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01.08.2007 | Article

Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity

verfasst von: H. B. Holt, S. H. Wild, N. Wareham, U. Ekelund, M. Umpleby, F. Shojaee-Moradie, R. I. G. Holt, D. I. Phillips, C. D. Byrne

Erschienen in: Diabetologia | Ausgabe 8/2007

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Abstract

Aims/hypothesis

The relative contributions of fitness (maximal oxygen uptake), physical activity energy expenditure (PAEE) and fatness to whole-body, liver and fat insulin sensitivity is uncertain. The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat.

Materials and methods

We recruited 25 men (mean [SD] age 53 [6] years). Whole-body (M value) and liver (percentage suppression of endogenous glucose output) insulin sensitivity were estimated using a hyperinsulinaemic–euglycaemic clamp. Insulin sensitivity in fat (insulin sensitivity index for NEFA) was estimated during an OGTT. Total and truncal fat were measured by dual-energy X-ray absorptiometry, fitness by treadmill, and PAEE (n = 21) by 3 day heart rate monitoring and Baecke questionnaire.

Results

In univariate analyses, fatness was strongly associated with insulin sensitivity (whole-body, liver and fat). Fitness was associated with whole-body (r = 0.53, p < 0.007) and liver (0.42, p = 0.04) insulin sensitivity, while PAEE was associated with liver insulin sensitivity (r = 0.55, p = 0.01). Regression models were established to describe associations between fatness, fitness and physical activity and measures of insulin sensitivity (whole-body, fat and liver) as outcomes. Only fatness was independently associated with whole-body insulin sensitivity (B coefficient −0.01, p = 0.001). Fitness was not associated with any outcome. Only PAEE was independently associated with liver insulin sensitivity (B coefficient 13.5, p = 0.02).

Conclusions/interpretation

Fatness explains most of the variance in whole-body insulin sensitivity. In contrast, PAEE explains most of the variance in liver insulin sensitivity.

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Titel: Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity
verfasst von: H. B. Holt
S. H. Wild
N. Wareham
U. Ekelund
M. Umpleby
F. Shojaee-Moradie
R. I. G. Holt
D. I. Phillips
C. D. Byrne
Publikationsdatum: 01.08.2007
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 8/2007
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-007-0705-1

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Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity

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