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Erschienen in: Der Urologe 9/2005

01.09.2005 | Weiterbildung · Zertifizierte Fortbildung

Harnblasentumoren

Die neue WHO-Klassifikation 2004

verfasst von: Dr. med. M. Seitz, D. Zaak, R. Knüchel-Clarke, C. Stief

Erschienen in: Die Urologie | Ausgabe 9/2005

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Zusammenfassung

Im Bereich der molekulargenetischen Forschung am Harnblasenkarzinom gibt es zunehmend Erkenntnisse, die uns helfen, dass morphologische Bild besser zu verstehen und anders zu klassifizieren. Wegweisend und zielführend wird dieses neue Wissen nur dann sein, wenn es mit dem klinischen Verlauf der Harnblasentumoren und der Histopathologie korreliert werden kann. Die konsequente Verwendung der neuen Klassifikation (WHO-Klassifikation 2004) resultiert in einer einheitlichen Diagnose der Urotheltumoren durch die scharfe Definition der Subgruppierung, sodass in Zukunft weltweit Studien miteinander verglichen und Risikoprofile stratifiziert werden können. Durch weitere Forschung im Bereich der Molekulargenetik und Korrelation mit der aktuellen Klassifikation kann sich durch molekularbiologische Techniken eine Verfeinerung dieses Schemas durch z. B. immunhistochemische Subklassifizierungen ergeben, um potenziell genetisch instabile Tumoren herauszufiltern. Ziel dieser Arbeit ist die Präsentation der neuen WHO-Klassifikation der Harnblasentumoren 2004 mit ihren Änderungen vergleichend zu den vorangegangen Klassifikationen mit dem Fokus auf histologische Typisierung, Grading und molekulare Charakterisierung. Bis zur endgültigen Validierung und bis zum „Erlernen“ der neuen Klassifikation soll weiterhin die WHO-Klassifikation von 1973 im histopathologischen Befund ergänzend erwähnt werden.
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Metadaten
Titel
Harnblasentumoren
Die neue WHO-Klassifikation 2004
verfasst von
Dr. med. M. Seitz
D. Zaak
R. Knüchel-Clarke
C. Stief
Publikationsdatum
01.09.2005
Verlag
Springer-Verlag
Erschienen in
Die Urologie / Ausgabe 9/2005
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-005-0901-x

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