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Erschienen in: European Journal of Trauma and Emergency Surgery 6/2011

01.12.2011 | Original Article

The Glue Grant experience: characterizing the post injury genomic response

verfasst von: A. G. Cuenca, R. V. Maier, J. Cuschieri, E. E. Moore, L. L. Moldawer, R. G. Tompkins, The Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 6/2011

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Abstract

Despite ongoing improvements in resuscitation, care, and outcomes, traumatic injury remains a significant health care and economic burden. The causes are multifactorial, but our approach to the clinical management of these patients remains limited by our current understanding of the pathobiology of the disease. A multicenter, multidisciplinary program known as the “Inflammation and the Host Response to Injury” Large Scale Collaborative Research Program was created by the National Institute of General Medical Sciences (NIGMS, U54 GM062119-10) in 2001 in a 10-year effort to address some of these issues. Its primary goal is to describe the human genomic response to severe trauma and burns, and to examine changes in gene expression in the context of different clinical outcomes. The Program has not only successfully implemented clinical care guidelines for managing the severe trauma patient based on the best available evidence to minimize iatrogenic variability, but it has also examined the genome-wide, immune-inflammatory response in total and isolated blood leukocyte populations. This review will address current milestones as well as future directions for the Program.
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Zurück zum Zitat Cuschieri J, et al. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures (in press) Cuschieri J, et al. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures (in press)
Metadaten
Titel
The Glue Grant experience: characterizing the post injury genomic response
verfasst von
A. G. Cuenca
R. V. Maier
J. Cuschieri
E. E. Moore
L. L. Moldawer
R. G. Tompkins
The Inflammation and Host Response to Injury, Large Scale Collaborative Research Program
Publikationsdatum
01.12.2011
Verlag
Springer-Verlag
Erschienen in
European Journal of Trauma and Emergency Surgery / Ausgabe 6/2011
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-011-0148-8

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