Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 1/2016

01.01.2016 | Originalien und Übersichten

Antibiotika-resistente Erreger in Deutschland

Die Rolle von nicht nosokomialen Ansteckungsquellen

verfasst von: Evgeny A. Idelevich, Christian Lanckohr, Dagmar Horn, Lothar H. Wieler, Karsten Becker, Priv.-Doz. Dr. med Robin Köck

Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Ausgabe 1/2016

Einloggen, um Zugang zu erhalten

Zusammenfassung

Hintergrund

Die Frage, ob die zunehmende Verbreitung von Erregern mit Antibiotika-Multiresistenzen (MRE) beim Menschen durch Übertragungen von Tieren erklärbar ist, wird öffentlich diskutiert.

Ziel der Arbeit

Diese Übersichtsarbeit trägt Daten zum Vorkommen von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase (ESBL) bildenden Enterobakterien bei Mensch und Tier zusammen und beschreibt die Erkenntnisse zur zoonotischen Transmission.

Material und Methoden

Es wurde eine Literaturrecherche durchgeführt. Relevante Literatur wurde durch Screening von Überschriften und Abstracts identifiziert und ergänzt durch Publikationen von Infektionsschutzbehörden bzw. die dort zitierten Originalarbeiten.

Ergebnisse

Es zeigte sich eine Vielzahl nosokomialer Verbreitungswege von MRE sowie eine zunehmende Relevanz von außerhalb des Gesundheitswesens gelegenen Infektionsquellen.

Diskussion

Für eine effektive Prävention von MRE ist ein interdisziplinärer Ansatz notwendig, der sowohl die Grenzen medizinischer und pharmazeutischer Fachgebiete als auch die Grenzen zwischen Human- und Veterinärmedizin überschreitet.
Literatur
1.
Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2012) Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 55:1311–1354CrossRef
2.
Kaase M (2014) Bericht des Nationalen Referenzzentrums für gramnegative Krankenhauserreger (1. Januar 2013 bis 31. Dezember 2013). EpiBull 43:421–425
3.
Wellington EM, Boxall AB, Cross P et al (2013) The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. Lancet Infect Dis 13:155–165PubMedCrossRef
4.
Rodriguez-Rojas A, Rodriguez-Beltran J, Couce A, Blazquez J (2013) Antibiotics and antibiotic resistance: a bitter fight against evolution. Int J Med Microbiol 303:293–297PubMedCrossRef
5.
Mehraj J, Akmatov MK, Strompl J et al (2014) Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany. PLoS One 9:e107937PubMedPubMedCentralCrossRef
6.
Herrmann M, Petit C, Dawson A et al (2013) Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. PLoS One 8:e73876PubMedPubMedCentralCrossRef
7.
Köck R, Mellmann A, Schaumburg F, Friedrich AW, Kipp F, Becker K (2011) The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Germany. Dtsch Arztebl Int 108:761–767PubMedPubMedCentral
8.
Wegner C, Hübner NO, Gleich S, Thalmaier U, Krüger CM, Kramer A (2013) One-day point prevalence of emerging bacterial pathogens in a nationwide sample of 62 German hospitals in 2012 and comparison with the results of the one-day point prevalence of 2010. GMS Hyg Infect Control 8(1):Doc12
9.
Gruber I, Heudorf U, Werner G et al (2013) Multidrug-resistant bacteria in geriatric clinics, nursing homes, and ambulant care–prevalence and risk factors. Int J Med Microbiol 303:405–409PubMedCrossRef
10.
Heudorf U, Gustav C, Mischler D, Schulze J (2014) Healthcare associated infections (HAI), antibiotic use and prevalence of multidrug-resistant bacteria (MDRO) in residents of long-term care facilities: the Frankfurt HALT plus MDRO project 2012. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 57:414–422CrossRef
11.
Valenza G, Nickel S, Pfeifer Y et al (2014) Extended-spectrum-beta-lactamase-producing Escherichia coli as intestinal colonizers in the German community. Antimicrob Agents Chemother 58:1228–1230PubMedPubMedCentralCrossRef
12.
Belmar Campos C, Fenner I, Wiese N et al (2014) Prevalence and genotypes of extended spectrum beta-lactamases in Enterobacteriaceae isolated from human stool and chicken meat in Hamburg, Germany. Int J Med Microbiol 304:678–684PubMedCrossRef
13.
Meyer E, Gastmeier P, Kola A, Schwab F (2012) Pet animals and foreign travel are risk factors for colonisation with extended-spectrum beta-lactamase-producing Escherichia coli. Infection 40:685–687PubMedCrossRef
14.
Lübbert C, Straube L, Stein C et al (2015) Colonization with extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacteriaceae in international travelers returning to Germany. Int J Med Microbiol 305:148–156PubMedCrossRef
15.
Ehrhard I, Karaalp AK, Hackel T et al (2014) Prevalence of carbapenemase-producing bacteria in hospitals in Saxony, Germany. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 57:406–413CrossRef
16.
Vehreschild MJ, Hamprecht A, Peterson L et al (2014) A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies. J Antimicrob Chemother 69:3387–3392PubMedCrossRef
17.
Arvand M, Moser V, Pfeifer Y (2013) Prevalence of extended-spectrum-beta-lactamase-producing Escherichia coli and spread of the epidemic clonal lineage ST131 in nursing homes in Hesse, Germany. J Antimicrob Chemother 68:2686–2688PubMedCrossRef
18.
Maechler F, Pena Diaz LA, Schröder C, Geffers C, Behnke M, Gastmeier P (2015) Prevalence of carbapenem-resistant organisms and other Gram-negative MDRO in German ICUs: first results from the national nosocomial infection surveillance system (KISS). Infection 43:163–168PubMedCrossRef
19.
Hering J, Hille K, Fromke C et al (2014) Prevalence and potential risk factors for the occurrence of cefotaxime resistant Escherichia coli in German fattening pig farms – A cross-sectional study. Prev Vet Med 116:129–137PubMedCrossRef
20.
Friese A, Schulz J, Laube H, von Salviati C, Hartung J, Roesler U (2013) Faecal occurrence and emissions of livestock-associated methicillin-resistant Staphylococcus aureus (laMRSA) and ESbl/AmpC-producing E. coli from animal farms in Germany. Berl Munch Tierarztl Wochenschr 126:175–180PubMed
21.
Laube H, Friese A, von Salviati C et al (2013) Longitudinal monitoring of extended-spectrum-beta-lactamase/AmpC-producing Escherichia coli at German broiler chicken fattening farms. Appl Environ Microbiol 79:4815–4820PubMedPubMedCentralCrossRef
22.
Schmid A, Hormansdorfer S, Messelhausser U, Käsbohrer A, Sauter-Louis C, Mansfeld R (2013) Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli on bavarian dairy and beef cattle farms. Appl Environ Microbiol 79:3027–3032PubMedPubMedCentralCrossRef
23.
Hille K, Fischer J, Falgenhauer L et al (2014) On the occurence of Extended-spectrum- and AmpC-betalactamase- producing Escherichia coli in livestock: results of selected European studies. Berl Munch Tierarztl Wochenschr 127:403–411PubMed
24.
Köck R, Harlizius J, Bressan N et al (2009) Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitals. Eur J Clin Microbiol Infect Dis 28:1375–1382PubMedPubMedCentralCrossRef
25.
Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) (2010) Berichte zur Lebensmittelsicherheit 2009: Zoonosen-Monitoring. Springer, Basel
26.
Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) (2012) Berichte zur Lebensmittelsicherheit 2010: Zoonosen-Monitoring. Springer, Basel
27.
Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) (2013) Berichte zur Lebensmittelsicherheit 2011: Zoonosen-Monitoring. Springer, Basel
28.
Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) (2014) Berichte zur Lebensmittelsicherheit 2012: Zoonosen-Monitoring. Springer, Basel
29.
Kola A, Kohler C, Pfeifer Y et al (2012) High prevalence of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in organic and conventional retail chicken meat, Germany. J Antimicrob Chemother 67:2631–2634PubMedCrossRef
30.
Sharp H, Valentin L, Fischer J, Guerra B, Appel B, Käsbohrer A (2014) Estimation of the transfer of ESBL-producing Escherichia coli to humans in Germany. Berl Munch Tierarztl Wochenschr 127:464–477PubMed
31.
Beneke B, Klees S, Stuhrenberg B, Fetsch A, Kraushaar B, Tenhagen BA (2011) Prevalence of methicillin-resistant Staphylococcus aureus in a fresh meat pork production chain. J Food Prot 74:126–129PubMedCrossRef
32.
Feßler AT, Kadlec K, Hassel M et al (2011) Characterization of methicillin-resistant Staphylococcus aureus isolates from food and food products of poultry origin in Germany. Appl Environ Microbiol 77:7151–7157PubMedPubMedCentralCrossRef
33.
Reuland EA, Al Naiemi N, Raadsen SA, Savelkoul PH, Kluytmans JA, Vandenbroucke-Grauls CM (2014) Prevalence of ESBL-producing Enterobacteriaceae in raw vegetables. Eur J Clin Microbiol Infect Dis 33:1843–1846PubMedPubMedCentralCrossRef
34.
von Salviati C, Laube H, Guerra B, Roesler U, Friese A (2015) Emission of ESBL/AmpC-producing Escherichia coli from pig fattening farms to surrounding areas. Vet Microbiol 175:77–84CrossRef
35.
Schulz J, Friese A, Klees S et al (2012) LA-MRSA contamination of air and soil surfaces in the vicinity of pig barns: a longitudinal study. Appl Environ Microbiol 78:5666–5671PubMedPubMedCentralCrossRef
36.
Friese A, Schulz J, Hoehle L et al (2012) Occurrence of MRSA in air and housing environment of pig barns. Vet Microbiol 158:129–135PubMedCrossRef
37.
Laube H, Friese A, von Salviati C, Guerra B, Rösler U (2014) Transmission of ESBL/AmpC-producing Escherichia coli from broiler chicken farms to surrounding areas. Vet Microbiol 172:519–527PubMedCrossRef
38.
Friese A, Schulz J, Zimmermann K et al (2013) Occurrence of livestock-associated methicillin-resistant Staphylococcus aureus in turkey and broiler barns and contamination of air and soil surfaces in their vicinity. Appl Environ Microbiol 79:2759–2766PubMedPubMedCentralCrossRef
39.
Ewers C, Bethe A, Stamm I et al (2014) CTX-M-15-D-ST648 Escherichia coli from companion animals and horses: another pandemic clone combining multiresistance and extraintestinal virulence? J Antimicrob Chemother 69:1224–1230PubMedCrossRef
40.
Ewers C, Grobbel M, Bethe A, Wieler LH, Guenther S (2011) Extended-spectrum beta-lactamases-producing gram-negative bacteria in companion animals: action is clearly warranted! Berl Munch Tierarztl Wochenschr 124:94–101PubMed
41.
42.
Seguin JC, Walker RD, Caron JP et al (1999) Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human-to-animal transmission. J Clin Microbiol 37:1459–1463PubMedPubMedCentral
43.
Dargatz DA, Traub-Dargatz JL (2004) Multidrug-resistant Salmonella and nosocomial infections. Vet Clin North Am Equine Pract 20:587–600PubMedCrossRef
44.
Boerlin P, Eugster S, Gaschen F, Straub R, Schawalder P (2001) Transmission of opportunistic pathogens in a veterinary teaching hospital. Vet Microbiol 82:347–359PubMedCrossRef
45.
Stolle I, Prenger-Berninghoff E, Stamm I et al (2013) Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs. J Antimicrob Chemother 68:2802–2808PubMedCrossRef
46.
Vincze S, Stamm I, Kopp PA et al (2014) Alarming proportions of methicillin-resistant Staphylococcus aureus (MRSA) in wound samples from companion animals, Germany 2010–2012. PLoS One 9:e85656PubMedPubMedCentralCrossRef
47.
Maddox TW, Clegg PD, Diggle PJ et al (2012) Cross-sectional study of antimicrobial-resistant bacteria in horses. Part 1: prevalence of antimicrobial-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus. Equine Vet J 44:289–296PubMedCrossRef
48.
Guenther S, Aschenbrenner K, Stamm I et al (2012) Comparable high rates of extended-spectrum-beta-lactamase-producing Escherichia coli in birds of prey from Germany and Mongolia. PLoS One 7:e53039PubMedPubMedCentralCrossRef
49.
Guenther S, Bethe A, Fruth A et al (2012) Frequent combination of antimicrobial multiresistance and extraintestinal pathogenicity in Escherichia coli isolates from urban rats (Rattus norvegicus) in Berlin, Germany. PLoS One 7:e50331PubMedPubMedCentralCrossRef
50.
Guenther S, Ewers C, Wieler LH (2011) Extended-spectrum beta-lactamases producing E. coli in wildlife, yet another form of environmental pollution? Front Microbiol 2:246PubMedPubMedCentralCrossRef
51.
52.
Schink AK, Kadlec K, Kaspar H, Mankertz J, Schwarz S (2013) Analysis of extended-spectrum-beta-lactamase-producing Escherichia coli isolates collected in the GERM-Vet monitoring programme. J Antimicrob Chemother 68:1741–1749PubMedCrossRef
53.
Köck R, Ballhausen B, Bischoff M et al (2014) The burden of zoonotic MRSA colonization and infection in Germany. Berl Munch Tierarztl Wochenschr 127:384–398PubMed
54.
Layer F, Cuny C, Strommenger B, Werner G, Witte W (2012) [Current data and trends on methicillin-resistant Staphylococcus aureus (MRSA)]. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 55:1377–1386CrossRef
55.
Schaumburg F, Köck R, Mellmann A et al (2012) Population dynamics among methicillin resistant Staphylococcus aureus in Germany during a 6-year period. J Clin Microbiol 50:3186–3192PubMedPubMedCentralCrossRef
56.
Köck R, Schaumburg F, Mellmann A et al (2013) Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) as causes of human infection and colonization in Germany. PLoS One 8:e55040PubMedPubMedCentralCrossRef
57.
Becker K, Ballhausen B, Köck R, Kriegeskorte A (2014) Methicillin resistance in Staphylococcus isolates: the „mec alphabet“ with specific consideration of mecC, a mec homolog associated with zoonotic S. aureus lineages. Int J Med Microbiol 304:794–804PubMedCrossRef
58.
59.
Cuny C, Layer F, Strommenger B, Witte W (2011) Rare occurrence of methicillin-resistant Staphylococcus aureus CC130 with a novel mecA homologue in humans in Germany. PLoS One 6:e24360PubMedPubMedCentralCrossRef
60.
61.
Ewers C, Bethe A, Semmler T, Guenther S, Wieler LH (2012) Extended-spectrum beta-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective. Clin Microbiol Infect 18:646–655PubMedCrossRef
62.
Richter A, Sting R, Popp C et al (2012) Prevalence of types of methicillin-resistant Staphylococcus aureus in turkey flocks and personnel attending the animals. Epidemiol Infect 140 2223–2232PubMedPubMedCentralCrossRef
63.
Dahms C, Hübner NO, Cuny C, Kramer A (2014) Occurrence of methicillin-resistant Staphylococcus aureus in farm workers and the livestock environment in Mecklenburg-Western Pomerania, Germany. Acta Vet Scand 56:53PubMedPubMedCentralCrossRef
64.
Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2014) Empfehlungen zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus-aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 57:696–732
65.
Dierikx C, van der Goot J, Fabri T, van Essen-Zandbergen A, Smith H, Mevius D (2013) Extended-spectrum-beta-lactamase- and AmpC-beta-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers. J Antimicrob Chemother 68:60–67PubMedCrossRef
66.
Köck R, Loth B, Koksal M, Schulte-Wulwer J, Harlizius J, Friedrich AW (2012) Persistence of nasal colonization with livestock-associated methicillin-resistant Staphylococcus aureus in pig farmers after holidays from pig exposure. Appl Environ Microbiol 78:4046–4047PubMedPubMedCentralCrossRef
67.
Deiters C, Günnewig V, Friedrich AW, Mellmann A, Köck R (2015) Are cases of Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 among humans still livestock-associated? Int J Med Microbiol 305:110–113PubMedCrossRef
68.
Feingold BJ, Silbergeld EK, Curriero FC, van Cleef BA, Heck ME, Kluytmans JA (2012) Livestock density as risk factor for livestock-associated methicillin-resistant Staphylococcus aureus, the Netherlands. Emerg Infect Dis 18:1841–1849PubMedPubMedCentralCrossRef
69.
van Rijen MM, Bosch T, Verkade EJ, Schouls L, Kluytmans JA, Group CAMS (2014) Livestock-associated MRSA carriage in patients without direct contact with livestock. PLoS One 9:e100294PubMedPubMedCentralCrossRef
70.
Bisdorff B, Scholholter JL, Claussen K, Pulz M, Nowak D, Radon K (2012) MRSA-ST398 in livestock farmers and neighbouring residents in a rural area in Germany. Epidemiol Infect 140:1800–1808PubMedCrossRef
71.
Dahms C, Hübner NO, Wilke F, Kramer A (2014) Mini-review: Epidemiology and zoonotic potential of multiresistant bacteria and Clostridium difficile in livestock and food. GMS Hyg Infect Control 9:Doc21PubMedPubMedCentral
72.
Wendlandt S, Schwarz S, Silley P (2013) Methicillin-resistant Staphylococcus aureus: a food-borne pathogen? Annu Rev Food Sci Technol 4:117–139PubMedCrossRef
73.
74.
Vincze S, Brandenburg AG, Espelage W et al (2014) Risk factors for MRSA infection in companion animals: results from a case-control study within Germany. Int J Med Microbiol 304:787–793PubMedCrossRef
75.
Nienhoff U, Kadlec K, Chaberny IF et al (2009) Transmission of methicillin-resistant Staphylococcus aureus strains between humans and dogs: two case reports. J Antimicrob Chemother 64:660–662PubMedCrossRef
76.
Abdelbary MM, Wittenberg A, Cuny C et al (2014) Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses. PLoS One 9:e88083PubMedPubMedCentralCrossRef
77.
Schmiedel J, Falgenhauer L, Domann E et al (2014) Multiresistant extended-spectrum beta-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany. BMC Microbiol 14:187PubMedPubMedCentralCrossRef
78.
Leistner R, Meyer E, Gastmeier P et al (2013) Risk factors associated with the community-acquired colonization of extended-spectrum beta-lactamase (ESBL) positive Escherichia Coli. An exploratory case-control study. PLoS One 8:e74323PubMedPubMedCentralCrossRef
79.
Königer D, Gastmeier P, Kola A, Schwab F, Meyer E (2014) Vegetarians are not less colonized with extended-spectrum-beta-lactamase-producing bacteria than meat eaters. J Antimicrob Chemother 69:281–282PubMedCrossRef
80.
Kluytmans JA, Overdevest IT, Willemsen I et al (2013) Extended-spectrum beta-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors. Clin Infect Dis 56:478–487PubMedCrossRef
81.
Valentin L, Sharp H, Hille K et al (2014) Subgrouping of ESBL-producing Escherichia coli from animal and human sources: an approach to quantify the distribution of ESBL types between different reservoirs. Int J Med Microbiol 304:805–816PubMedCrossRef
82.
83.
von Wintersdorff CJ, Penders J, Stobberingh EE et al (2014) High rates of antimicrobial drug resistance gene acquisition after international travel, The Netherlands. Emerg Infect Dis 20:649–657CrossRef
84.
Jorgensen SB, Samuelsen O, Sundsfjord A et al (2014) High prevalence of faecal carriage of ESBL-producing Enterobacteriaceae in Norwegian patients with gastroenteritis. Scand J Infect Dis 46:462–465PubMedCrossRef
85.
Tham J, Walder M, Melander E, Odenholt I (2012) Duration of colonization with extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellersʼ diarrhoea. Scand J Infect Dis 44:573–577PubMedCrossRef
86.
Mutters NT, Mersch-Sundermann V, Mutters R, Brandt C, Schneider-Brachert W, Frank U (2013) Control of the spread of vancomycin-resistant Enterococci in hospitals: epidemiology and clinical relevance. Dtsch Arztebl Int 110:725–731PubMedPubMedCentral
87.
Verkade E, van Benthem B, den Bergh MK et al (2013) Dynamics and determinants of Staphylococcus aureus carriage in livestock veterinarians: a prospective cohort study. Clin Infect Dis 57:e11–e17CrossRef
88.
Nathaus R, Schulz J, Hartung J et al (2011) [Investigations into the use of respiratory masks for reducing the MRSA-exposure of veterinarians visiting regularly pig herds – first experiences]. Berl Munch Tierarztl Wochenschr 124:128–135PubMed
89.
Ballhausen B, Jung P, Kriegeskorte A et al (2014) LA-MRSA CC398 differ from classical community acquired-MRSA and hospital acquired-MRSA lineages: functional analysis of infection and colonization processes. Int J Med Microbiol 304:777–786PubMedCrossRef
90.
Köck R, Becker K, Cookson B et al (2014) Systematic literature analysis and review of targeted preventive measures to limit healthcare-associated infections by meticillin-resistant Staphylococcus aureus. Euro Surveill 19:pii: 20860
91.
Jurke A, Köck R, Becker K et al (2013) Reduction of the nosocomial meticillin-resistant Staphylococcus aureus incidence density by a region-wide search and follow-strategy in forty German hospitals of the EUREGIO, 2009 to 2011. Euro Surveill 18:pii=20579
92.
Blouin DD (2008) All in the family? understanding the meaning of dogs and cats in the Lives of American pet owners. Indiana University, Bloomington
93.
Walther B, Hermes J, Cuny C et al (2012) Sharing more than friendship – nasal colonization with coagulase-positive Staphylococci (CPS) and co-habitation aspects of dogs and their owners. PLoS One 7:e35197PubMedPubMedCentralCrossRef
94.
Sasaki T, Hirai I, Niki M et al (2010) High prevalence of CTX-M beta-lactamase-producing Enterobacteriaceae in stool specimens obtained from healthy individuals in Thailand. J Antimicrob Chemother 65:666–668PubMedCrossRef
95.
Luvsansharav UO, Hirai I, Nakata A et al (2012) Prevalence of and risk factors associated with faecal carriage of CTX-M beta-lactamase-producing Enterobacteriaceae in rural Thai communities. J Antimicrob Chemother 67:1769–1774PubMedCrossRef
96.
Boonyasiri A, Tangkoskul T, Seenama C, Saiyarin J, Tiengrim S, Thamlikitkul V (2014) Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand. Pathog Glob Health 108:235–245PubMedPubMedCentralCrossRef
97.
Hsueh PR, Hoban DJ, Carmeli Y et al (2011) Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region. J Infect 63:114–123PubMedCrossRef
98.
Bajpai T, Shrivastava G, Bhatambare GS, Deshmukh AB, Chitnis V (2013) Microbiological profile of lower respiratory tract infections in neurological intensive care unit of a tertiary care center from Central India. J Basic Clin Pharm 4:51–55PubMedPubMedCentralCrossRef
99.
Kumarasamy KK, Toleman MA, Walsh TR et al (2010) Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597–602PubMedPubMedCentralCrossRef
100.
Boxall AB, Rudd MA, Brooks BW et al (2012) Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect 120:1221–1229PubMedPubMedCentralCrossRef
101.
102.
Johnning A, Moore ER, Svensson-Stadler L, Shouche YS, Larsson DG, Kristiansson E (2013) Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production. Appl Environ Microbiol 79:7256–7263PubMedPubMedCentralCrossRef
103.
Rutgersson C, Fick J, Marathe N et al (2014) Fluoroquinolones and qnr genes in sediment, water, soil, and human fecal flora in an environment polluted by manufacturing discharges. Environ Sci Technol 48:7825–7832PubMedCrossRef
104.
Ahmad A, Patel I, Mohanta G, Balkrishnan R (2014) Evaluation of self medication practices in rural area of town Sahaswan at northern India. Ann Med Health Sci Res 4:S73–S78CrossRef
105.
Ahammad ZS, Sreekrishnan TR, Hands CL, Knapp CW, Graham DW (2014) Increased waterborne blaNDM-1 resistance gene abundances associated with seasonal human pilgrimages to the upper Ganges river. Environ Sci Technol 48:3014–3020PubMedPubMedCentralCrossRef
106.
Larsson DG (2014) Pollution from drug manufacturing: review and perspectives. Philos Trans R Soc Lond B Biol Sci 369(1656) doi: 10.1098/rstb.2013.0571
107.
Graham DW, Collignon P, Davies J, Larsson DG, Snape J (2014) Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environ Sci Technol 48:11746–11747PubMedCrossRef
108.
Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DG (2014) Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Front Microbiol 5:648PubMedPubMedCentralCrossRef
109.
Larsson DG, de Pedro C, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751–755PubMedCrossRef
110.
Lubbert C, Lippmann N, Busch T et al (2014) Long-term carriage of Klebsiella pneumoniae carbapenemase-2-producing K. pneumoniae after a large single-center outbreak in Germany. Am J Infect Control 42:376–380PubMedCrossRef
111.
Jans B, Daniel Huang TD, Bauraing C et al (2015) Infection due to travel-related carbapenemase-producing Enterobacteriaceae, a largely underestimated phenomenon in Belgium. Acta Clin Belg 70(3):181–187. doi:10.1179/2295333715Y.0000000001PubMedCrossRef
112.
Osterblad M, Kirveskari J, Hakanen AJ, Tissari P, Vaara M, Jalava J (2012) Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008–11). J Antimicrob Chemother 67:2860–2864PubMedCrossRef
113.
Kocsis E, Savio C, Piccoli M, Cornaglia G, Mazzariol A (2013) Klebsiella pneumoniae harbouring OXA-48 carbapenemase in a Libyan refugee in Italy. Clin Microbiol Infect 19:E409–E411CrossRef
114.
Schubert S (2014) Identifizierung von Antibiotika in urbanen Abwassersystem – Akkumulation an Sediment und Klärschlamm. Präv Gesundheitsfr 9:171–174CrossRef
115.
116.
117.
Yahav D, Farbman L, Leibovici L, Paul M (2012) Colistin: new lessons on an old antibiotic. Clin Microbiol Infect 18:18–29PubMedCrossRef
118.
119.
Canton R, Akova M, Carmeli Y et al (2012) Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 18:413–431PubMedCrossRef
120.
Karageorgopoulos DE, Wang R, Yu XH, Falagas ME (2012) Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in gram-negative pathogens. J Antimicrob Chemother 67:255–268PubMedCrossRef
121.
Falagas ME, Grammatikos AP, Michalopoulos A (2008) Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther 6:593–600PubMedCrossRef
122.
Livermore DM, Warner M, Mushtaq S, Doumith M, Zhang J, Woodford N (2011) What remains against carbapenem-resistant enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents 37:415–419PubMedCrossRef
123.
Oostdijk EA, Smits L, de Smet AM, Leverstein-van Hall MA, Kesecioglu J, Bonten MJ (2013) Colistin resistance in gram-negative bacteria during prophylactic topical colistin use in intensive care units. Intensive Care Med 39:653–660PubMedCrossRef
124.
Daikos GL, Tsaousi S, Tzouvelekis LS et al (2014) Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother 58:2322–2328PubMedPubMedCentralCrossRef
125.
Tumbarello M, Viale P, Viscoli C et al (2012) Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 55:943–950PubMedCrossRef
126.
Durante-Mangoni E, Signoriello G, Andini R et al (2013) Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii: a multicenter, randomized clinical trial. Clin Infect Dis 57:349–358PubMedCrossRef
127.
Aydemir H, Akduman D, Piskin N et al (2013) Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia. Epidemiol Infect 141:1214–1222PubMedCrossRef
128.
Theuretzbacher U (2012) Pharmacokinetic and pharmacodynamic issues for antimicrobial therapy in patients with cancer. Clin Infect Dis 54:1785–1792PubMedCrossRef
129.
130.
131.
Idelevich EA, von Eiff C, Friedrich AW et al (2011) In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin. Antimicrob Agents Chemother 55:4416–4419PubMedPubMedCentralCrossRef
132.
Weisman LE, Thackray HM, Steinhorn RH et al (2011) A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis. Pediatrics 128:271–279PubMedCrossRef
133.
Romani AA, Baroni MC, Taddei S et al (2013) In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens. J Pept Sci 19:554–565PubMedCrossRef
134.
Roos D, Dijksman LM, Tijssen JG, Gouma DJ, Gerhards MF, Oudemans-van Straaten HM (2013) Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery. Br J Surg 100:1579–1588PubMedCrossRef
135.
de Smet AM, Bonten MJ, Kluytmans JA (2012) For whom should we use selective decontamination of the digestive tract? Curr Opin Infect Dis 25:211–217PubMedCrossRef
136.
Daneman N, Sarwar S, Fowler RA, Cuthbertson BH, Su DCSG (2013) Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis 13:328–341PubMedCrossRef
137.
Sinha B, van Assen S, Friedrich AW (2014) Important issues for perioperative systemic antimicrobial prophylaxis in surgery. Curr Opin Anaesthesiol 27:377–381PubMedCrossRef
138.
Huang SS, Septimus E, Kleinman K et al (2013) Targeted versus universal decolonization to prevent ICU infection. N Engl J Med 368:2255–2265PubMedCrossRef
139.
Climo MW, Yokoe DS, Warren DK et al (2013) Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 368:533–542PubMedCrossRef
140.
Derde LP, Cooper BS, Goossens H et al (2014) Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. Lancet Infect Dis 14:31–39PubMedPubMedCentralCrossRef
141.
Schweickert B, Eckmanns T, Bärwolff S, Wischnewski N, Meyer E (2014) Surveillance des Antibiotikaverbrauchs in Krankenhäusern – Aufgaben des öffentlichen Gesundheitsdienstes. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57
142.
de With K, Allerberger F, Amann S et al (2013) S3 Leitlinie: Strategien zur Sicherung rationaler Antibiotika-Anwendung im Krankenhaus. AWMF Registernummer 092/001, Version 15. 12. 2013
Metadaten
Titel
Antibiotika-resistente Erreger in Deutschland
Die Rolle von nicht nosokomialen Ansteckungsquellen
verfasst von
Evgeny A. Idelevich
Christian Lanckohr
Dagmar Horn
Lothar H. Wieler
Karsten Becker
Priv.-Doz. Dr. med Robin Köck
Publikationsdatum
01.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz / Ausgabe 1/2016
Print ISSN: 1436-9990
Elektronische ISSN: 1437-1588
DOI
https://doi.org/10.1007/s00103-015-2261-z

Weitere Artikel der Ausgabe 1/2016

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 1/2016 Zur Ausgabe

Leitthema

Gewalt und Diskriminierung am Arbeitsplatz

Leitthema

Substanzbezogene Störungen als Ursache und als Folge früher Gewalt

Leitthema

Trauma- und Gewaltfolgen – psychische Auswirkungen

Leitthema

Gewalt und Gesundheit

Leitthema

Gewalt durch psychisch Kranke und gegen psychisch Kranke

Leitthema

Gewalt gegen alte Menschen

Leitlinien kompakt für die Allgemeinmedizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Facharzt-Training Allgemeinmedizin

Die ideale Vorbereitung zur anstehenden Prüfung mit den ersten 24 von 100 klinischen Fallbeispielen verschiedener Themenfelder

Mehr erfahren

Neu im Fachgebiet Allgemeinmedizin

23.04.2024 | Prävention und Rehabilitation in der Kardiologie | Nachrichten

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

23.04.2024 | Leitsymptom Rückenschmerzen | Nachrichten

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 | Demenz | Nachrichten

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 | Parkinson-Krankheit | Podcast | Nachrichten

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus
Professorin Dr. Claudia Trenkwalder, Neurologin
weitere anzeigen

Update Allgemeinmedizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise