Skip to main content
SpringerLink
Log in

Topische Therapie von entzündlichen Dermatosen, Juckreiz und Schmerz sowie Hyperhidrose

Topical therapy of inflammatory dermatoses, pruritus and pain, as well as hyperhidrosis

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

In dieser Übersicht werden die Inhaltsstoffe, die zur topischen Behandlung von entzündlichen Dermatosen, Juckreiz, Schmerzen und Hyperhidrose verwendet werden können, dargestellt. Neben mehr unspezifisch wirkenden Externa werden die spezifisch antientzündlich wirkenden Externa Glukokortikoide, Calcineurin-Inhibitoren, Dithranol, Pix lithanthracis, Liquor carbonis detergens, Vitamin-D-Analoga, Metronidazol, Azelainsäure, topische Retinoide und Benzoylperoxid bezüglich ihrer Wirkungen, Indikationen und Nebenwirkungen besprochen. Zusätzlich werden praktische Empfehlungen zur Behandlung dieser häufigen Dermatosen gegeben.

Abstract

In this review, substances suitable for the topical treatment of inflammatory dermatoses, pruritus, pain and hyperhidrosis are presented. Both non-specific and specific topical treatments are discussed with respect to their mode of action, indications and side effects; included are corticosteroids, calcineurin inhibitors, dithranol, coal tar, liquor carbonis detergens, vitamin D analogues, metronidazole, azelaic acid, retinoids, and benzoyl peroxide. Additionally, practical directions for the treatment of these common skin diseases are provided.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Arnold WP (1997) Tar. Clin Dermatol 15:739–744

    Article  CAS  PubMed  Google Scholar 

  2. Austad J, Bjerke JR, Gjertsen BT et al (1998) Clobetasol propionate followed by calcipotriol is superior to calcipotriol alone in topical treatment of psoriasis. J Eur Acad Dermatol Venereol 11:19–24

    Article  CAS  PubMed  Google Scholar 

  3. Derry S, Moore RA, Rabbie R (2012) Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev 9:CD007400

    PubMed  Google Scholar 

  4. Galewski E (1916) Über Cignolin, ein Ersatzpräparat des Chrysarobins. Dermatol Wochenschr 62:113–115

    Google Scholar 

  5. Eschler DC, Klein PA (2010) An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. J Drugs Dermatol 9:992–997

    PubMed  Google Scholar 

  6. Exley C (1998) Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer’s disease? Mol Med Today 4:107–109

    Article  CAS  PubMed  Google Scholar 

  7. Fluhr JW, Nast A (2011) Maintenance therapy: acne as a chronic disease. Br J Dermatol 164:1181–1182

    Article  CAS  PubMed  Google Scholar 

  8. Foti C, Calogiuri G, Cassano N et al (2009) Contact allergy to topical corticosteroids: update and review on cross-sensitization. Recent Pat Inflamm Allergy Drug Discov 3:33–39

    Article  CAS  PubMed  Google Scholar 

  9. Unna PG (1916) Cignolin als Heilmittel der Psoriasis. Dermatol Wochenschr 62:116–137, 150–163, 175–183

    Google Scholar 

  10. Gall HM, Paul E (2001) A case of corticosteroid allergy. Hautarzt 52:891–894

    Article  CAS  PubMed  Google Scholar 

  11. Genebriera J, Davis MD, Yang H et al (2007) Papillomatous axillary rash due to granular parakeratosis. J Eur Acad Dermatol Venereol 21:994–995

    Article  CAS  PubMed  Google Scholar 

  12. Green L, Sadoff W (2002) A clinical evaluation of tazarotene 0.1 % gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis. J Cutan Med Surg 6:95–102

    Article  PubMed  Google Scholar 

  13. Holzle E, Braun-Falco O (1984) Structural changes in axillary eccrine glands following long-term treatment with aluminium chloride hexahydrate solution. Br J Dermatol 110:399–403

    Article  CAS  PubMed  Google Scholar 

  14. Ikoma A, Rukwied R, Stander S et al (2003) Neurophysiology of pruritus: interaction of itch and pain. Arch Dermatol 139:1475–1478

    PubMed  Google Scholar 

  15. Joly P, Roujeau JC, Benichou J et al (2009) A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study. J Invest Dermatol 129:1681–1687

    Article  CAS  PubMed  Google Scholar 

  16. Joly P, Roujeau JC, Benichou J et al (2002) A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. N Engl J Med 346:321–327

    Article  CAS  PubMed  Google Scholar 

  17. Kaufmann R, Bibby AJ, Bissonnette R et al (2002) A new calcipotriol/betamethasone dipropionate formulation (Daivobet) is an effective once-daily treatment for psoriasis vulgaris. Dermatology 205:389–393

    Article  CAS  PubMed  Google Scholar 

  18. Koo J, Cuffie CA, Tanner DJ et al (1998) Mometasone furoate 0.1 %-salicylic acid 5 % ointment versus mometasone furoate 0.1 % ointment in the treatment of moderate-to-severe psoriasis: a multicenter study. Clin Ther 20:283–291

    Article  CAS  PubMed  Google Scholar 

  19. Kuhn A, Ruland V, Bonsmann G (2011) Cutaneous lupus erythematosus: update of therapeutic options part II. J Am Acad Dermatol 65:e195–e213

    Article  PubMed  Google Scholar 

  20. Liao YH, Chiu HC, Tseng YS et al (2007) Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(− 1) ointment and tacrolimus 0.3 mg g(− 1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. Br J Dermatol 157:1005–1012

    Article  CAS  PubMed  Google Scholar 

  21. Luger T, Loske KD, Elsner P et al (2004) Topical skin therapy with glucocorticoids – therapeutic index. J Dtsch Dermatol Ges 2:629–634

    Article  PubMed  Google Scholar 

  22. Manousaridis I, Manousaridis K, Peitsch WK et al (2013) Individualizing treatment and choice of medication in lichen planus: a step by step approach. J Dtsch Dermatol Ges 11:981–991

    Google Scholar 

  23. Mason J, Mason AR, Cork MJ (2002) Topical preparations for the treatment of psoriasis: a systematic review. Br J Dermatol 146:351–364

    Article  CAS  PubMed  Google Scholar 

  24. Massey T, Derry S, Moore RA et al (2010) Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev CD007402

  25. Mcwilliams SA, Montgomery I, Jenkinson DM et al (1987) Effects of topically-applied antiperspirant on sweat gland function. Br J Dermatol 117:617–626

    Article  CAS  PubMed  Google Scholar 

  26. Nast A, Bayerl C, Borelli C et al (2010) S2k-guideline for therapy of acne. J Dtsch Dermatol Ges 8(Suppl 2):s1–s59

    PubMed  Google Scholar 

  27. Nast A, Boehncke WH, Mrowietz U et al (2012) German S3-guidelines on the treatment of psoriasis vulgaris (short version). Arch Dermatol Res 304:87–113

    Article  CAS  PubMed  Google Scholar 

  28. Neill SM, Lewis FM, Tatnall FM et al (2010) British Association of Dermatologists‘ guidelines for the management of lichen sclerosus 2010. Br J Dermatol 163:672–682

    Article  CAS  PubMed  Google Scholar 

  29. Phan NQ, Siepmann D, Gralow I et al (2010) Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia. J Dtsch Dermatol Ges 8:88–91

    Article  PubMed  Google Scholar 

  30. Reimann S, Luger T, Metze D (2000) Topical administration of capsaicin in dermatology for treatment of itching and pain. Hautarzt 51:164–172

    Article  CAS  PubMed  Google Scholar 

  31. Reinholz M, Tietze JK, Kilian K et al (2013) Rosacea – S1 guideline. J Dtsch Dermatol Ges 11:768–780

    PubMed  Google Scholar 

  32. Ring J, Alomar A, Bieber T et al (2012) Guidelines for treatment of atopic eczema (atopic dermatitis) part II. J Eur Acad Dermatol Venereol 26:1176–1193

    Article  CAS  PubMed  Google Scholar 

  33. Runne U, Kunze J (1982) Short-duration („minutes“) therapy with dithranol for psoriasis: a new out-patient regimen. Br J Dermatol 106:135–139

    Article  CAS  PubMed  Google Scholar 

  34. Stander S, Darsow U, Mettang T et al (2012) S2k guideline – chronic pruritus. J Dtsch Dermatol Ges 10(Suppl 4):S1–S27

    Article  PubMed  Google Scholar 

  35. Stander S, Reinhardt HW, Luger TA (2006) Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus. Hautarzt 57:801–807

    Article  CAS  PubMed  Google Scholar 

  36. Streker M, Kerscher M (2012) Antiperspirants for the therapy of focal hyperhidrosis. Hautarzt 63:452–455

    Article  CAS  PubMed  Google Scholar 

  37. Thaci D, Kaufmann R, Bieber T et al (2010) Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1 % is applied under occlusion. Dermatology 221:342–351

    Article  PubMed  Google Scholar 

  38. Tomljenovic L (2011) Aluminum and Alzheimer’s disease: after a century of controversy, is there a plausible link? J Alzheimers Dis 23:567–598

    CAS  PubMed  Google Scholar 

  39. Wollenberg A, Bieber T, Dirschka T et al (2011) Perioral dermatitis. J Dtsch Dermatol Ges 9:422–427

    PubMed  Google Scholar 

  40. Wollenberg A, Reitamo S, Atzori F et al (2008) Proactive treatment of atopic dermatitis in adults with 0.1 % tacrolimus ointment. Allergy 63:742–750

    Article  CAS  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. K. Schultheis, A. Messerschmidt und F. Ochsendorf geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/M., Deutschland

    K. Schultheis, A. Messerschmidt &  F. Ochsendorf

Authors
  1. K. Schultheis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Messerschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Ochsendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. Ochsendorf.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schultheis, K., Messerschmidt, A. & Ochsendorf, F. Topische Therapie von entzündlichen Dermatosen, Juckreiz und Schmerz sowie Hyperhidrose. Hautarzt 65, 197–206 (2014). https://doi.org/10.1007/s00105-013-2658-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-013-2658-2

Schlüsselwörter

Keywords

Search

Navigation