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Die Anaesthesiologie

Erschienen in:

20.06.2016 | Sepsis | Journal Club

Intensivmedizinische Studien aus 2015/2016

verfasst von: C. J. Reuß, M. Bernhard, C. Beynon, S. Hofer, C. Jungk, D. Michalski, Prof. Dr. M. A. Weigand, T. Brenner

Erschienen in: Die Anaesthesiologie | Ausgabe 7/2016

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Die Vielzahl an Studien, die im vergangenen Jahr im intensivmedizinischen Kontext publiziert wurde, ist schier unüberschaubar. Vor diesem Hintergrund bietet die vorliegende Übersichtsarbeit eine Möglichkeit, sich über neue Studienergebnisse strukturiert zu informieren. Nichtsdestotrotz stellt diese Zusammenfassung lediglich eine subjektive Auswahl der nach Ansicht der Autoren relevanten Arbeiten dar. Sie kann und soll somit keinen allumfassenden Überblick über die intensivmedizinische Literatur geben. Die entsprechenden Zusammenfassungen der Studien, Aufführung der Studienakronyme (Tab. 1) und die Einordnung in das bestehende wissenschaftliche Umfeld sollen dennoch wesentlich dazu beitragen, evidenzbasierte Medizin an das Intensivstationsbett zu transportieren.

Tab. 1

2015 erschienene intensivmedizinische Studien und die Bedeutung der Akronyme

Akronym	Bedeutung des Akronyms	Originaltitel der Studie	Ergebnis – kurz zusammengefasst
BLING 2	Beta-Lactam Infusion Group II Study	A Multicenter Randomized Trial of Continuous versus Intermittent beta‑Lactam Infusion in Severe Sepsis	Kontinuierliche Antibiotikainfusion zeigte bei Patienten mit schwerer Sepsis keinen Vorteil gegenüber einer intermittierenden Infusion
STOP-IT	Study to Optimize Peritoneal Infection Therapy	Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection	Nach chirurgischer Herdsanierung zeigte eine Antibiotikagabe bei Patienten mit intraabdomineller Infektion über 8 vs. 4 Tage keinen Vorteil
ProMISe	Protocolised Management in Sepsis	Trial of Early, Goal-Directed Resuscitation for Septic Shock	Protokollbasierte Therapie (EGDT, inkl. SvCO2) zeigte bei Patienten mit septischem Schock gegenüber der Standardtherapie mit Sepsisfrüherkennung, Antibiotika- und Volumengabe keinen Überlebensvorteil
ARISE	Australasian Resuscitation in Sepsis Evaluation	Goal-Directed Resuscitation for Patients with Early Septic Shock
ProCESS	Protocolized Care for Early Septic Shock	A Randomized Trial of Protocol-Based Care for Early Septic Shock
SPLIT	0.9 % Saline vs Plasma-Lyte 148 for Intensive Care Unit Fluid Therapy	Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit	Balancierte Kristalloide im Vergleich zu Kochsalzlösung reduzierten bei Patienten auf der Intensivstation nicht das Risiko für akutes Nierenversagen
TITRe2	Transfusion Indication Threshold Reduction	Liberal or Restrictive Transfusion after Cardiac Surgery	Restriktive Transfusionsregime nach kardiochirurgischen Operationen senkten die Morbidität oder Behandlungskosten nicht
ABLE	Age of Blood Evaluation	Age of Transfused Blood in Critically Ill Adults	Alter der transfundierten Blutkonserven hatten auf die 90-Tages-Letalität bei Patienten auf der Intensivstation keinen Einfluss
FLORALI/REVA	Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients with Acute Lung Injury/ Réseau Européen de Recherche en Ventilation Artificielle	High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure	High-Flow-Sauerstofftherapie senkte nicht die Intubationsrate nach 28 Tagen, aber die 90-Tages-Letalität bei Patienten mit akutem, hypoxischen Atemversagen im Vergleich zu Standardsauerstoffapplikation oder nichtinvasiver Ventilation
PermiT	Permissive Underfeeding versus Target Enteral Feeding in Adult Critically Ill Patients	Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults	Moderate Kalorienreduktion bei kritisch kranken Patienten erhöht nicht die Letalität
HEAT	Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit	Acetaminophen for Fever in Critically Ill Patients with Suspected Infection	Fiebersenkung bei Intensivpatienten hatte keinen Einfluss auf die Intensivtherapiedauer
MR CLEAN	Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands	A randomized trial of intraarterial treatment for acute ischemic stroke	Die mechanische Thrombektomie stellte bei zerebralen Hauptstammverschlüssen in einem definierten Zeitfenster eine effektive ergänzende Therapie zur systemischen Thrombolyse mit signifikanter Verbesserung des Behandlungsergebnisses dar
ESCAPE	Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times	Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
EXTEND-IA	Extending the Time for Thrombolysis in Emergency Neurological Deficits – Intra-Arterial	Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
SWIFT PRIME	Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment	Stent-Retriever Thrombectomy after Intravenous t‑PA vs. t‑PA Alone in Stroke
REVASCAT	Revascularization with Solitaire FR Device versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting within Eight Hours of Symptom Onset	Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke
Eurotherm 3235	European Study of Therapeutic Hypothermia (32–35 °C) for Intracranial Pressure Reduction after Traumatic Brain Injury	Hypothermia for Intracranial Hypertension after Traumatic Brain Injury	Therapeutische Hypothermie verschlechterte bei Patienten mit intrakraniellem Druck über 20 mmHg nach Schädelhirntrauma das neurologische Behandlungsergebnis

…

Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K (2016) Hospital incidence and mortality rates – an analysis of hospital episode (DRG) statistics in Germany from 2007 to 2013. Dtsch Arztebl Int 113:159–166PubMedPubMedCentral

Kaukonen K‑M, Bailey M, Suzuki S, Pilcher D, Bellomo R (2014) Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand. JAMA 311(1308):2000–2012

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, Poll T van der, Vincent JL, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801–810CrossRefPubMed

Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care Trialists (2016) Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med 193:259–272CrossRefPubMed

Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377CrossRefPubMed

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, Rowan KM, Pro MTI (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:1301–1311CrossRefPubMed

Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506CrossRefPubMed

Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693CrossRefPubMed

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644–1655CrossRefPubMed

10.

Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R (2015) Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med 372:1629–1638CrossRefPubMed

11.

Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707–710CrossRefPubMed

12.

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC (2016) Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for sepsis and septic shock (Sepsis-3). JAMA 315:762–774CrossRefPubMed

13.

Le Gall JR, Klar J, Lemeshow S, Saulnier F, Alberti C, Artigas A, Teres D (1996) The logistic organ dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA 276:802–810CrossRefPubMed

14.

Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD, Singer M, Sepsis Definitions Task Force (2016) Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315:775–787CrossRefPubMedPubMedCentral

15.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:580–637CrossRefPubMed

16.

Casserly B, Phillips GS, Schorr C, Dellinger RP, Townsend SR, Osborn TM, Reinhart K, Selvakumar N, Levy MM (2015) Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med 43:567–573CrossRefPubMed

17.

Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC (2010) The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 36:222–231CrossRefPubMedPubMedCentral

18.

Gu WJ, Zhang Z, Bakker J (2015) Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials. Intensive Care Med 41:1862–1863CrossRefPubMed

19.

Haas SA, Lange T, Saugel B, Petzoldt M, Fuhrmann V, Metschke M, Kluge S (2016) Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients. Intensive Care Med 42:202–210CrossRefPubMed

20.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Lipman J (2013) Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. Clin Infect Dis 56:236–244CrossRefPubMed

21.

Falagas ME, Tansarli GS, Ikawa K, Vardakas KZ (2013) Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis. Clin Infect Dis 56:272–282CrossRefPubMed

22.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J, BIIftACTG (2015) A multicenter randomized trial of continuous versus intermittent beta-Lactam infusion in severe sepsis. Am J Respir Crit Care Med 192:1298–1305CrossRefPubMed

23.

Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, Abd Rahman AN, Jamal JA, Wallis SC, Lipman J, Staatz CE, Roberts JA (2016) Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med. doi: 10.1007/s00134-015-4188-0PubMed

24.

Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, Duane TM, Evans HL, Cook CH, O’Neill PJ, Mazuski JE, Askari R, Wilson MA, Napolitano LM, Namias N, Miller PR, Dellinger EP, Watson CM, Coimbra R, Dent DL, Lowry SF, Cocanour CS, West MA, Banton KL, Cheadle WG, Lipsett PA, Guidry CA, Popovsky K (2015) Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med 372:1996–2005CrossRefPubMedPubMedCentral

25.

Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, O’Neill PJ, Chow AW, Dellinger EP, Eachempati SR, Gorbach S, Hilfiker M, May AK, Nathens AB, Sawyer RG, Bartlett JG (2010) Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 50:133–164CrossRefPubMed

26.

Jong E de, Oers JA van, Beishuizen A, Vos P, Vermeijden WJ, Haas LE, Loef BG, Dormans T, Melsen GC van, Kluiters YC, Kemperman H, Elsen MJ van den, Schouten JA, Streefkerk JO, Krabbe HG, Kieft H, Kluge GH, Dam VC van, Pelt J van, Bormans L, Otten MB, Reidinga AC, Endeman H, Twisk JW, Garde EM van de, Smet AM de, Kesecioglu J, Girbes AR, Nijsten MW, Lange DW de (2016) Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis. doi: 10.1016/S1473-3099(16)00053-0

27.

Bernhard M, Brenner T, Brunkhorst FM, Weigand MA (2015) Frühe innerklinische Sepsistherapie. Notf Rettungsmed 18:595–605CrossRef

28.

Myburgh JA, Mythen MG (2013) Resuscitation fluids. N Engl J Med 369:1243–1251CrossRefPubMed

29.

Kumpers P (2015) NaCl 0.9 % for volume substitution: blessing or curse? Internist 56:773–778CrossRefPubMed

30.

Morgan TJ, Venkatesh B, Hall J (2004) Crystalloid strong ion difference determines metabolic acid-base change during acute normovolaemic haemodilution. Intensive Care Med 30:1432–1437CrossRefPubMed

31.

Scheingraber S, Rehm M, Sehmisch C, Finsterer U (1999) Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery. Anesthesiology 90:1265–1270CrossRefPubMed

32.

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R, SPLIT Investigators, ANZICS CTG (2015) Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA 314:1701–1710CrossRefPubMed

33.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup (2004) Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212CrossRefPubMedPubMedCentral

34.

Seymour CW, Rosengart MR (2015) Septic Shock: Advances in Diagnosis and Treatment. JAMA 314:708–717CrossRefPubMed

35.

Labovitz AJ, Noble VE, Bierig M, Goldstein SA, Jones R, Kort S, Porter TR, Spencer KT, Tayal VS, Wei K (2010) Focused cardiac ultrasound in the emergent setting: a consensus statement of the American Society of Echocardiography and American College of Emergency Physicians. J Am Soc Echocardiogr 23:1225–1230CrossRefPubMed

36.

Blum CA, Nigro N, Briel M, Schuetz P, Ullmer E, Suter-Widmer I, Winzeler B, Bingisser R, Elsaesser H, Drozdov D, Arici B, Urwyler SA, Refardt J, Tarr P, Wirz S, Thomann R, Baumgartner C, Duplain H, Burki D, Zimmerli W, Rodondi N, Mueller B, Christ-Crain M (2015) Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 385:1511–1518CrossRefPubMed

37.

Torres A, Sibila O, Ferrer M, Polverino E, Menendez R, Mensa J, Gabarrus A, Sellares J, Restrepo MI, Anzueto A, Niederman MS, Agusti C (2015) Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA 313:677–686CrossRefPubMed

38.

Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y (2015) Corticosteroids for treating sepsis. Cochrane Database Syst Rev 12:CD002243PubMed

39.

Carson JL, Terrin ML, Noveck H, Sanders DW, Chaitman BR, Rhoads GG, Nemo G, Dragert K, Beaupre L, Hildebrand K, Macaulay W, Lewis C, Cook DR, Dobbin G, Zakriya KJ, Apple FS, Horney RA, Magaziner J, FOCUS Investigators (2011) Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 365:2453–2462CrossRefPubMedPubMedCentral

40.

Carson JL, Carless PA, Hebert PC (2012) Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 4:CD002042PubMedPubMedCentral

41.

Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO (2013) Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165:964–971 (e961)CrossRefPubMedPubMedCentral

42.

Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC, TITRe2 Investigators (2015) Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 372:997–1008CrossRefPubMed

43.

Fominskiy E, Putzu A, Monaco F, Scandroglio AM, Karaskov A, Galas FR, Hajjar LA, Zangrillo A, Landoni G (2015) Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials. Br J Anaesth 115:511–519CrossRefPubMed

44.

Tinmouth A, Fergusson D, Yee IC, Hebert PC, ABLE Investigators, Canadian Critical Care Trials Group (2006) Clinical consequences of red cell storage in the critically ill. Transfusion 46:2014–2027CrossRefPubMed

45.

Aubron C, Nichol A, Cooper DJ, Bellomo R (2013) Age of red blood cells and transfusion in critically ill patients. Ann Intensive Care 3:2CrossRefPubMedPubMedCentral

46.

Lacroix J, Hebert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, Watering L van de, Meer NJ van der, Sabri E, Vo D, ABLE Investigators, Canadian Critical Care Trials Group (2015) Age of transfused blood in critically ill adults. N Engl J Med 372:1410–1418CrossRefPubMed

47.

Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307:2526–2533PubMed

48.

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, Haren F van, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A, LUNG SAFE Investigators, ESICM Trials Group (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788–800CrossRefPubMed

49.

Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG (2015) Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 372:747–755CrossRefPubMed

50.

Syndrome TARD, Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342:1301–1308CrossRef

51.

Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R, FLORALI Group, REVA Network (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196CrossRefPubMed

52.

Hernandez G, Vaquero C, Gonzalez P, Subira C, Frutos-Vivar F, Rialp G, Laborda C, Colinas L, Cuena R, Fernandez R (2016) Effect of Postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients:a randomized clinical trial. JAMA 315:1354–1361CrossRefPubMed

53.

Jaber S, Lescot T, Futier E, Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM, Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N, Group NS (2016) Effect of Noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a randomized clinical trial. JAMA 315:1345–1353CrossRefPubMed

54.

Cheung NH, Napolitano LM (2014) Tracheostomy: epidemiology, indications, timing, technique, and outcomes. Respir Care 59:895–915 (discussion 916–899)CrossRefPubMed

55.

Hosokawa K, Nishimura M, Egi M, Vincent JL (2015) Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials. Crit Care 19:424CrossRefPubMedPubMedCentral

56.

Sekiguchi H, Schenck LA, Horie R, Suzuki J, Lee EH, McMenomy BP, Chen TE, Lekah A, Mankad SV, Gajic O (2015) Critical care ultrasonography differentiates ARDS, pulmonary edema, and other causes in the early course of acute hypoxemic respiratory failure. Chest 148:912–918CrossRefPubMed

57.

Weijs PJ, Cynober L, DeLegge M, Kreymann G, Wernerman J, Wolfe RR (2014) Proteins and amino acids are fundamental to optimal nutrition support in critically ill patients. Crit Care 18:591CrossRefPubMedPubMedCentral

58.

Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, Mehta S, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L (2015) Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med 372:2398–2408CrossRefPubMed

59.

Arabi YM, Tamim HM, Dhar GS, Al-Dawood A, Al-Sultan M, Sakkijha MH, Kahoul SH, Brits R (2011) Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am J Clin Nutr 93:569–577CrossRefPubMed

60.

Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, Haren F van, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherall M, Webb S, Beasley R, HEAT Investigators, Australian, New Zealand Intensive Care Society Clinical Trials Group (2015) Acetaminophen for fever in critically ill patients with suspected infection. N Engl J Med 373:2215–2224CrossRefPubMed

61.

Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, Kummer R von, Wahlgren N, Toni D, ECASS Investigators (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317–1329CrossRefPubMed

62.

Friedrich B, Gawlitza M, Schob S, Hobohm C, Raviolo M, Hoffmann KT, Lobsien D (2015) Distance to thrombus in acute middle cerebral artery occlusion: a predictor of outcome after intravenous thrombolysis for acute ischemic stroke. Stroke 46:692–696CrossRefPubMed

63.

Riedel CH, Zimmermann P, Jensen-Kondering U, Stingele R, Deuschl G, Jansen O (2011) The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length. Stroke 42:1775–1777CrossRefPubMed

64.

Badhiwala JH, Nassiri F, Alhazzani W, Selim MH, Farrokhyar F, Spears J, Kulkarni AV, Singh S, Alqahtani A, Rochwerg B, Alshahrani M, Murty NK, Alhazzani A, Yarascavitch B, Reddy K, Zaidat OO, Almenawer SA (2015) Endovascular thrombectomy for acute ischemic stroke: a meta-analysis. JAMA 314:1832–1843CrossRefPubMed

65.

Campbell BC, Donnan GA, Lees KR, Hacke W, Khatri P, Hill MD, Goyal M, Mitchell PJ, Saver JL, Diener HC, Davis SM (2015) Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke. Lancet Neurol 14:846–854CrossRefPubMed

66.

Khatri P, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B, Ciccone A, Davalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD, Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SC, Mitchell P, Mocco J, Muir K, Nogueira RG, Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White PM, Zaidat OO, Liebeskind DS, Fulton R, Lees KR, VISTA-Endovascular Collaboration (2015) State of acute endovascular therapy: report from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke 46:1727–1734CrossRefPubMed

67.

Berkhemer OA, Fransen PS, Beumer D, Berg LA van den, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, Walderveen MA van, Staals J, Hofmeijer J, Oostayen JA van, Lycklama a Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, Bruijn SF de, Dijk LC van, Kappelle LJ, Lo RH, Dijk EJ van, Vries J de, Kort PL de, Rooij WJ van, Berg JS van den, Hasselt BA van, Aerden LA, Dallinga RJ, Visser MC, Bot JC, Vroomen PC, Eshghi O, Schreuder TH, Heijboer RJ, Keizer K, Tielbeek AV, Hertog HM den, Gerrits DG, Berg-Vos RM van den, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SF, Beenen LF, Berg R van den, Koudstaal PJ, Zwam WH van, Roos YB, Lugt A van der, Oostenbrugge RJ van, Majoie CB, Dippel DW, MR CLEAN Investigators (2015) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372:11–20CrossRefPubMed

68.

Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD, ESCAPE Trial Investigators (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372:1019–1030CrossRefPubMed

69.

Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, Villiers L de, Ma H, Desmond PM, Donnan GA, Davis SM, EXTEND-IA Investigators (2015) Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 372:1009–1018CrossRefPubMed

70.

Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, Kummer R von, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC Jr., Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ, Stroke Imaging Research (STIR), Virtual International Stroke Trials Archive (VISTA-) Imaging Investigators (2013) Acute Stroke Imaging Research Roadmap II. Stroke 44(9):2628–2639. doi:10.1161/STROKEAHA.113.002015CrossRefPubMedPubMedCentral

71.

Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahan R, SWIFT PRIME Investigators (2015) Stent-retriever thrombectomy after intravenous t‑PA vs. t‑PA alone in stroke. N Engl J Med 372:2285–2295CrossRefPubMed

72.

Jovin TG, Chamorro A, Cobo E, Miquel MA de, Molina CA, Rovira A, San Roman L, Serena J, Abilleira S, Ribo M, Millan M, Urra X, Cardona P, Lopez-Cancio E, Tomasello A, Castano C, Blasco J, Aja L, Dorado L, Quesada H, Rubiera M, Hernandez-Perez M, Goyal M, Demchuk AM, Kummer R von, Gallofre M, Davalos A, REVASCAT Trial Investigators (2015) Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 372:2296–2306CrossRefPubMed

73.

Dhakal LP, Diaz-Gomez JL, Freeman WD (2015) Role of anesthesia for endovascular treatment of ischemic stroke: do we need neurophysiological monitoring? Stroke 46:1748–1754CrossRefPubMed

74.

Schonenberger S, Bosel J (2015) Peri-interventional management of acute endovascular stroke treatment. Nervenarzt 86:1217–1225CrossRefPubMed

75.

Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP (2014) Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice. J Neurotrauma 31:1417–1430CrossRefPubMedPubMedCentral

76.

Crossley S, Reid J, McLatchie R, Hayton J, Clark C, MacDougall M, Andrews PJ (2014) A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury. Crit Care 18:R75CrossRefPubMedPubMedCentral

77.

Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK, Murray GD, Eurotherm3235 Trial Collaborators (2015) Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med 373:2403–2412CrossRefPubMed

78.

Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger JE, Surgical Management of Traumatic Brain Injury Author Group (2006) Surgical management of acute subdural hematomas. Neurosurgery 58:S16–S24 (discussion Si–iv)PubMed

79.

Mendelow AD, Gregson BA, Rowan EN, Francis R, McColl E, McNamee P, Chambers IR, Unterberg A, Boyers D, Mitchell PM, STITCH(Trauma) Investigators (2015) Early surgery versus initial conservative treatment in patients with traumatic intracerebral hemorrhage (STITCH[trauma]): the first randomized trial. J Neurotrauma 32:1312–1323CrossRefPubMedPubMedCentral

80.

Kuramatsu JB, Gerner ST, Schellinger PD, Glahn J, Endres M, Sobesky J, Flechsenhar J, Neugebauer H, Juttler E, Grau A, Palm F, Rother J, Michels P, Hamann GF, Huwel J, Hagemann G, Barber B, Terborg C, Trostdorf F, Bazner H, Roth A, Wohrle J, Keller M, Schwarz M, Reimann G, Volkmann J, Mullges W, Kraft P, Classen J, Hobohm C, Horn M, Milewski A, Reichmann H, Schneider H, Schimmel E, Fink GR, Dohmen C, Stetefeld H, Witte O, Gunther A, Neumann-Haefelin T, Racs AE, Nueckel M, Erbguth F, Kloska SP, Dorfler A, Kohrmann M, Schwab S, Huttner HB (2015) Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage. JAMA 313:824–836CrossRefPubMed

81.

Liu B, Liu S, Yin A, Siddiqi J (2015) Risks and benefits of stress ulcer prophylaxis in adult neurocritical care patients: a systematic review and meta-analysis of randomized controlled trials. Crit Care 19:409CrossRefPubMedPubMedCentral

82.

Larsen CC, Astrup J (2013) Rebleeding after aneurysmal subarachnoid hemorrhage: a literature review. World Neurosurg 79:307–312CrossRefPubMed

83.

Steiner T, Juvela S, Unterberg A, Jung C, Forsting M, Rinkel G, European Stroke Organization (2013) European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis 35:93–112CrossRefPubMed

84.

Donkelaar CE van, Bakker NA, Veeger NJ, Uyttenboogaart M, Metzemaekers JD, Luijckx GJ, Groen RJ, Dijk JM van (2015) Predictive factors for rebleeding after aneurysmal subarachnoid hemorrhage: rebleeding Aneurysmal Subarachnoid Hemorrhage Study. Stroke 46:2100–2106CrossRefPubMed

85.

Dellinger RP et al (2012) Crit Care Med 41:580–637CrossRef

86.

The ARDS Definitions Task Force (2012) JAMA 307:2526–2533

Titel: Intensivmedizinische Studien aus 2015/2016
verfasst von: C. J. Reuß
M. Bernhard
C. Beynon
S. Hofer
C. Jungk
D. Michalski
Prof. Dr. M. A. Weigand
T. Brenner
Publikationsdatum: 20.06.2016
Verlag: Springer Berlin Heidelberg
Schlagwörter: Sepsis
Sepsis
Septischer Schock
Erschienen in: Die Anaesthesiologie / Ausgabe 7/2016
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-016-0188-x

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