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14.06.2017 | Review Article

A comparison of swallowing dysfunction after three-dimensional conformal and intensity-modulated radiotherapy

A systematic review by the Italian Head and Neck Radiotherapy Study Group

verfasst von: Stefano Ursino, MD, Elisa D’Angelo, Rosario Mazzola, Anna Merlotti, Riccardo Morganti, Agostino Cristaudo, Fabiola Paiar, Daniela Musio, Daniela Alterio, Almalina Bacigalupo, Elvio Grazioso Russi, Frank Lohr

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 11/2017

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Abstract

Purpose

Dysphagia is one of the most important treatment-related side effects in head and neck cancer (HNC), as it can lead to severe life-threating complications such as aspiration pneumonia and malnutrition. Intensity-modulated radiotherapy (IMRT) could reduce swallowing dysfunction by producing a concave dose distribution and reducing doses to the swallowing-related organs at risk (SWOARs). The aim of this study was to review the current literature in order to compare swallowing outcomes between IMRT and three-dimensional conformal radiotherapy (3DCRT).

Methods

A search was conducted in the PubMed and Embase databases to identify studies on swallowing outcomes, both clinically and/or instrumentally assessed, after 3DCRT and IMRT. Dysphagia-specific quality of life and objective instrumental data are summarized and discussed.

Results

A total of 262 papers were retrieved from the searched databases. An additional 23 papers were retrieved by hand-searching the reference lists. Ultimately, 22 papers were identified which discussed swallowing outcomes after 3DCRT and IMRT for HNC. No outcomes from randomized trials were identified.

Conclusion

Despite several methodological limitations, reports from the current literature seem to suggest better swallowing outcomes with IMRT compared to 3DCRT. Further improvements are likely to result from the increased use of IMRT plans optimized for SWOAR sparing.

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NCCN Clinical Practice Guidelines in Oncology n. d. https://www.nccn.org/professionals/physician_gls/f_guidelines.asp#head-and-neck. Accessed 10.06.2017

Titel: A comparison of swallowing dysfunction after three-dimensional conformal and intensity-modulated radiotherapy
A systematic review by the Italian Head and Neck Radiotherapy Study Group
verfasst von: Stefano Ursino, MD
Elisa D’Angelo
Rosario Mazzola
Anna Merlotti
Riccardo Morganti
Agostino Cristaudo
Fabiola Paiar
Daniela Musio
Daniela Alterio
Almalina Bacigalupo
Elvio Grazioso Russi
Frank Lohr
Publikationsdatum: 14.06.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 11/2017
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-017-1160-7

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

A comparison of swallowing dysfunction after three-dimensional conformal and intensity-modulated radiotherapy

A systematic review by the Italian Head and Neck Radiotherapy Study Group

Abstract

Purpose

Methods

Results

Conclusion

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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