Zusammenfassung
Obwohl Tinnitus zumeist durch Schädigung der Haarzellen des Innenohrs primär peripher generiert wird, entstehen Belastung und Leiden erst durch die zentrale Verarbeitung und Vernetzung bei zerebraler Plastizität. Neuere Therapieansätze versuchen daher, diese Strukturen zu beeinflussen, sei es direkt durch magnetische Bestrahlung oder direkte und indirekte elektrische Stimulation. Auch akustische Stimulationen sind vorgestellt worden, mit Tönen oder veränderter Musik, sie müssen aber den oft bestehenden Hörverlust in die Rehabilitation einbeziehen. Wirksame Habituationstherapien arbeiten mit Hörtherapie, einem Ausgleich des Hörverlusts durch Hörgeräte und psychischer Stabilisierung. In der vorliegenden Übersicht werden die verschiedenen Therapieansätze vorgestellt.
Abstract
In the majority of cases, tinnitus derives primarily peripherally, from damage to hair cells in the inner ear; suffering and annoyance, however, are caused by central cortical processing and functional networks of cerebral plasticity. Therefore, new therapeutic approaches aim to influence these structures; whether it be directly by magnetic radiation, or via direct or indirect electrical stimulation. However, these methods can only be efficient if they can integrate and rehabilitate the existing hearing loss. Effective habituation therapies consist of hearing therapy, rehabilitation of hearing loss by hearing aids and psychosomatic stabilisation. In this review, different therapeutic approaches are described and valuated.
Literatur
Klemm E, Deutscher A, Mösges R (2009) Aktuelle Stichprobe zur Epidemiologie des idiopathischen Hörsturzes. Laryngorhinootologie 88:524–527
AWMF (2014) Leitlinie Hörsturz. Leitlinien der Dtsch Ges f Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie. Leitlinie 017/010, http://www.awmf.org/leitlinien/detail/ll/017-010.html. Zugegriffen: 3. März 2015
Egli Gallo D, Khojasteh E, Gloor M et al (2013) Effectiveness of systemic high-dose dexamethasone therapy for idiopathic sudden sensorineural hearing loss. Audiol Neurootol 18:161–170
Alexiou C, Arnold W, Fauser C et al (2001) Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg 127:253–258
Westerlaken BO, Kleine E de, Laan B van der et al (2007) The treatment of idiopathic sudden sensorineural hearing loss using pulse therapy: a prospective, randomized, double-blind clinical trial. Laryngoscope 117:684–690
Lee JB, Choi SJ, Park K et al (2011) The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 268:833–839
Garavello W, Galluzzi F, Gaini R et al (2012) Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials. Otol Neurotol 33:724–729
Plontke SK MC, Caye-Thomasen P, Agrawal S, Mikulec T (2009) A systematic review and metaanalysis of intratympanic glucocorticosteroids for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev (Protocol), Issue 4. doi:101002/14651858CD008080 (Full Review 2013; under review)
Wu RX, Chen CC, Wang CH et al (2013) Intratympanic steroid injection for sudden sensorineural hearing loss in a patient on hemodialysis. Hemodial Int 18(1):195–199
Plontke SK, Glien A, Rahne T et al (2014) Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol 35:1168–1171
Wei BP, Stathopoulos D, O’Leary S (2013) Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev 7:CD003998
Agarwal L, Pothier D (2009) Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev 4
Drew S, Davies E (2001) Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. BMJ 322:73–79
Laubert A (2008) Therapie des akuten Tinnitus. In: Hebing G (Hrsg) Tinnitus. Thieme, Stuttgart, S 62–72
Hesse G (2009) Tinnitus. In: Lehnhardt E, Laszig R (Hrsg) Praxis der Audiometrie, 9. Aufl. Thieme, Stuttgart, S 163–171
Hesse G (2012) Anxiolytics do not reduce dizziness, they reduce fear and have harmful side-effects! Acta Otolaryngol 132:903 (author reply 904–905)
Schaaf H, Eichenberg C, Kastellis G et al (2010) Treatment of tinnitus needs a combined neurootological and psychosomatic approach. Otolaryngol Pol 64:78–82
Hesse G, Laubert A (2010) Pharmacotherapy of acute and chronic hearing loss. HNO 58:990–998
Pilgramm M, Rychlick R, Lebisch H et al (1999) Tinnitus in the Federal Republic of Germany: a representative epidemiological study. In: Hazell J (Hrsg) Proceedings of the sixth International Tinnitus Seminar. Cambridge, S 64–67
Schaaf H, Dölberg D, Seling B, Märtner M (2010) Komorbidität von Tinnituserkrankungen und psychiatrischen Störungen. Nervenarzt 74:72–75
Norena A (2010) An integrative model of tinnitus based on a central gain controlling neural sensitivity. Neurosci Biobehav Rev 35(5):1089–1109
Mazurek B, Haupt H, Olze H et al (2012) Stress and tinnitus-from bedside to bench and back. Front Syst Neurosci 6:1–8
Eggermont J (2013) Hearing loss, hyperacusis, or tinnitus: what is modeled in animal research? Hear Res 295:140–149
Hesse G, Eichhorn S, Laubert A (2014) Hearing function and hearing loss in the elderly. HNO 62(9):630–639
Hesse G, Laubert A (2005) Hörminderung im Alter – Ausprägung und Lokalisation. Dtsch Arztebl 42:A2864–A2868
Mazurek B, Haupt H, Joachim R et al (2010) Stress induces transient auditory hypersensitivity in rats. Hear Res 259:55–63
Eggermont JJ (2006) Cortical tonotopic map reorganization and its implications for treatment of tinnitus. Acta Otolaryngol 126:9–12
Buss E, Hall JW III, Grose JH et al (1998) Perceptual consequences of peripheral hearing loss: do edge effects exist for abrupt cochlear lesions? Hear Res 125(1–2):98–108
Eggermont J, Roberts L (2012) The Neuroscience of tinnitus: understanding abnormal and normal auditory perception. Front Syst Neurosci 6:53
Pienkowski M, Eggermont J (2012) Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure. Ear Hear 33:305–314
Diesch E, Schummer V, Kramer M et al (2012) Structural changes of the corpus callosum in tinnitus. Front Syst Neurosci 6:17
Song JJ, De Ridder D, Heyning P van de, Vanneste S (2012) Mapping tinnitus-related brain activation: an activation-likelihood estimation metaaanalysis of PET studies. J Nucl Med 53(10):1550–1557
Adjamian P, Sereda M, Zobay O et al (2012) Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss. J Assoc Res Otolaryngol 13(5):715–731
Vanneste S, De Ridder D (2012) The auditory and non-auditory brain areas involved in tinnitus. An emergent property of multiple prallel overlapping subnetworks. Front Syst Neurosci 6:31
Tyler R (2012) Patient preferences and willingness to pay for tinnitus treatments. J Am Acad Audiol 23:115–125
Engineer N, Rosellini W, Tyler R (2012) Willingness to accept and pay for implantable tinnitus treatments: a survey. Neuromodulation 16(2):154–162
Plewnia C (2011) Brain stimulation: new vistas for the exploration and treatment of tinnitus. CNS Neurosci Ther 17:449–461
Langguth B, Landgrebe M, Frank E et al (2012) Efficacy of different protocols of transcranial magnetic stimulation for the treatment of tinnitus: pooled analysis of two randomized controlled studies. World J Biol Psychiatry 15(4):276–285
Burger J, Frank E, Kreuzer P et al (2011) Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders-a retrospective analysis. Brain Stimul 4:222–227
Plewnia C, Vonthein R, Wasserka B et al (2012) Treatment of chronic tinnitus with theta burst stimulation: a randomized controlled trial. Neurology 78(21):1628–1634
Tringali S, Perrot X, Collet L et al (2012) Repetitive transcranial magnetic stimulation noise levels: methodological implications for tinnitus treatment. Otol Neurotol 33:1156–1160
De Ridder D, Vanneste S, Plazier M et al (2011) Dorsolateral prefrontal cortex transcranial magnetic stimulation and electrode implant for intractable tinnitus. World Neurosurg 77(5–6):778–784
De Ridder D, Vanneste S (2014) Targeting the parahippocampal area by auditory cortex stimulation in tinnitus. Brain Stimul 7(5):709–717
Arndt S, Laszig R, Aschendorff A et al (2011) Einseitige Taubheit und Cochleaimplantat-Versorgung. HNO 59:437–446
Jacob R, Stelzig Y, Nopp P et al (2011) Audiological results with cochlear implants for single-sided deafness. HNO 59:453–460
Olze H, Szczepek A, Haupt H et al (2011) Cochlear implantation has a positive influence on quality of life, tinnitus, and psychological comorbidity. Laryngoscope 121:2220–2227
Tass P, Adamchic I, Freund H et al (2012) Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restor Neurol Neurosci 30(2):137–159
Mühlnickel W, Elbert T, Taub E et al (1998) Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci 95(17):10340–10343
Flor H, Hoffmann D, Struve M et al (2004) Auditory discrimination training for the treatment of tinnitus. Appl Psychophysiol Biofeedback 29:113–120
Hoare DJ, Pierzycki RH, Thomas H et al (2012) Evaluation of the acoustic coordinated reset (CR (R)) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial. Trials 14:207
Hesse G (2010) Neurostimulation und Musiktherapie bei chronischem Tinnitus – neue wirksame Verfahren? Z Audiol 49:86–89
Engineer N, Riley J, Seale J et al (2011) Reversing pathological neural activity using targeted plasticity. Nature 189:207–214
Kreuzer P, Landgrebe M, Husser O et al (2012) Transcutaneous vagus nerve stimulation: retrospective assessment of cardiac safety in a pilot study. Front Psychiatry 3:70
Cramer A (2002) Tinnitus: Musiktherapie. Trias, Stuttgart
Argstatter H, Krick C, Bolay HV (2008) Musiktherapie bei chronisch-tonalem Tinnitus. Heidelberger Modell evidenzbasierter Musiktherapie. HNO 56:678–685
Pantev C, Okamoto H, Teismann H (2012) Music-induced cortical plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment. Front Syst Neurosci 6:50
Teismann H, Okamoto H, Pantev C (2011) Short and intense Tailor-made notched music training against tinnitus: thre frequency matters. PLoS One 6:e24685
Olze H, Zahnert T, Hesse G (2010) Hearing aids, implantable hearing aids and cochlear implants in chronic tinnitus therapy. HNO 58:1004–1012
Moffat G, Adjout K, Gallego S et al (2009) Effects of hearing aid fitting on the perceptual characteristics of tinnitus. Hear Res 254:82–91
Hoare DJ, Edmondson-Jones M, Sereda M et al (2014) Amplification with hearing aids for patients with tinnitus and co-existing hearing loss. Cochrane Database Syst Rev 1:CD010151
Hesse G (2001) Therapeutische Ansätze zur Verbesserung der auditiven Perzeption. In: Biesinger E, Iro H (Hrsg) HNO-Praxis heute 21. Springer, Berlin, S 197–211
Ptok M, Meyer S, Ptok A (2012) Hearing training, hearing therapy and auditory rehabilitation in hearing impaired individuals during the last few centuries. HNO 60:913–918
Hesse G, Schaaf H (2012) Manual der Hörtherapie. Thieme, Stuttgart
Suckfull M, Althaus M, Ellers-Lenz B et al (2011) A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC Ear Nose Throat Disord 11:1
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Interessenkonflikt. G. Hesse gibt an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben. Im Falle von nicht mündigen Patienten liegt die Einwilligung eines Erziehungsberechtigen oder des gesetzlich bestellten Betreuers vor.
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Hesse, G. Neueste Behandlungsansätze bei chronischem Tinnitus. HNO 63, 283–290 (2015). https://doi.org/10.1007/s00106-014-2972-8
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DOI: https://doi.org/10.1007/s00106-014-2972-8