Skip to main content
Erschienen in: Strahlentherapie und Onkologie 1/2014

01.01.2014 | Original article

Patterns of care in patients with cervical cancer 2012

Results of a survey among German radiotherapy departments and out-patient health care centers

verfasst von: S. Marnitz, M.D., C. Köhler, M.D., A. Rauer, A. Schneider, M.D., M.P.H., V. Budach, M.D., A. Tsunoda, M.D., M. Mangler, M.D.

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 1/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Platinum-based primary or adjuvant chemoradiation is the treatment of choice for patients with cervical cancer. However, despite national guidelines and international recommendations, many aspects in diagnosis, therapy, and follow-up of patients with cervical cancer are not based on valid data.

Methods

To evaluate the current patterns of care for patients with cervical cancer in Germany, a questionnaire with 25 items was sent to 281 radiooncologic departments and out-patient health care centers.

Results

The response rate was 51 %. While 87 % of institutions treat 0–25 patients/year, 12 % treat between 26 and 50 and only 1 % treat more than 50 patients/year. In 2011, the stage distribution of 1,706 treated cervical cancers were IB1, IB2, IIA, IIB, IIIA/IIIB, and IV in 11, 12, 11, 22, 28, and 16 %, respectively. CT (90 %) and MRI (86 %) are mainly used as staging procedures in contrast to PET-CT with 14 %. Interestingly, 27 % of institutions advocate surgical staging prior to chemoradiation. In the majority of departments 3D-based (70 %) and intensity-modulated radiotherapy (76 %) are used for percutaneous radiation, less frequently volumetric arc techniques (26 %). Nearly all colleagues (99.3 %) apply conventional fractioning of 1.8–2 Gy for external-beam radiotherapy, in 19 % combined with a simultaneous integrated boost. Cisplatinum mono is used as a radiosensitizer with 40 mg/m2 weekly by 90 % of radiooncologists. For boost application in the primary treatment, HDR (high-dose rate) brachytherapy is the dominant technique (84 %). In patients after radical hysterectomy pT1B1/1B2, node negative and resection in sound margins adjuvant chemoradiation is applied due to the occurrence of 1–4 other risk factors in 16–97 %. There is a broad spectrum of recommended primary treatment strategies in stages IIB and IVA.

Conclusion

Results of the survey underline the leading role but also differences in the use of chemoradiation in the treatment of cervical cancer patients in Germany.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Rose PG, Bundy BN, Watkins EB et al (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144–1153PubMedCrossRef Rose PG, Bundy BN, Watkins EB et al (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144–1153PubMedCrossRef
2.
Zurück zum Zitat Whitney CW, Sause W, Bundy BN et al (1999) Randomised comparison of fluorouracil plus cisplatin versus hydroxyurea in stage IIB/IVA in carcinoma of the cervix. J Clin Oncol 17:1339–1348PubMed Whitney CW, Sause W, Bundy BN et al (1999) Randomised comparison of fluorouracil plus cisplatin versus hydroxyurea in stage IIB/IVA in carcinoma of the cervix. J Clin Oncol 17:1339–1348PubMed
3.
Zurück zum Zitat Pearcey R, Brundage M, Drouin P et al (2002) Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 20:966–972PubMedCrossRef Pearcey R, Brundage M, Drouin P et al (2002) Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 20:966–972PubMedCrossRef
4.
Zurück zum Zitat Chemoradiation for cervical cancer meta-analysis collaboration (2008) Reducing uncertainties about the effect of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol 26:5802–5812CrossRef Chemoradiation for cervical cancer meta-analysis collaboration (2008) Reducing uncertainties about the effect of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol 26:5802–5812CrossRef
5.
Zurück zum Zitat National Comprehensive Cancer Network (2013) http://www.NCCN.org. Accessed 27 June 2013 National Comprehensive Cancer Network (2013) http://​www.​NCCN.​org.​ Accessed 27 June 2013
6.
Zurück zum Zitat S2-Leitlinie zur Diagnostik und Therapie des Zervixkarzinoms der Kommission Uterus der AGO vom 07.12.2006, Überarbeitung 2008 S2-Leitlinie zur Diagnostik und Therapie des Zervixkarzinoms der Kommission Uterus der AGO vom 07.12.2006, Überarbeitung 2008
7.
Zurück zum Zitat Beck T, Sukumvanich P, Rubatt J et al (2010) Impact of the National Cancer Institute’s clinical announcement on cervical cancer survival. Gynecol Oncol 116(Suppl1):S2–S169CrossRef Beck T, Sukumvanich P, Rubatt J et al (2010) Impact of the National Cancer Institute’s clinical announcement on cervical cancer survival. Gynecol Oncol 116(Suppl1):S2–S169CrossRef
8.
Zurück zum Zitat Krebs in Deutschland (2007/2008) 8. Ausgabe. Robert Koch-Institut (ed) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. (ed). Berlin, 2012 Krebs in Deutschland (2007/2008) 8. Ausgabe. Robert Koch-Institut (ed) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. (ed). Berlin, 2012
9.
Zurück zum Zitat Mitchell DG et al (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112:95–103PubMedCentralPubMedCrossRef Mitchell DG et al (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112:95–103PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Ramirez PT, Jhingran A, Macapinlac HA et al (2011) Laparoscopic extraperitoneal para-aortic lymphadenectomy in locally advanced cervical cancer: a prospective correlation of surgical findings with positron emission tomography/computed tomography findings. Cancer 117:1928–1934PubMedCrossRef Ramirez PT, Jhingran A, Macapinlac HA et al (2011) Laparoscopic extraperitoneal para-aortic lymphadenectomy in locally advanced cervical cancer: a prospective correlation of surgical findings with positron emission tomography/computed tomography findings. Cancer 117:1928–1934PubMedCrossRef
11.
Zurück zum Zitat Leblanc E, Gauthier H, Querleu D et al (2011) Accuracy of 18-fluoro-2-deoxy-D-glucose positron emission tomography in the pretherapeutic detection of occult para-aortic node involvement in patients with a locally advanced cervical carcinoma. Ann Surg Oncol 18:2302–2309PubMedCrossRef Leblanc E, Gauthier H, Querleu D et al (2011) Accuracy of 18-fluoro-2-deoxy-D-glucose positron emission tomography in the pretherapeutic detection of occult para-aortic node involvement in patients with a locally advanced cervical carcinoma. Ann Surg Oncol 18:2302–2309PubMedCrossRef
12.
Zurück zum Zitat Monteil J, Maubon A, Leobon S et al (2011) Lymph node assessment with (18)F-FDG-PET and MRI in uterine cervical cancer. Anticancer Res 31:3865–3871PubMed Monteil J, Maubon A, Leobon S et al (2011) Lymph node assessment with (18)F-FDG-PET and MRI in uterine cervical cancer. Anticancer Res 31:3865–3871PubMed
13.
Zurück zum Zitat Gouy S et al (2012) Nodal-staging surgery for locally advanced cervical cancer in the era of PET. Lancet Oncol 13:e212–e220PubMedCrossRef Gouy S et al (2012) Nodal-staging surgery for locally advanced cervical cancer in the era of PET. Lancet Oncol 13:e212–e220PubMedCrossRef
14.
Zurück zum Zitat Fagotti A et al (2007) Which role for pre-treatment laparoscopic staging? Gynecol Oncol 107(Suppl 1):S101–S105PubMedCrossRef Fagotti A et al (2007) Which role for pre-treatment laparoscopic staging? Gynecol Oncol 107(Suppl 1):S101–S105PubMedCrossRef
15.
Zurück zum Zitat Marnitz S, Köhler C, Roth C et al (2005) Is there a benefit of pre-treatment laparoscopic transperitoneal surgical staging in patients with advanced cervical cancer? Gynecol Oncol 99:536–544PubMedCrossRef Marnitz S, Köhler C, Roth C et al (2005) Is there a benefit of pre-treatment laparoscopic transperitoneal surgical staging in patients with advanced cervical cancer? Gynecol Oncol 99:536–544PubMedCrossRef
16.
Zurück zum Zitat Lai CH, Huang KG, Hong JH et al (2003) Randomized trial of surgical staging (extraperitoneal or laparoscopic) versus clinical staging in locally advanced cervical cancer. Gynecol Oncol 89:160–167PubMedCrossRef Lai CH, Huang KG, Hong JH et al (2003) Randomized trial of surgical staging (extraperitoneal or laparoscopic) versus clinical staging in locally advanced cervical cancer. Gynecol Oncol 89:160–167PubMedCrossRef
17.
Zurück zum Zitat Marnitz S, Köhler C, Burova E et al (2012) Helical tomotherapy with simultaneous integrated boost after laparoscopic staging in patients with cervical cancer: analysis of feasibility and early toxicity. Int J Radiat Oncol Biol Phys 82:e137–e143PubMedCrossRef Marnitz S, Köhler C, Burova E et al (2012) Helical tomotherapy with simultaneous integrated boost after laparoscopic staging in patients with cervical cancer: analysis of feasibility and early toxicity. Int J Radiat Oncol Biol Phys 82:e137–e143PubMedCrossRef
18.
Zurück zum Zitat Marnitz S, Lukarski D, Köhler C et al (2011) Helical tomotherapy versus conventional intensity-modulated radiation therapy for primary chemoradiation in cervical cancer patients: an intraindividual comparison. Int J Radiat Oncol Biol Phys 81:424–430PubMedCrossRef Marnitz S, Lukarski D, Köhler C et al (2011) Helical tomotherapy versus conventional intensity-modulated radiation therapy for primary chemoradiation in cervical cancer patients: an intraindividual comparison. Int J Radiat Oncol Biol Phys 81:424–430PubMedCrossRef
19.
Zurück zum Zitat Koehler C, Gottschalk E, Chiantera V et al (2012) From laparoscopic assisted radical vaginal hysterectomy (LARVH) to vaginal assisted laparoscopic radical hysterectomy (VALRH). BJOG 119:254–262PubMedCrossRef Koehler C, Gottschalk E, Chiantera V et al (2012) From laparoscopic assisted radical vaginal hysterectomy (LARVH) to vaginal assisted laparoscopic radical hysterectomy (VALRH). BJOG 119:254–262PubMedCrossRef
20.
Zurück zum Zitat Cantrell LA, Mandivil A, Gehrig PA, Boggess JF (2010) Survival outcomes for women undergoing type III robotic radical hysterectomy for cervical cancer: a 3-year experience. Gynecol Oncol 117:260–265PubMedCrossRef Cantrell LA, Mandivil A, Gehrig PA, Boggess JF (2010) Survival outcomes for women undergoing type III robotic radical hysterectomy for cervical cancer: a 3-year experience. Gynecol Oncol 117:260–265PubMedCrossRef
21.
Zurück zum Zitat Höckel M, Horn LC, Tetsch E, Einenkel J (2012) Pattern analysis of regional spread and therapeutic lymph node dissection in cervical cancer based on ontogenetic anatomy. Gynecol Oncol 125:168–174PubMedCrossRef Höckel M, Horn LC, Tetsch E, Einenkel J (2012) Pattern analysis of regional spread and therapeutic lymph node dissection in cervical cancer based on ontogenetic anatomy. Gynecol Oncol 125:168–174PubMedCrossRef
22.
Zurück zum Zitat Landoni F, Maneo A, Colombo A et al (1997) Randomised study of radical surgery versus radiotherapy for stage IB-IIa cervical cancer. Lancet 350:535–540PubMedCrossRef Landoni F, Maneo A, Colombo A et al (1997) Randomised study of radical surgery versus radiotherapy for stage IB-IIa cervical cancer. Lancet 350:535–540PubMedCrossRef
23.
Zurück zum Zitat Cengiz M, Dogan A, Ozyigit G et al (2012) Comparison of intracavitary brachytherapy and stereotactic body radiotherapy dose distribution for cervical cancer. Brachytherapy 11:125–129PubMedCrossRef Cengiz M, Dogan A, Ozyigit G et al (2012) Comparison of intracavitary brachytherapy and stereotactic body radiotherapy dose distribution for cervical cancer. Brachytherapy 11:125–129PubMedCrossRef
24.
Zurück zum Zitat Yamashita H, Okuma K, Kawana K et al (2010) Comparison between conventional surgery plus postoperative adjuvant radiotherapy and concurrent chemoradiation for FIGO stage IIB cervical carcinoma: a retrospective study. Am J Clin Oncol 33:583–586PubMedCrossRef Yamashita H, Okuma K, Kawana K et al (2010) Comparison between conventional surgery plus postoperative adjuvant radiotherapy and concurrent chemoradiation for FIGO stage IIB cervical carcinoma: a retrospective study. Am J Clin Oncol 33:583–586PubMedCrossRef
25.
Zurück zum Zitat Schmidt AM, Imesch P, Fink D, Egger H (2012) Indications and long-term clinical outcomes in 282 patients with pelvic exenteration for advanced or recurrent cervical cancer. Gynecol Oncol 125:604–609PubMedCrossRef Schmidt AM, Imesch P, Fink D, Egger H (2012) Indications and long-term clinical outcomes in 282 patients with pelvic exenteration for advanced or recurrent cervical cancer. Gynecol Oncol 125:604–609PubMedCrossRef
26.
Zurück zum Zitat Rose PG, Ali S, Whitney CW et al (2011) Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. Gynecol Oncol 121:542–545PubMedCrossRef Rose PG, Ali S, Whitney CW et al (2011) Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. Gynecol Oncol 121:542–545PubMedCrossRef
27.
Zurück zum Zitat Gong L, Lou JY, Wang P et al (2012) Clinical evaluation of neoadjuvant chemotherapy followed by radical surgery in the management of stage IB2-IIB cervical cancer. Int J Gynaecol Obstet 117:23–26PubMedCrossRef Gong L, Lou JY, Wang P et al (2012) Clinical evaluation of neoadjuvant chemotherapy followed by radical surgery in the management of stage IB2-IIB cervical cancer. Int J Gynaecol Obstet 117:23–26PubMedCrossRef
28.
Zurück zum Zitat Marnitz S, Köhler C, Affonso RJ et al (2012) Validity of laparoscopic staging to avoid adjuvant chemoradiation following radical surgery in patients with early cervical cancer. Oncology 18:346–353CrossRef Marnitz S, Köhler C, Affonso RJ et al (2012) Validity of laparoscopic staging to avoid adjuvant chemoradiation following radical surgery in patients with early cervical cancer. Oncology 18:346–353CrossRef
29.
Zurück zum Zitat Van de Putte G, Lie AK, Vach W et al (2005) Risk grouping in stage IB squamous cell cervical carcinoma. Gynecol Oncol 99:106–112CrossRef Van de Putte G, Lie AK, Vach W et al (2005) Risk grouping in stage IB squamous cell cervical carcinoma. Gynecol Oncol 99:106–112CrossRef
30.
Zurück zum Zitat Delgado G, Bundy B, Zaino R et al (1990) Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 38:352–357PubMedCrossRef Delgado G, Bundy B, Zaino R et al (1990) Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 38:352–357PubMedCrossRef
31.
Zurück zum Zitat Ryu SY, Park SI, Nam BH et al (2011) Is adjuvant chemoradiotherapy overtreatment in cervical cancer patients with intermediate risk factors? Int J Radiat Oncol Biol Phys 79:794–799PubMedCrossRef Ryu SY, Park SI, Nam BH et al (2011) Is adjuvant chemoradiotherapy overtreatment in cervical cancer patients with intermediate risk factors? Int J Radiat Oncol Biol Phys 79:794–799PubMedCrossRef
32.
Zurück zum Zitat Sartori E, Tisi G, Chiudinelli F et al (2007) Early stage cervical cancer: adjuvant treatment in negative lymph node cases. Gynecol Oncol 107:S170–S174PubMedCrossRef Sartori E, Tisi G, Chiudinelli F et al (2007) Early stage cervical cancer: adjuvant treatment in negative lymph node cases. Gynecol Oncol 107:S170–S174PubMedCrossRef
33.
Zurück zum Zitat Morice P, Deyrolle C, Rey A et al (2004) Value of routine follow-up procedures for patients with stage I/IIcervical cancer treated with combined surgery–radiation therapy. Ann Oncol 15:218–223PubMedCrossRef Morice P, Deyrolle C, Rey A et al (2004) Value of routine follow-up procedures for patients with stage I/IIcervical cancer treated with combined surgery–radiation therapy. Ann Oncol 15:218–223PubMedCrossRef
34.
Zurück zum Zitat Bodurka-Bevers D, Morris M, Eifel PJ et al (2000) Posttherapy surveillance of women with cervical cancer: an outcomes analysis. Gynecol Oncol 78:187–193PubMedCrossRef Bodurka-Bevers D, Morris M, Eifel PJ et al (2000) Posttherapy surveillance of women with cervical cancer: an outcomes analysis. Gynecol Oncol 78:187–193PubMedCrossRef
35.
Zurück zum Zitat Chan YM, Ng TY, Ngan YS et al (2002) Monitoring of serum squamous cell carcinoma antigen levels in invasive cervical cancer: is it cost-effective? Gynecol Oncol 84:7–11PubMedCrossRef Chan YM, Ng TY, Ngan YS et al (2002) Monitoring of serum squamous cell carcinoma antigen levels in invasive cervical cancer: is it cost-effective? Gynecol Oncol 84:7–11PubMedCrossRef
36.
Zurück zum Zitat Haie-Meder C, Potter R, Van Limbergen E et al (2005) Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 74:235–245PubMedCrossRef Haie-Meder C, Potter R, Van Limbergen E et al (2005) Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 74:235–245PubMedCrossRef
37.
Zurück zum Zitat Pötter R, Dimopoulos J, Kirisits C et al (2005) Recommendations for image-based intracavitary brachytherapy of cervix cancer: the GYN GEC ESTRO Working Group point of view: in regard to Nag, et al. (Int J Radiat Oncol Biol Phys 2004;60:1160–1172). Int J Radiat Oncol Biol Phys 62:293–295PubMedCrossRef Pötter R, Dimopoulos J, Kirisits C et al (2005) Recommendations for image-based intracavitary brachytherapy of cervix cancer: the GYN GEC ESTRO Working Group point of view: in regard to Nag, et al. (Int J Radiat Oncol Biol Phys 2004;60:1160–1172). Int J Radiat Oncol Biol Phys 62:293–295PubMedCrossRef
38.
Zurück zum Zitat Lindsay R, Paul J, Siddiqui N et al (2012) Survey on the management of early cervical cancer among members of the GCIG. Int J Gynecol Cancer 22(9):1617–1623PubMed Lindsay R, Paul J, Siddiqui N et al (2012) Survey on the management of early cervical cancer among members of the GCIG. Int J Gynecol Cancer 22(9):1617–1623PubMed
39.
Zurück zum Zitat Stangl A et al (2011) Hysterectomy in Germany: a DRG-based nationwide analysis 2005–2006. Dtsch Arztebl Int 108:508–514 Stangl A et al (2011) Hysterectomy in Germany: a DRG-based nationwide analysis 2005–2006. Dtsch Arztebl Int 108:508–514
40.
Zurück zum Zitat Marnitz S, Dowdy S, Lanowska M et al (2009) Exenterations 60 years after first description: results of a survey among US and German Gynecologic Oncology Centers. Int J Gynecol Cancer 19:974–977PubMedCrossRef Marnitz S, Dowdy S, Lanowska M et al (2009) Exenterations 60 years after first description: results of a survey among US and German Gynecologic Oncology Centers. Int J Gynecol Cancer 19:974–977PubMedCrossRef
41.
Zurück zum Zitat Porcorelli S (2006) 26th Annual report on the results of treatment in gynecologic cancer. Int J Gynecol Oncol 95(Suppl 1):S43–S108 Porcorelli S (2006) 26th Annual report on the results of treatment in gynecologic cancer. Int J Gynecol Oncol 95(Suppl 1):S43–S108
42.
Zurück zum Zitat Hertel H, Köhler C, El-Hawary T et al (2002) Laparoscopic staging compared with imaging techniques in the staging of advanced cervical cancer. Gynecol Oncol 87:46–51PubMedCrossRef Hertel H, Köhler C, El-Hawary T et al (2002) Laparoscopic staging compared with imaging techniques in the staging of advanced cervical cancer. Gynecol Oncol 87:46–51PubMedCrossRef
43.
Zurück zum Zitat Mitchell DG, Snyder B, Coakley F et al (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112:95–103PubMedCentralPubMedCrossRef Mitchell DG, Snyder B, Coakley F et al (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112:95–103PubMedCentralPubMedCrossRef
44.
Zurück zum Zitat Bleker SM, Bipat S, Spijkerboer AM et al (2013) The negative predictive value of clinical examination with or without anesthesia versus magnetic resonance imaging for parametrial infiltration in cervical cancer stages IB1 to IIA. Int J Gynecol Cancer 23:193–198PubMedCrossRef Bleker SM, Bipat S, Spijkerboer AM et al (2013) The negative predictive value of clinical examination with or without anesthesia versus magnetic resonance imaging for parametrial infiltration in cervical cancer stages IB1 to IIA. Int J Gynecol Cancer 23:193–198PubMedCrossRef
45.
Zurück zum Zitat Epstein E, Testa A, Gaurilcikas A et al (2013) Early-stage cervical cancer: tumor delineation by magnetic resonance imaging and ultrasound—a European multicenter trial. Gynecol Oncol 128:449–453PubMedCrossRef Epstein E, Testa A, Gaurilcikas A et al (2013) Early-stage cervical cancer: tumor delineation by magnetic resonance imaging and ultrasound—a European multicenter trial. Gynecol Oncol 128:449–453PubMedCrossRef
46.
Zurück zum Zitat Klerkx WM, Veldhuis WB, Spijkerboer AM et al (2012) The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer. Eur J Cancer 48:3414–3421PubMedCrossRef Klerkx WM, Veldhuis WB, Spijkerboer AM et al (2012) The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer. Eur J Cancer 48:3414–3421PubMedCrossRef
47.
Zurück zum Zitat Gold MA, Tian C, Whitney CW et al (2008) Surgical versus radiographic determination of para-aortic lymph node metastases before chemoradiation for locally advanced cervical carcinoma: a Gynecologic Oncology Group Study. Cancer 112:1954–1963PubMedCrossRef Gold MA, Tian C, Whitney CW et al (2008) Surgical versus radiographic determination of para-aortic lymph node metastases before chemoradiation for locally advanced cervical carcinoma: a Gynecologic Oncology Group Study. Cancer 112:1954–1963PubMedCrossRef
48.
Zurück zum Zitat Denschlag D, Gabriel B, Mueller-Lantzsch C et al (2005) Evaluation of patients after extraperitoneal lymph node dissection for cervical cancer. Gynecol Oncol 96:658–664PubMedCrossRef Denschlag D, Gabriel B, Mueller-Lantzsch C et al (2005) Evaluation of patients after extraperitoneal lymph node dissection for cervical cancer. Gynecol Oncol 96:658–664PubMedCrossRef
49.
Zurück zum Zitat Viswanathan AN, Creutzberg CL, Craighead P et al (2012) International brachytherapy practice patterns: a survey of the Gynecologic Cancer Intergroup (GCIG). Int J Radiat Oncol Biol Phys 82:250–255PubMedCentralPubMedCrossRef Viswanathan AN, Creutzberg CL, Craighead P et al (2012) International brachytherapy practice patterns: a survey of the Gynecologic Cancer Intergroup (GCIG). Int J Radiat Oncol Biol Phys 82:250–255PubMedCentralPubMedCrossRef
50.
Zurück zum Zitat Gay HA, Jin JY, Chang AJ, Ten Haken RK (2013) Utility of normal tissue-to-tumor α/β ratio when evaluating isodoses of isoeffective radiation therapy treatment plans. Int J Radiat Oncol Biol Phys 85:e81–e87PubMedCrossRef Gay HA, Jin JY, Chang AJ, Ten Haken RK (2013) Utility of normal tissue-to-tumor α/β ratio when evaluating isodoses of isoeffective radiation therapy treatment plans. Int J Radiat Oncol Biol Phys 85:e81–e87PubMedCrossRef
51.
Zurück zum Zitat Dimopoulos JC, Pötter R, Lang S et al (2009) Dose-effect relationship for local control of cervical cancer by magnetic resonance image-guided brachytherapy. Radiother Oncol 93:311–315PubMedCrossRef Dimopoulos JC, Pötter R, Lang S et al (2009) Dose-effect relationship for local control of cervical cancer by magnetic resonance image-guided brachytherapy. Radiother Oncol 93:311–315PubMedCrossRef
52.
Zurück zum Zitat Schmid MP, Kirisits C, Nesvacil N et al (2011) Local recurrences in cervical cancer patients in the setting of image-guided brachytherapy: a comparison of spatial dose distribution within a matched-pair analysis. Radiother Oncol 100:468–472PubMedCentralPubMedCrossRef Schmid MP, Kirisits C, Nesvacil N et al (2011) Local recurrences in cervical cancer patients in the setting of image-guided brachytherapy: a comparison of spatial dose distribution within a matched-pair analysis. Radiother Oncol 100:468–472PubMedCentralPubMedCrossRef
53.
Zurück zum Zitat Keys HM, Bundy BN, Stehman FB et al (1999) Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340:1154–1161PubMedCrossRef Keys HM, Bundy BN, Stehman FB et al (1999) Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340:1154–1161PubMedCrossRef
54.
Zurück zum Zitat Morris M, Eifel PJ, Lu J et al (1999) Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340:1137–1143PubMedCrossRef Morris M, Eifel PJ, Lu J et al (1999) Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340:1137–1143PubMedCrossRef
55.
Zurück zum Zitat Peters WA 3rd, Liu PY, Barrett RJ 2nd et al (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix. J Clin Oncol 18:1606–1613PubMed Peters WA 3rd, Liu PY, Barrett RJ 2nd et al (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix. J Clin Oncol 18:1606–1613PubMed
56.
Zurück zum Zitat Ryu SY, Lee WM, Kim K et al (2011) Randomized clinical trial of weekly vs. triweekly cisplatin-based chemotherapy concurrent with radiotherapy in the treatment of locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 81:e577–e581PubMedCrossRef Ryu SY, Lee WM, Kim K et al (2011) Randomized clinical trial of weekly vs. triweekly cisplatin-based chemotherapy concurrent with radiotherapy in the treatment of locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 81:e577–e581PubMedCrossRef
57.
Zurück zum Zitat Nagy V, Todor N, Coza O et al (2007) Quality of life and treatment related toxicity in 335 patients with locally advanced cervical carcinoma treated by two chemoradiation regimens. J BUON 12:389–394PubMed Nagy V, Todor N, Coza O et al (2007) Quality of life and treatment related toxicity in 335 patients with locally advanced cervical carcinoma treated by two chemoradiation regimens. J BUON 12:389–394PubMed
58.
Zurück zum Zitat Punushapai U, Yuenyao P, Chumworathayi B et al (2010) Weekly cisplatin 20 mg/m2 in patients with carcinoma of cervix receiving pelvic radiotherapy at Srinagarind Hospital: a randomized controlled trial. Asian Pac J Cancer Prev 11:201–207PubMed Punushapai U, Yuenyao P, Chumworathayi B et al (2010) Weekly cisplatin 20 mg/m2 in patients with carcinoma of cervix receiving pelvic radiotherapy at Srinagarind Hospital: a randomized controlled trial. Asian Pac J Cancer Prev 11:201–207PubMed
59.
Zurück zum Zitat Chumworathayi B, Suprasert P, Charoenkwan K et al (2005) Weekly versus three-weekly cisplatin as an adjunct to radiation therapy in high-risk stage I-IIA cervical cancer after surgery: a randomized comparison of treatment compliance. J Med Assoc Thai 88:1483–1492PubMed Chumworathayi B, Suprasert P, Charoenkwan K et al (2005) Weekly versus three-weekly cisplatin as an adjunct to radiation therapy in high-risk stage I-IIA cervical cancer after surgery: a randomized comparison of treatment compliance. J Med Assoc Thai 88:1483–1492PubMed
60.
Zurück zum Zitat Kim YS, Shin SS, Nam JH et al (2008) Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer. Gynecol Oncol 108:195–200PubMedCrossRef Kim YS, Shin SS, Nam JH et al (2008) Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer. Gynecol Oncol 108:195–200PubMedCrossRef
61.
Zurück zum Zitat Lanciano R, Calkins A, Bundy BN et al (2005) Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a gynecologic oncology group study. J Clin Oncol 23:8289–8295PubMedCrossRef Lanciano R, Calkins A, Bundy BN et al (2005) Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a gynecologic oncology group study. J Clin Oncol 23:8289–8295PubMedCrossRef
62.
Zurück zum Zitat Sehouli J, Runnebaum IB, Fotopoulou C et al (2012) A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study. Ann Oncol 23:2259–2264PubMedCrossRef Sehouli J, Runnebaum IB, Fotopoulou C et al (2012) A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study. Ann Oncol 23:2259–2264PubMedCrossRef
63.
Zurück zum Zitat Cho YH, Kim DJ, Kim JH et al (2009) Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage IB2-IIA bulky cervical cancer. J Gynecol Oncol 20:22–27PubMedCentralPubMedCrossRef Cho YH, Kim DJ, Kim JH et al (2009) Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage IB2-IIA bulky cervical cancer. J Gynecol Oncol 20:22–27PubMedCentralPubMedCrossRef
64.
Zurück zum Zitat Wen H, Wu X, Li Z et al (2012) A prospective randomised controlled study on multiple neoadjuvant treatment for patients with stage IB2-IIA cervical cancer. Int J Gynecol Cancer 22:296–302PubMedCrossRef Wen H, Wu X, Li Z et al (2012) A prospective randomised controlled study on multiple neoadjuvant treatment for patients with stage IB2-IIA cervical cancer. Int J Gynecol Cancer 22:296–302PubMedCrossRef
65.
Zurück zum Zitat Benedetti-Panici P, Greggi S, Colombo A et al (2001) Neoadjuvnat chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicentre randomized study. J Clin Oncol 20:179–188CrossRef Benedetti-Panici P, Greggi S, Colombo A et al (2001) Neoadjuvnat chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicentre randomized study. J Clin Oncol 20:179–188CrossRef
66.
Zurück zum Zitat Yin M, Zhao F, Lou G et al (2011) The long-term efficacy of neoadjuvant chemotherapy followed by radical hysterectomy compared with radical surgery alone or concurrent chemoradiotherapy on locally advanced-stage cervical cancer. Int J Gynecol Cancer 21:92–99PubMed Yin M, Zhao F, Lou G et al (2011) The long-term efficacy of neoadjuvant chemotherapy followed by radical hysterectomy compared with radical surgery alone or concurrent chemoradiotherapy on locally advanced-stage cervical cancer. Int J Gynecol Cancer 21:92–99PubMed
67.
Zurück zum Zitat Lee JY et al (2011) Treatment of stage IB2, IIA bulky cervical cancer: a single-institution experience of neoadjuvant chemotherapy followed by radical hysterectomy and primary radical hysterectomy. Arch Gynecol Obstet 284:477–482PubMedCrossRef Lee JY et al (2011) Treatment of stage IB2, IIA bulky cervical cancer: a single-institution experience of neoadjuvant chemotherapy followed by radical hysterectomy and primary radical hysterectomy. Arch Gynecol Obstet 284:477–482PubMedCrossRef
68.
Zurück zum Zitat Ruy HS et al (2007) Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005). Int J Gynecol Cancer 17:132–136CrossRef Ruy HS et al (2007) Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005). Int J Gynecol Cancer 17:132–136CrossRef
69.
Zurück zum Zitat Eddy GL, Bundy BN, Creasman WT et al (2007) Treatment of (“bulky”) stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a phase III trial of the gynecologic oncology group. Gynecol Oncol 106:362–369PubMedCrossRef Eddy GL, Bundy BN, Creasman WT et al (2007) Treatment of (“bulky”) stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a phase III trial of the gynecologic oncology group. Gynecol Oncol 106:362–369PubMedCrossRef
70.
Zurück zum Zitat Duyn A, Van Eijkeren M, Kenter G et al (2002) Recurrence cervical cancer: detection and prognosis. Acta Obstet Gynecol Scand 81:351–355PubMedCrossRef Duyn A, Van Eijkeren M, Kenter G et al (2002) Recurrence cervical cancer: detection and prognosis. Acta Obstet Gynecol Scand 81:351–355PubMedCrossRef
71.
Zurück zum Zitat Ansink A, Barros Lopes A de, Naik R, Monaghan JM (1996) Recurrent stage IB cervical carcinoma: evaluation of the effectiveness of routine follow-up surveillance. Br J Obstet Gynaecol 103:1156–1158PubMedCrossRef Ansink A, Barros Lopes A de, Naik R, Monaghan JM (1996) Recurrent stage IB cervical carcinoma: evaluation of the effectiveness of routine follow-up surveillance. Br J Obstet Gynaecol 103:1156–1158PubMedCrossRef
72.
Zurück zum Zitat Balleyguir C, Sala E, DaCunha T et al (2011) Staging of uterine cervical cancer with MRI: guidelines of the European Society of urogenital radiology. Eur Radiol 21:1102–1110CrossRef Balleyguir C, Sala E, DaCunha T et al (2011) Staging of uterine cervical cancer with MRI: guidelines of the European Society of urogenital radiology. Eur Radiol 21:1102–1110CrossRef
73.
Zurück zum Zitat Chung HH, Kima JW, Kangb KW et al (2012) Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer. Eur J Radiol 81:e817–e822PubMedCrossRef Chung HH, Kima JW, Kangb KW et al (2012) Predictive role of post-treatment [18F]FDG PET/CT in patients with uterine cervical cancer. Eur J Radiol 81:e817–e822PubMedCrossRef
74.
Zurück zum Zitat Esajas MD, Duk JM, Bruijn HW de et al (2001) Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with early-stage cervical cancer. J Clin Oncol 19:3960–3966PubMed Esajas MD, Duk JM, Bruijn HW de et al (2001) Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with early-stage cervical cancer. J Clin Oncol 19:3960–3966PubMed
75.
Zurück zum Zitat Pras E, Willemse P, Canrinus AA et al (2002) Serum squamous cell carcinoma antigen and Cyfra 21-1 in cervical cancer treatment. Int J Radiat Oncol Biol Phys 52:23–32PubMedCrossRef Pras E, Willemse P, Canrinus AA et al (2002) Serum squamous cell carcinoma antigen and Cyfra 21-1 in cervical cancer treatment. Int J Radiat Oncol Biol Phys 52:23–32PubMedCrossRef
76.
Zurück zum Zitat Rimel BJ, Ferda A, Erwin J et al (2011) Cervicovaginal cytology in the detection of recurrence after cervical cancer treatment. Obstet Gynecol 118:548–553PubMedCrossRef Rimel BJ, Ferda A, Erwin J et al (2011) Cervicovaginal cytology in the detection of recurrence after cervical cancer treatment. Obstet Gynecol 118:548–553PubMedCrossRef
77.
Zurück zum Zitat Elit L, Fyles AW, Devries MC et al (2009) Follow-up for women after treatment for cervical cancer: a systematic review. Gynecol Oncol 114:528–535PubMedCrossRef Elit L, Fyles AW, Devries MC et al (2009) Follow-up for women after treatment for cervical cancer: a systematic review. Gynecol Oncol 114:528–535PubMedCrossRef
78.
Zurück zum Zitat Zanagnolo V, Minig LA, Gadducci A et al (2009) Surveillance procedures for patients for cervical carcinoma. A review of the literature. Int J Gynecol Cancer 19:306–309PubMedCrossRef Zanagnolo V, Minig LA, Gadducci A et al (2009) Surveillance procedures for patients for cervical carcinoma. A review of the literature. Int J Gynecol Cancer 19:306–309PubMedCrossRef
79.
Zurück zum Zitat Nijhuis ER, Zee A van der, Inthout B et al (2006) Gynecologic examination and cervical biopsy after (chemo) radiation for cervical cancer to identify patients eligible for salvage surgery. Int J Radiat Oncol Biol Phys 66:699–705PubMedCrossRef Nijhuis ER, Zee A van der, Inthout B et al (2006) Gynecologic examination and cervical biopsy after (chemo) radiation for cervical cancer to identify patients eligible for salvage surgery. Int J Radiat Oncol Biol Phys 66:699–705PubMedCrossRef
80.
Zurück zum Zitat Classe JM, Rauch P, Rodier JF et al (2006) Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: Morbidity and outcome: Results of a multicenter study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer). Gynecol Oncol 102:523–529PubMedCrossRef Classe JM, Rauch P, Rodier JF et al (2006) Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: Morbidity and outcome: Results of a multicenter study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer). Gynecol Oncol 102:523–529PubMedCrossRef
81.
Zurück zum Zitat Motton S, Houvenaeghel G, Delannes M et al (2010) Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. Int J Gynecol Cancer 20:268–275PubMedCrossRef Motton S, Houvenaeghel G, Delannes M et al (2010) Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. Int J Gynecol Cancer 20:268–275PubMedCrossRef
82.
Zurück zum Zitat Fanfani F, Fagotti A, Ferrandina G et al (2009) Neoadjuvant chemoradiation followed by radical hysterectomy in FIGO Stage IIIB cervical cancer: feasibility, complications, and clinical outcome. Int J Gynecol Cancer 19:1119–1124PubMedCrossRef Fanfani F, Fagotti A, Ferrandina G et al (2009) Neoadjuvant chemoradiation followed by radical hysterectomy in FIGO Stage IIIB cervical cancer: feasibility, complications, and clinical outcome. Int J Gynecol Cancer 19:1119–1124PubMedCrossRef
83.
Zurück zum Zitat Colombo PE, Bertrand MM, Gutowski M et al (2009) Total laparoscopic radical hysterectomy for locally advanced cervical carcinoma (stages IIB, IIA and bulky stages IB) after concurrent chemoradiation therapy: surgical morbidity and oncological results. Gynecol Oncol 114:404–409PubMedCrossRef Colombo PE, Bertrand MM, Gutowski M et al (2009) Total laparoscopic radical hysterectomy for locally advanced cervical carcinoma (stages IIB, IIA and bulky stages IB) after concurrent chemoradiation therapy: surgical morbidity and oncological results. Gynecol Oncol 114:404–409PubMedCrossRef
84.
Zurück zum Zitat Schmid MP, Pötter R, Brader P et al (2013) Feasibility of transrectal ultrasonography for assessment of cervical cancer. Strahlenther Onkol 189:123–128PubMedCrossRef Schmid MP, Pötter R, Brader P et al (2013) Feasibility of transrectal ultrasonography for assessment of cervical cancer. Strahlenther Onkol 189:123–128PubMedCrossRef
85.
Zurück zum Zitat Heinzelmann F, Henke G, Grafenstein M von et al (2012) Weinmann adjuvant radiochemotherapy in patients with locally advanced high-risk cervical cancer. Strahlenther Onkol 188:568–575PubMedCrossRef Heinzelmann F, Henke G, Grafenstein M von et al (2012) Weinmann adjuvant radiochemotherapy in patients with locally advanced high-risk cervical cancer. Strahlenther Onkol 188:568–575PubMedCrossRef
86.
Zurück zum Zitat Vandecasteele K, Makar A, Van den Broecke R et al (2012) Intensity-modulated arc therapy with cisplatin as neo-adjuvant treatment for primary irresectable cervical cancer. Strahlenther Onkol 188:576–581PubMedCrossRef Vandecasteele K, Makar A, Van den Broecke R et al (2012) Intensity-modulated arc therapy with cisplatin as neo-adjuvant treatment for primary irresectable cervical cancer. Strahlenther Onkol 188:576–581PubMedCrossRef
87.
Zurück zum Zitat Alt C, Brocker K, Eichbaum M et al (2011) Hallscheidt Imaging of female pelvic malignancies regarding MRI, CT, and PET/CT. Strahlenther Onkol 187(:705–714PubMedCrossRef Alt C, Brocker K, Eichbaum M et al (2011) Hallscheidt Imaging of female pelvic malignancies regarding MRI, CT, and PET/CT. Strahlenther Onkol 187(:705–714PubMedCrossRef
88.
Zurück zum Zitat Gruen A, Musik T, Köhler C et al (2011) Adjuvant chemoradiation after laparoscopically assisted vaginal radical hysterectomy (LARVH) in patients with cervical cancer. Strahlenther Onkol 187:344–349PubMedCrossRef Gruen A, Musik T, Köhler C et al (2011) Adjuvant chemoradiation after laparoscopically assisted vaginal radical hysterectomy (LARVH) in patients with cervical cancer. Strahlenther Onkol 187:344–349PubMedCrossRef
Metadaten
Titel
Patterns of care in patients with cervical cancer 2012
Results of a survey among German radiotherapy departments and out-patient health care centers
verfasst von
S. Marnitz, M.D.
C. Köhler, M.D.
A. Rauer
A. Schneider, M.D., M.P.H.
V. Budach, M.D.
A. Tsunoda, M.D.
M. Mangler, M.D.
Publikationsdatum
01.01.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Strahlentherapie und Onkologie / Ausgabe 1/2014
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-013-0403-5

Weitere Artikel der Ausgabe 1/2014

Strahlentherapie und Onkologie 1/2014 Zur Ausgabe

Mitteilungen der Fachgesellschaften

Mitteilungen der Fachgesellschaften

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.