.01) in normal rats and shows around 17.7% (P < 0.01) and 17.1% fall on blood glucose levels at 0–300 and 0–1440 min, respectively, on streptozotocin-induced diabetic rats at an oral dose of 250 mg/Kg body weight. The extract has also been found to improve around 26.7% (P < 0.01) glucose intolerance on 14th day post treatment in high fructose fed streptozotocin-induced diabetic rats. The extract was also found to have antidyslipidemic activity as evident by 21.04% (P < 0.01) decline in serum triglycerides, 22.7% (P < 0.01) decline in total serum cholesterol, and 16.9% of decline in serum LDL-C, respectively, along with 12.2% (P < 0.05) increase in serum HDL-C on high fat diet fed male Syrian golden hamster. The extract was also found inhibitory to eye lens aldose reductase (EC 1.1.1.21) with IC50 value of 7.07 μg/ml as compared to the standard AR inhibiting compound Quercetin which showed IC50 2.35 μg/ml. The extract was also found inhibitory to α-glucosidase with IC50 value of 100 μg/ml as compared to known drug Acarbose which showed IC50 of around 25 μg/ml.

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Acknowledgment

The authors gratefully acknowledge to CSIR, New Delhi for providing financial support to carry out this work in the form of network project (NWP-0032).

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  1. Divisions of Biochemistry and Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, 226001, India

    Rohit Srivsatava, Swayam Prakash Srivastava, Natasha Jaiswal, Akansha Mishra, Rakesh Maurya & Arvind Kumar Srivastava

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  1. Rohit Srivsatava
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  2. Swayam Prakash Srivastava
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  3. Natasha Jaiswal
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Correspondence to Swayam Prakash Srivastava.

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Srivsatava, R., Srivastava, S.P., Jaiswal, N. et al. Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models. Med Chem Res 20, 1656–1666 (2011). https://doi.org/10.1007/s00044-010-9483-2

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