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Erschienen in: Diabetologia 6/2015

01.06.2015 | Article

Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study

verfasst von: Wei Bao, Edwina Yeung, Deirdre K. Tobias, Frank B. Hu, Allan A. Vaag, Jorge E. Chavarro, James L. Mills, Louise G. Grunnet, Katherine Bowers, Sylvia H. Ley, Michele Kiely, Sjurdur F. Olsen, Cuilin Zhang

Erschienen in: Diabetologia | Ausgabe 6/2015

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Abstract

Aims/hypothesis

Women with a history of gestational diabetes mellitus (GDM) are advised to control their weight after pregnancy. We aimed to examine how adiposity and weight change influence the long-term risk of developing type 2 diabetes after GDM.

Methods

We included 1,695 women who had incident GDM between 1991 and 2001, as part of the Diabetes & Women’s Health study, and followed them until the return of the 2009 questionnaire. Body weight and incident type 2 diabetic cases were reported biennially. We defined baseline as the questionnaire period when women reported an incident GDM pregnancy. We estimated HRs and 95% CIs using Cox proportional hazards models.

Results

We documented 259 incident cases of type 2 diabetes during up to 18 years of follow-up. The adjusted HRs of type 2 diabetes associated with each 1 kg/m2 increase in BMI were 1.16 (95% CI 1.12, 1.19) for baseline BMI and 1.16 (95% CI 1.13, 1.20) for most recent BMI. Moreover, each 5 kg increment of weight gain after GDM development was associated with a 27% higher risk of type 2 diabetes (adjusted HR 1.27; 95% CI 1.04, 1.54). Jointly, women who had a BMI ≥30.0 kg/m2 at baseline and gained ≥5 kg after GDM had an adjusted HR of 43.19 (95% CI 13.60, 137.11), compared with women who had a BMI <25.0 kg/m2 at baseline and gained <5 kg after GDM.

Conclusions/interpretation

Baseline BMI, most recent BMI and weight gain after GDM were significantly and positively associated with risk of progression from GDM to type 2 diabetes.
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Metadaten
Titel
Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study
verfasst von
Wei Bao
Edwina Yeung
Deirdre K. Tobias
Frank B. Hu
Allan A. Vaag
Jorge E. Chavarro
James L. Mills
Louise G. Grunnet
Katherine Bowers
Sylvia H. Ley
Michele Kiely
Sjurdur F. Olsen
Cuilin Zhang
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Diabetologia / Ausgabe 6/2015
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-015-3537-4

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