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The expansive role of oxylipins on platelet biology

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Abstract

In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated.

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Authors and Affiliations

  1. Department of Pharmacology, University of Michigan, 1150 W. Medical Center Dr., Room 2220D, Ann Arbor, MI, 48109-5632, USA

    Jennifer Yeung, Megan Hawley & Michael Holinstat

  2. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA

    Michael Holinstat

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  1. Jennifer Yeung
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  2. Megan Hawley
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Correspondence to Michael Holinstat.

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This work was supported in part, by the National Institutes of Health Office of Dietary Supplement, R01 GM105671 (MH), R01 HL114405 (MH), and F31 HL129481 (JY).

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Yeung, J., Hawley, M. & Holinstat, M. The expansive role of oxylipins on platelet biology. J Mol Med 95, 575–588 (2017). https://doi.org/10.1007/s00109-017-1542-4

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