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Diabetologia

Erschienen in:

01.04.2014 | Article

Working-age adults with diabetes experience greater susceptibility to seasonal influenza: a population-based cohort study

verfasst von: Darren Lau, Dean T. Eurich, Sumit R. Majumdar, Alan Katz, Jeffrey A. Johnson

Erschienen in: Diabetologia | Ausgabe 4/2014

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Abstract

Aims/hypothesis

The aim of this work was to compare the incidence of illness attributable to influenza in working-age adults (age <65 years) with and without diabetes.

Methods

We performed a cohort study using administrative data from Manitoba, Canada, between 2000 and 2008. All working-age adults with diabetes were identified and matched with up to two non-diabetic controls. We analysed the rates of influenza-like illness physician visits and hospitalisations, pneumonia and influenza hospitalisations, and all-cause hospitalisations. Multivariable regressions were used to estimate the influenza-attributable rate of each outcome.

Results

We included 745,777 person-years of follow-up among 166,715 subjects. The median age was 50–51 years and 48–49% were women; adults with diabetes had more comorbidities and were more likely to be vaccinated for influenza than those without diabetes. Compared with similar adults without diabetes, those with diabetes had a 6% greater (RR 1.06, 95% CI 1.02, 1.10; absolute risk difference 6 per 1,000 adults per year) increase in all-cause hospitalisations associated with influenza, representing a total of 54 additional hospitalisations. There were no differences in the influenza-attributable rates of influenza-like illness (p = 0.06) or pneumonia and influenza (p = 0.11).

Conclusions/interpretation

Guidelines calling for influenza vaccinations in diabetic, in addition to elderly, adults implicitly single out working-age adults with diabetes. The evidence supporting such guidelines has hitherto been scant. We found that working-age adults with diabetes appear more susceptible to serious influenza-attributable illness. These findings represent the strongest available evidence for targeting diabetes as an indication for influenza vaccination, irrespective of age.

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Titel: Working-age adults with diabetes experience greater susceptibility to seasonal influenza: a population-based cohort study
verfasst von: Darren Lau
Dean T. Eurich
Sumit R. Majumdar
Alan Katz
Jeffrey A. Johnson
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 4/2014
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-013-3158-8

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Working-age adults with diabetes experience greater susceptibility to seasonal influenza: a population-based cohort study

Abstract

Aims/hypothesis

Methods

Results

Conclusions/interpretation

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Aims/hypothesis

Methods

Results

Conclusions/interpretation

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