Background
Diagnostic approach
PTP and clinical likelihood of CAD
Diagnostic tests
Test | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | +LR | −LR |
---|---|---|---|---|
Anatomically significant CAD | ||||
Exercise ECG | 58 (46–69) | 62 (54–69) | 1.53 (1.21–1.94) | 0.68 (0.49–0.93) |
Stress echo | 85 (80–89) | 82 (72–89) | 4.67 (2.95–7.41) | 0.18 (0.13–0.25) |
Coronary CTAb | 96 (93–98) | 82 (75–87) | 8.9 (6.1–13.5) | 0.022 (0.01–0.04) |
SPECT | 87 (83–90) | 70 (63–76) | 2.88 (2.33–3.56) | 0.19 (0.15–0.24) |
PET | 90 (78–96) | 85 (78–90) | 5.87 (3.40–10.15) | 0.12 (0.05–0.29) |
Stress CMR | 90 (83–94) | 80 (69–88) | 4.54 (2.37–8.72) | 0.13 (0.07–0.24) |
Functionally significant CAD | ||||
Coronary CTA | 93 (89–96) | 53 (37–68) | 1.97 (1.28–3.03) | 0.13 (0.06–0.25) |
SPECT | 73 (62–82) | 83 (71–90) | 4.21 (2.62–6.76) | 0.33 (0.24–0.46) |
PET | 89 (82–93) | 85 (81–88) | 6.04 (4.29–8.51) | 0.13 (0.08–0.22) |
Stress CMR | 89 (85–92) | 87 (83–91) | 7.10 (5.07–9.95) | 0.13 (0.09–0.18) |