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Erschienen in: Intensive Care Medicine 8/2003

01.08.2003 | Original

Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis

verfasst von: Christophe Faisy, Emmanuel Guerot, Jean-Luc Diehl, Eléonore Iftimovici, Jean-Yves Fagon

Erschienen in: Intensive Care Medicine | Ausgabe 8/2003

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Abstract

Objective

To compare the rates of clinically significant gastrointestinal bleeding and the number of blood units and endoscopies required for gastrointestinal hemorrhage between patients receiving or not receiving stress-ulcer prophylaxis.

Design

Historical observational study comparing two consecutive periods: with (phase 1) and without stress-ulcer prophylaxis (phase 2).

Design and setting

A 17-bed intensive care unit in a university teaching hospital.

Patients

In phase 1 there were 736 patients and in phase 2 737. Those in the two phases were comparable in age and reason for admission; clinically significant gastrointestinal bleeding rates did not differ between the two phases, but patients in phase 2 were more severely ill.

Measurements and results

Comparable numbers of blood units were transfused per bleeding patient in the two phases, especially for patients with significant gastrointestinal bleeding. During each phase 19 fibroscopies were performed for significant bleeding, and two patients required surgery. The clinically significant gastrointestinal bleeding rate and outcome did not differ in patients with at least one risk factor. Total expenditures directly related to gastrointestinal bleeding were similar during the two phases; the total cost incurred by stress-ulcer prophylaxis was estimated at €6700.

Conclusions

Our results suggest that stress-ulcer prophylaxis does not influence the clinically significant gastrointestinal bleeding rate in intensive care unit patients or the cost of its management.
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Metadaten
Titel
Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis
verfasst von
Christophe Faisy
Emmanuel Guerot
Jean-Luc Diehl
Eléonore Iftimovici
Jean-Yves Fagon
Publikationsdatum
01.08.2003
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 8/2003
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-1863-3

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