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Erschienen in:
01.07.2015 | Article
Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study
Erschienen in: Diabetologia | Ausgabe 7/2015
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Aims/hypothesis
The aim of this work was to analyse the rates of incidence and remission of type 2 diabetes in relation to baseline BMI and weight change in the prospective, controlled Swedish Obese Subjects (SOS) study.
Methods
Three-thousand four-hundred and eighty-five obese individuals receiving bariatric surgery or conventional treatment were grouped into four baseline BMI categories (<35, 35–40, 40–45 or ≥45 kg/m2) and five weight-change categories according to their BMI at 2 years (increase [≥1 BMI unit increase], no change [less than 1 BMI unit change], minor reduction [−1 to −9 BMI units], medium reduction [−10 to −14 BMI units] and major reduction [< −15 BMI units]). The incidence and remission of diabetes at 2 years was assessed.
Results
Among individuals with no weight change, diabetes incidence rates were 5.5%, 7.4%, 8.3% and 5.2%, in the four baseline BMI categories, respectively. In those with an initial BMI of 35–40, 40–45 and ≥45 kg/m2 who attained a minor reduction in weight, the corresponding rates were 1.3%, 1.2% and 3.4%, respectively. In both the medium- and major-weight-reduction groups, diabetes incidence was ≤0.5%. Among individuals with diabetes at baseline, the remission rates were 15.3–26.9% in the no-weight-change groups, and 48.1–70% for individuals who attained a minor weight reduction. In the medium- and major-weight-reduction groups, the remission rate was 77–97%. There were no differences in 2 year incidence and remission rates between different baseline BMI groups that achieved the same degree of weight reduction.
Conclusions/interpretation
In obese individuals, the favourable effect of weight reduction on type 2 diabetes incidence and remission is independent of initial BMI.
Trial registration ClinicalTrials.gov number NCT01479452