Introduction
Glycaemic memories and vascular complications of diabetes
Substrate | Target | Modification | Relationship to transcription | Writer |
---|---|---|---|---|
DNA | CpG | Cytosine methylation | Repressive/activating | DNMT1, DNMT3a, DNMT3b |
H3 histone | H3R2 | Arginine methylation | Repressive | PRMT6, CARM1 |
H3K4 | Lysine methylation | Activating | KMT2A-E, SET7, SETD3, SETMAR, SETD1A, SETD1B, NSD3, SMYD1, SMYD2, SMYD3 | |
H3R8 | Arginine methylation | Repressive | PRMT5 | |
H3K9 | Lysine acetylation | Activating | ELP3, KAT2A | |
H3K14 | Lysine methylation | Repressive | KAT2A, EHMT2, EZH2, SETDB1, SETDB2, SUV39H1, SUV39H2 | |
Lysine acetylation | Activating | CLOCK, KAT6A, KAT2A, MGEA5, KAT2B, KAT5 | ||
H3R17 | Arginine methylation | Activating | CARM1 | |
H3K18 | Lysine acetylation | Activating | CREBBP, ELP3, EP300 | |
H3K23 | Lysine acetylation | Activating | KAT2A, EP300 | |
H3R26 | Arginine methylation | Activating | CARM1 | |
H3K27 | Lysine acetylation | Activating | CREBBP, EP300 | |
Lysine methylation | Repressive | EZH1, EZH2, SETDB1, SETDB2, SUV39H1, SUV39H2, EHMT2, NSD3 | ||
H3K36 | Lysine methylation | Activating | SETD2, SETD3, SMYD2, SETMAR, NSD2 | |
H3K79 | Lysine methylation | Activating | DOT1L | |
H4 histone | H4R3 | Lysine methylation | Repressive/activating | PRMT1, PRMT7 |
H4K5 | Lysine acetylation | Activating | CREBBP, KAT2A, KAT5, KAT7, EP300 | |
H4K8 | Lysine acetylation | Activating | KAT5, CREBBP, KAT2A, EP300, KAT7 | |
H4K12 | Lysine acetylation | Activating | CREBBP, KAT2A, KAT5, EP300, KAT7 | |
H4K16 | Lysine acetylation | Activating | CREBBP, KAT2A, EP300 | |
H4K20 | Lysine methylation | Repressive | KMT5B, KMT5C, SET8 |