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Die Orthopädie

Erschienen in:

04.10.2017 | Leitthema

Aktuelle Übersicht knorpelregenerativer Verfahren

verfasst von: H. Schenker, M. Wild, B. Rath, M. Tingart, A. Driessen, V. Quack, PD Dr. M. Betsch

Erschienen in: Die Orthopädie | Ausgabe 11/2017

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Zusammenfassung

Hintergrund

Bei Knorpelgewebe handelt es sich um ein avaskuläres, alymphatisches und nicht innerviertes Gewebe mit einem geringen intrinsischen Reparationspotenzial. Aufgrund der hohen Prävalenz und der klinischen Bedeutung von Knorpelschäden stellen diese bis heute eine Herausforderung für die behandelnden Ärzte dar.

Ziel

Der vorliegende Artikel soll den Lesern einen Überblick über die aktuell verfügbaren Knorpeldefekttherapien geben und über ihre Ergebnisse informieren.

Methoden

Die Mikrofrakturierung stellt bis heute den Goldstandard in der Behandlung von kleinen Knorpeldefekten dar. Zur Therapie von umschriebenen, kleinen osteochondralen Defekten kann das osteochondrale autologe Transplantationssystem (OATS) eingesetzt werden. Größere Defekte lassen sich erfolgreich mit der autologen matrixinduzierten Chondrogenese (AMIC) behandeln oder mit der matrixassoziierten autologen Chondrozytentransplantation (MACT).

Zusammenfassung

Trotz bestehender Limitationen der aktuellen Knorpeldefekttherapien kann durch diese eine kurz- bis mittelfristige Verbesserung des Beschwerdebildes bei Patienten mit lokalen Knorpelschäden erreicht werden. Weitere Entwicklungen und Studien sind notwendig, um langfristig gute Ergebnisse nach einer Knorpeltherapie zu erreichen.

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Titel: Aktuelle Übersicht knorpelregenerativer Verfahren
verfasst von: H. Schenker
M. Wild
B. Rath
M. Tingart
A. Driessen
V. Quack
PD Dr. M. Betsch
Publikationsdatum: 04.10.2017
Verlag: Springer Medizin
Erschienen in: Die Orthopädie / Ausgabe 11/2017
Print ISSN: 2731-7145
Elektronische ISSN: 2731-7153
DOI: https://doi.org/10.1007/s00132-017-3474-7

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