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Erschienen in: Diabetologia 11/2003

01.11.2003 | Article

Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women

verfasst von: M. B. Schulze, J. E. Manson, W. C. Willett, F. B. Hu

Erschienen in: Diabetologia | Ausgabe 11/2003

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Abstract

Aim/hypothesis

The aim of this study was to investigate the association between processed and other meat intake and incidence of Type 2 diabetes in a large cohort of women.

Methods

Incident cases of Type 2 diabetes were identified during 8 years of follow-up in a prospective cohort study of 91246 U.S. women aged 26 to 46 years and being free of diabetes and other major chronic diseases at baseline in 1991.

Results

We identified 741 incident cases of confirmed Type 2 diabetes during 716276 person-years of follow-up. The relative risk adjusted for potential non-dietary confounders was 1.91 (95% CI: 1.42–2.57) in women consuming processed meat five times or more a week compared with those consuming processed meat less than once a week (p<0.001 for trend). Further adjustment for intakes of magnesium, cereal fibre, glycaemic index, and caffeine or for a Western dietary pattern did not appreciably change the results and associations remained strong after further adjustment for fatty acid and cholesterol intake. Frequent consumption of bacon, hot dogs, and sausage was each associated with an increased risk of diabetes. While total red meat (beef or lamb as main dish, pork as main dish, hamburger, beef, pork or lamb as sandwich or mixed dish) intake was associated with an increased risk of diabetes, this association was attenuated after adjustment for magnesium, cereal fiber, glycaemic index, and caffeine (relative risk: 1.44; 95% CI: 0.92–2.24).

Conclusion/interpretation

Our data suggest that diets high in processed meats could increase the risk for developing Type 2 diabetes.
Literatur
1.
Zurück zum Zitat Centers for Disease Control and Prevention (2002) National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2000. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA Centers for Disease Control and Prevention (2002) National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2000. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA
2.
Zurück zum Zitat Mokdad AH, Ford ES, Bowman BA et al. (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76–79CrossRefPubMed Mokdad AH, Ford ES, Bowman BA et al. (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76–79CrossRefPubMed
3.
Zurück zum Zitat Mokdad AH, Ford ES, Bowman BA et al. (2000) Diabetes trends in the US: 1990–1998. Diabetes Care 23:1278–1283PubMed Mokdad AH, Ford ES, Bowman BA et al. (2000) Diabetes trends in the US: 1990–1998. Diabetes Care 23:1278–1283PubMed
4.
Zurück zum Zitat Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195–1200PubMed Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195–1200PubMed
5.
Zurück zum Zitat Cho E, Rimm EB, Stampfer MJ, Willett WC, Hu FB (2002) The impact of diabetes mellitus and prior myocardial infarction on mortality from all causes and from coronary heart disease in men. J Am Coll Cardiol 40:954–960CrossRefPubMed Cho E, Rimm EB, Stampfer MJ, Willett WC, Hu FB (2002) The impact of diabetes mellitus and prior myocardial infarction on mortality from all causes and from coronary heart disease in men. J Am Coll Cardiol 40:954–960CrossRefPubMed
6.
Zurück zum Zitat WHO (2002) The World Health Report 2002: reducing risks, promoting healthy life. WHO, Geneva WHO (2002) The World Health Report 2002: reducing risks, promoting healthy life. WHO, Geneva
7.
Zurück zum Zitat Anonymous (2003) Economic Costs of Diabetes in the US in 2002. Diabetes Care 26:917–932PubMed Anonymous (2003) Economic Costs of Diabetes in the US in 2002. Diabetes Care 26:917–932PubMed
8.
Zurück zum Zitat Astrup A, Finer N (2000) Redefining type 2 diabetes: ‘diabesity’ or ‘obesity dependent diabetes mellitus’? Obes Rev 1:57–59CrossRefPubMed Astrup A, Finer N (2000) Redefining type 2 diabetes: ‘diabesity’ or ‘obesity dependent diabetes mellitus’? Obes Rev 1:57–59CrossRefPubMed
9.
Zurück zum Zitat Paffenbarger RS Jr, Lee IM, Kampert JB (1997) Physical activity in the prevention of non-insulin-dependent diabetes mellitus. World Rev Nutr Diet 82:210–218PubMed Paffenbarger RS Jr, Lee IM, Kampert JB (1997) Physical activity in the prevention of non-insulin-dependent diabetes mellitus. World Rev Nutr Diet 82:210–218PubMed
10.
Zurück zum Zitat Wei M, Schwertner HA, Blair SN (2000) The association between physical activity, physical fitness, and type 2 diabetes mellitus. Compr Ther 26:176–182PubMed Wei M, Schwertner HA, Blair SN (2000) The association between physical activity, physical fitness, and type 2 diabetes mellitus. Compr Ther 26:176–182PubMed
11.
Zurück zum Zitat Hu FB, Manson JE, Stampfer MJ et al. (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790–797CrossRefPubMed Hu FB, Manson JE, Stampfer MJ et al. (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790–797CrossRefPubMed
12.
Zurück zum Zitat Sherwin RS, Anderson RM, Buse JB et al. (2003) The prevention or delay of type 2 diabetes. Diabetes Care 26 (Suppl 1):S62–69PubMed Sherwin RS, Anderson RM, Buse JB et al. (2003) The prevention or delay of type 2 diabetes. Diabetes Care 26 (Suppl 1):S62–69PubMed
13.
Zurück zum Zitat Dam RM van, Willett WC, Rimm EB, Stampfer MJ, Hu FB (2002) Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 25:417–424PubMed Dam RM van, Willett WC, Rimm EB, Stampfer MJ, Hu FB (2002) Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 25:417–424PubMed
14.
Zurück zum Zitat Peppa M, Goldberg T, Cai W, Rayfield E, Vlassara H (2002) Glycotoxins: a missing link in the “Relationship of Dietary Fat and Meat Intake in Relation to Risk of Type 2 Diabetes in Men”. Diabetes Care 25:1898–1899PubMed Peppa M, Goldberg T, Cai W, Rayfield E, Vlassara H (2002) Glycotoxins: a missing link in the “Relationship of Dietary Fat and Meat Intake in Relation to Risk of Type 2 Diabetes in Men”. Diabetes Care 25:1898–1899PubMed
15.
Zurück zum Zitat Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13:3–9CrossRefPubMed Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13:3–9CrossRefPubMed
16.
Zurück zum Zitat Schulze MB, Hu FB (2002) Dietary patterns and risk of hypertension, type 2 diabetes mellitus, and coronary heart disease. Curr Atheroscler Rep 4:462–467PubMed Schulze MB, Hu FB (2002) Dietary patterns and risk of hypertension, type 2 diabetes mellitus, and coronary heart disease. Curr Atheroscler Rep 4:462–467PubMed
17.
Zurück zum Zitat van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB (2002) Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med 136:201–209PubMed van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB (2002) Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med 136:201–209PubMed
18.
Zurück zum Zitat Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE (1992) Diet and risk of clinical diabetes in women. Am J Clin Nutr 55:1018–1023PubMed Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE (1992) Diet and risk of clinical diabetes in women. Am J Clin Nutr 55:1018–1023PubMed
19.
Zurück zum Zitat Salmeron J, Ascherio A, Rimm EB et al. (1997) Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 20:545–550PubMed Salmeron J, Ascherio A, Rimm EB et al. (1997) Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 20:545–550PubMed
20.
Zurück zum Zitat Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277:472–477CrossRefPubMed Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277:472–477CrossRefPubMed
21.
Zurück zum Zitat US Department of Agriculture (1992) Composition of foods: raw, processed, prepared, 1963–1991. US Government Printing Office, Washington, DC US Department of Agriculture (1992) Composition of foods: raw, processed, prepared, 1963–1991. US Government Printing Office, Washington, DC
22.
Zurück zum Zitat Willett WC, Stampfer M (1998) Implications of total energy intake for epidemiologic analysis. In: Willett WC (ed.) Nutritional epidemiology. Oxford University Press, New York, pp 273–301 Willett WC, Stampfer M (1998) Implications of total energy intake for epidemiologic analysis. In: Willett WC (ed.) Nutritional epidemiology. Oxford University Press, New York, pp 273–301
23.
Zurück zum Zitat Salvini S, Hunter DJ, Sampson L et al. (1989) Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 18:858–867PubMed Salvini S, Hunter DJ, Sampson L et al. (1989) Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 18:858–867PubMed
24.
Zurück zum Zitat Willett WC, Lenart E (1998) Reproducibility and validity of food-frequency questionnaires. In: Willett WC (ed.) Nutritional epidemiology. Oxford University Press, New York, pp 101–156 Willett WC, Lenart E (1998) Reproducibility and validity of food-frequency questionnaires. In: Willett WC (ed.) Nutritional epidemiology. Oxford University Press, New York, pp 101–156
25.
Zurück zum Zitat National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057PubMed National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057PubMed
26.
Zurück zum Zitat Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183–1197PubMed Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183–1197PubMed
27.
Zurück zum Zitat Manson JE, Rimm EB, Stampfer MJ et al. (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774–778PubMed Manson JE, Rimm EB, Stampfer MJ et al. (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774–778PubMed
28.
Zurück zum Zitat Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB (2001) Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 161:1542–1548PubMed Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB (2001) Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 161:1542–1548PubMed
29.
Zurück zum Zitat Willett W, Stampfer MJ, Bain C et al. (1983) Cigarette smoking, relative weight, and menopause. Am J Epidemiol 117:651–658PubMed Willett W, Stampfer MJ, Bain C et al. (1983) Cigarette smoking, relative weight, and menopause. Am J Epidemiol 117:651–658PubMed
30.
Zurück zum Zitat Wolf AM, Hunter DJ, Colditz GA et al. (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23:991–999PubMed Wolf AM, Hunter DJ, Colditz GA et al. (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23:991–999PubMed
31.
Zurück zum Zitat Hu FB, Stampfer MJ, Rimm E et al. (1999) Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol 149:531–540PubMed Hu FB, Stampfer MJ, Rimm E et al. (1999) Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol 149:531–540PubMed
32.
Zurück zum Zitat Hu FB, Rimm E, Smith-Warner SA et al. (1999) Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr 69:243–249PubMed Hu FB, Rimm E, Smith-Warner SA et al. (1999) Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr 69:243–249PubMed
33.
Zurück zum Zitat Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr 72:912–921PubMed Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr 72:912–921PubMed
34.
Zurück zum Zitat Fung TT, Rimm EB, Spiegelman D et al. (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr 73:61–67PubMed Fung TT, Rimm EB, Spiegelman D et al. (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr 73:61–67PubMed
35.
Zurück zum Zitat Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB (2001) Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 161:1857–1862CrossRefPubMed Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB (2001) Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 161:1857–1862CrossRefPubMed
36.
Zurück zum Zitat Bentler PM (1980) Mutivariate analysis with latent variables: causal modeling. Annu Rev Psychol 31:11–21 Bentler PM (1980) Mutivariate analysis with latent variables: causal modeling. Annu Rev Psychol 31:11–21
37.
Zurück zum Zitat Joreskog KG, Sorbom D (1986) LISREL VI: analysis of linear structural relationships by maximum likelihood, instrumental variables, and least squares methods. University of Uppsala Department of Statistics, Uppsala, Sweden Joreskog KG, Sorbom D (1986) LISREL VI: analysis of linear structural relationships by maximum likelihood, instrumental variables, and least squares methods. University of Uppsala Department of Statistics, Uppsala, Sweden
38.
Zurück zum Zitat Bentler PM, Bonett DG (1980) Significance tests and goodness of fit in the analysis of covariance structures. Psychol Bull 88:588–606CrossRef Bentler PM, Bonett DG (1980) Significance tests and goodness of fit in the analysis of covariance structures. Psychol Bull 88:588–606CrossRef
39.
Zurück zum Zitat Bentler PM (1990) Comparative fit indexes in structural models. Psychometrika 107:238–246 Bentler PM (1990) Comparative fit indexes in structural models. Psychometrika 107:238–246
40.
Zurück zum Zitat Browne MW, Cudeck R (1993) Alternative ways of assessing model fit. In: Bollen KA, Long JS (eds) Testing structural equation models. Sage, Newbury Park, CA Browne MW, Cudeck R (1993) Alternative ways of assessing model fit. In: Bollen KA, Long JS (eds) Testing structural equation models. Sage, Newbury Park, CA
41.
Zurück zum Zitat Schulze MB, Hoffmann K, Kroke A, Boeing H (2003) An approach to construct simplified measures of dietary patterns from exploratory factor analysis. Br J Nutr 89:409–419 Schulze MB, Hoffmann K, Kroke A, Boeing H (2003) An approach to construct simplified measures of dietary patterns from exploratory factor analysis. Br J Nutr 89:409–419
42.
Zurück zum Zitat Comrey AL (1988) Factor-analytic methods of scale development in personality and clinical psychology. J Consult Clin Psychol 56:754–761CrossRefPubMed Comrey AL (1988) Factor-analytic methods of scale development in personality and clinical psychology. J Consult Clin Psychol 56:754–761CrossRefPubMed
43.
Zurück zum Zitat Snowdon DA, Phillips RL (1985) Does a vegetarian diet reduce the occurrence of diabetes? Am J Public Health 75:507–512PubMed Snowdon DA, Phillips RL (1985) Does a vegetarian diet reduce the occurrence of diabetes? Am J Public Health 75:507–512PubMed
45.
Zurück zum Zitat Dahlquist G (1998) The aetiology of type 1 diabetes: an epidemiological perspective. Acta Paediatr Suppl 425:5–10PubMed Dahlquist G (1998) The aetiology of type 1 diabetes: an epidemiological perspective. Acta Paediatr Suppl 425:5–10PubMed
46.
Zurück zum Zitat Ito M, Kondo Y, Nakatani A, Naruse A (1999) New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin. Biol Pharm Bull 22:988–989PubMed Ito M, Kondo Y, Nakatani A, Naruse A (1999) New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin. Biol Pharm Bull 22:988–989PubMed
47.
Zurück zum Zitat Portha B, Blondel O, Serradas P et al. (1989) The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabet Metab 15:61–75 Portha B, Blondel O, Serradas P et al. (1989) The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabet Metab 15:61–75
48.
Zurück zum Zitat Piercy V, Toseland CD, Turner NC (1998) Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. Metabolism 47:1477–1480PubMed Piercy V, Toseland CD, Turner NC (1998) Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. Metabolism 47:1477–1480PubMed
49.
Zurück zum Zitat Hofmann SM, Dong HJ, Li Z et al. (2002) Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes 51:2082–2089PubMed Hofmann SM, Dong HJ, Li Z et al. (2002) Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes 51:2082–2089PubMed
50.
Zurück zum Zitat Vlassara H, Cai W, Crandall J et al. (2002) Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 99:15596–15601CrossRefPubMed Vlassara H, Cai W, Crandall J et al. (2002) Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 99:15596–15601CrossRefPubMed
51.
Zurück zum Zitat Koschinsky T, He CJ, Mitsuhashi T et al. (1997) Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 94:6474–6479CrossRefPubMed Koschinsky T, He CJ, Mitsuhashi T et al. (1997) Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 94:6474–6479CrossRefPubMed
52.
Zurück zum Zitat Hua NW, Stoohs RA, Facchini FS (2001) Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Br J Nutr 86:515–519PubMed Hua NW, Stoohs RA, Facchini FS (2001) Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Br J Nutr 86:515–519PubMed
53.
Zurück zum Zitat Tuomainen TP, Nyyssonen K, Salonen R et al. (1997) Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care 20:426–428PubMed Tuomainen TP, Nyyssonen K, Salonen R et al. (1997) Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care 20:426–428PubMed
54.
Zurück zum Zitat Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K (1998) Relation between iron stores and non-insulin dependent diabetes in men: case-control study. BMJ 317:727PubMed Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K (1998) Relation between iron stores and non-insulin dependent diabetes in men: case-control study. BMJ 317:727PubMed
55.
Zurück zum Zitat Borel MJ, Beard JL, Farrell PA (1993) Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats. Am J Physiol 264:E380–E390PubMed Borel MJ, Beard JL, Farrell PA (1993) Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats. Am J Physiol 264:E380–E390PubMed
56.
Zurück zum Zitat Farrell PA, Beard JL, Druckenmiller M (1988) Increased insulin sensitivity in iron-deficient rats. J Nutr 118:1104–1109PubMed Farrell PA, Beard JL, Druckenmiller M (1988) Increased insulin sensitivity in iron-deficient rats. J Nutr 118:1104–1109PubMed
57.
Zurück zum Zitat Krebs M, Brehm A, Krssak M et al. (2003) Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 46:917–925 Krebs M, Brehm A, Krssak M et al. (2003) Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 46:917–925
Metadaten
Titel
Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women
verfasst von
M. B. Schulze
J. E. Manson
W. C. Willett
F. B. Hu
Publikationsdatum
01.11.2003
Verlag
Springer-Verlag
Erschienen in
Diabetologia / Ausgabe 11/2003
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-003-1220-7

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