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Strahlentherapie und Onkologie

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01.04.2013 | Original article

Radiotherapy for calcaneodynia

Results of a single center prospective randomized dose optimization trial

verfasst von: PD Dr. O.J. Ott, C. Jeremias, U.S. Gaipl, B. Frey, M. Schmidt, R. Fietkau

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 4/2013

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Abstract

Purpose

The aim of this work was to compare the efficacy of two different dose fractionation schedules for radiotherapy of patients with calcaneodynia.

Patients and methods

Between February 2006 and April 2010, 457 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received radiotherapy using the orthovoltage technique. One radiotherapy series consisted of 6 single fractions/3 weeks. In case of insufficient remission of pain after 6 weeks a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. Endpoint was pain reduction. Pain was measured before, immediately after, and 6 weeks after radiotherapy using a visual analogue scale (VAS) and a comprehensive pain score (CPS).

Results

The overall response rate for all patients was 87 % directly after and 88 % 6 weeks after radiotherapy. The mean VAS values before, immediately after, and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 65.5 ± 22.1 and 64.0 ± 20.5 (p = 0.188), 34.8 ± 24.7 and 39.0 ± 26.3 (p = 0.122), and 25.1 ± 26.8 and 28.9 ± 26.8 (p = 0.156), respectively. The mean CPS before, immediately after, and 6 weeks after treatment was 10.1 ± 2.7 and 10.0 ± 3.0 (p = 0.783), 5.6 ± 3.7 and 6.0 ± 3.9 (p = 0.336), 4.0 ± 4.1 and 4.3 ± 3.6 (p = 0.257), respectively. No statistically significant differences between the two single dose trial arms for early (p = 0.216) and delayed response (p = 0.080) were found.

Conclusion

Radiotherapy is an effective treatment option for the management of calcaneodynia. For radiation protection reasons, the dose for a radiotherapy series is recommended not to exceed 3–6 Gy.

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Titel: Radiotherapy for calcaneodynia
Results of a single center prospective randomized dose optimization trial
verfasst von: PD Dr. O.J. Ott
C. Jeremias
U.S. Gaipl
B. Frey
M. Schmidt
R. Fietkau
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 4/2013
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0256-3

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Results of a single center prospective randomized dose optimization trial

Abstract

Purpose

Patients and methods

Results

Conclusion

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