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Diabetologia

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15.08.2018 | Review

Biomarkers of islet beta cell stress and death in type 1 diabetes

verfasst von: Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira

Erschienen in: Diabetologia | Ausgabe 11/2018

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Abstract

Recent work on the pathogenesis of type 1 diabetes has led to an evolving recognition of the heterogeneity of this disease, both with regards to clinical phenotype and responses to therapies to prevent or revert diabetes. This heterogeneity not only limits efforts to accurately predict clinical disease but also is reflected in differing responses to immunomodulatory therapeutics. Thus, there is a need for robust biomarkers of beta cell health, which could provide insight into pathophysiological differences in disease course, improve disease prediction, increase the understanding of therapeutic responses to immunomodulatory interventions and identify individuals most likely to benefit from these therapies. In this review, we outline current literature, limitations and future directions for promising circulating markers of beta cell stress and death in type 1 diabetes, including markers indicating abnormal prohormone processing, circulating RNAs and circulating DNAs.

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Titel: Biomarkers of islet beta cell stress and death in type 1 diabetes
verfasst von: Emily K. Sims
Carmella Evans-Molina
Sarah A. Tersey
Decio L. Eizirik
Raghavendra G. Mirmira
Publikationsdatum: 15.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 11/2018
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-018-4712-1

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