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07.12.2016 | Original Article

Stereotactic radiotherapy of vestibular schwannoma

Hearing preservation, vestibular function, and local control following primary and salvage radiotherapy

verfasst von: Florian Putz, MD, Jan Müller, Caterina Wimmer, MD, Nicole Goerig, Stefan Knippen, MD, Heinrich Iro, MD, Philipp Grundtner, Ilker Eyüpoglu, MD, Karl Rössler, MD, Sabine Semrau, MD, Rainer Fietkau, MD, Sebastian Lettmaier, MD

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 3/2017

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Abstract

Objective

The aim of this publication is to present long-term data on functional outcomes and tumor control in a cohort of 107 patients treated with stereotactic radiotherapy (RT) for vestibular schwannoma.

Patients and methods

Included were 107 patients with vestibular schwannoma (primary or recurrent following resection) treated with stereotactic RT (either fractioned or single-dose radiosurgery) between October 2002 and December 2013. Local control and functional outcomes were determined. Analysis of hearing preservation was limited to a subgroup of patients with complete audiometric data collected before treatment and during follow-up. Vestibular function test (FVT) results could be analyzed in a subset of patients and were compared to patient-reported dizziness.

Results

After a mean follow-up of 46.3 months, actuarial local control for the whole cohort was 100% after 2, 97.6% after 5, and 94.1% after 10 years. In patients with primary RT, serviceable hearing was preserved in 72%. Predictors for preservation of serviceable hearing in multivariate analysis were time of follow-up (odds ratio, OR = 0.93 per month; p = 0.021) and pre-RT tumor size (Koos stage I–IIa vs. IIb–IV; OR = 0.15; p = 0.031). Worsening of FVT results was recorded in 17.6% (N = 3). Profound discrepancy of patient-reported dizziness and FVT results was observed after RT. In patients with primary RT, worsening of facial nerve function occurred in 1.7% (N = 1).

Conclusion

Stereotactic RT of vestibular schwannoma provides good functional outcomes and high control rates. Dependence of hearing preservation on time of follow-up and initial tumor stage has to be considered.

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Titel: Stereotactic radiotherapy of vestibular schwannoma
Hearing preservation, vestibular function, and local control following primary and salvage radiotherapy
verfasst von: Florian Putz, MD
Jan Müller
Caterina Wimmer, MD
Nicole Goerig
Stefan Knippen, MD
Heinrich Iro, MD
Philipp Grundtner
Ilker Eyüpoglu, MD
Karl Rössler, MD
Sabine Semrau, MD
Rainer Fietkau, MD
Sebastian Lettmaier, MD
Publikationsdatum: 07.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 3/2017
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-016-1086-5

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Stereotactic radiotherapy of vestibular schwannoma

Hearing preservation, vestibular function, and local control following primary and salvage radiotherapy

Abstract

Objective

Patients and methods

Results

Conclusion

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Patients and methods

Results

Conclusion

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