Erschienen in:
01.06.2008 | For Debate
Insulin therapy in the intensive care unit should be targeted to maintain blood glucose between 4.4 mmol/l and 6.1 mmol/l
verfasst von:
G. Van den Berghe
Erschienen in:
Diabetologia
|
Ausgabe 6/2008
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Excerpt
Hyperglycaemia has been repeatedly associated with risk of mortality and morbidity in the intensive care unit (ICU). However, establishing a causal relationship between hyperglycaemia and adverse outcome requires randomised controlled trials assessing the impact of treating/preventing hyperglycaemia in this condition. The only two randomised controlled studies that have addressed this question so far targeted normoglycaemia (4.4–6.1 mmol/l) in ICUs and showed that the link indeed appears causal. The evidence currently available is thus in favour of a ‘normal ≤6.1 mmol/l’ level for blood glucose control in ICUs and is not supportive of J. Miles’s viewpoint in this debate [
1], as studies on any other level have not been performed. …