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01.10.2009 | Wachstum und Entwicklung | Konsensuspapiere

Leitlinie zur Diagnostik des Wachstumshormonmangels im Kindes- und Jugendalter

verfasst von: Prof. Dr. G. Binder, J.H. Brämswig, J. Kratzsch, R. Pfäffle, J. Woelfle, Arbeitsgemeinschaft Pädiatrische Endokrinologie und Diabetologie (APE)

Erschienen in: Monatsschrift Kinderheilkunde | Ausgabe 10/2009

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Zusammenfassung

Zentrales Ziel der in diesem Beitrag vorgestellten Leitlinie ist, auf Basis der vorhandenen Evidenz und im Konsensusverfahren klare Einschlusskriterien für die Diagnostik des Wachstumshormonmangels im Kindes- und Jugendalter zu benennen, die dazu geeignet sind, die Rate falsch-positiver Testresultate zu reduzieren. Darüber hinaus sollen Empfehlungen für eine Vereinheitlichung der Test- und Messverfahren gegeben werden. Die Diagnose Wachstumshormonmangel im Kindes- und Jugendalter soll nur dann gestellt werden, wenn bei Erfüllung der in diesen Leitlinien genannten auxologischen, klinischen, radiologischen und laborchemischen Kriterien zusätzlich 2 pathologische Wachstumshormonstimulationstests vorliegen. Im Neugeborenen- und Säuglingsalter sollen keine Wachstumshormonstimulationstests angewandt werden, sondern eine basale Messung von IGFBP-3 und 3–4 basale Wachstumshormonmessungen erfolgen. IGFBP-3-Werte <−2,0 SDS machen einen Wachstumshormonmangel in diesem Alter wahrscheinlich. Magnetresonanztomographisch nachgewiesene morphologische Veränderungen können deutliche Hinweise auf das Vorliegen eines Wachstumshormonmangels geben.

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Titel: Leitlinie zur Diagnostik des Wachstumshormonmangels im Kindes- und Jugendalter
verfasst von: Prof. Dr. G. Binder
J.H. Brämswig
J. Kratzsch
R. Pfäffle
J. Woelfle
Arbeitsgemeinschaft Pädiatrische Endokrinologie und Diabetologie (APE)
Publikationsdatum: 01.10.2009
Verlag: Springer-Verlag
Schlagwörter: Wachstum und Entwicklung
Pädiatrische Diagnostik
Erschienen in: Monatsschrift Kinderheilkunde / Ausgabe 10/2009
Print ISSN: 0026-9298
Elektronische ISSN: 1433-0474
DOI: https://doi.org/10.1007/s00112-009-2049-z

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