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Erschienen in: Intensive Care Medicine 3/2004

01.03.2004 | Original

Comparison of three severity scores for critically ill cancer patients

verfasst von: Peter Schellongowski, Michael Benesch, Thomas Lang, Friederike Traunmüller, Christian Zauner, Klaus Laczika, Gottfried J. Locker, Michael Frass, Thomas Staudinger

Erschienen in: Intensive Care Medicine | Ausgabe 3/2004

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Abstract

Objective

To compare three scoring systems, the Acute Physiology and Chronic Health Evaluation (APACHE) II, the Simplified Acute Physiology Score (SAPS) II and a modified Mortality Probability Model II (ICU cancer mortality model, ICMM) for their prognostic value for mortality during hospital stay in a group of cancer patients admitted to a medical ICU.

Design

Prospective cohort study.

Setting

Medical ICU of a tertiary care hospital.

Patients

Two hundred forty-two consecutive cancer patients admitted to the ICU.

Measurements and results

Variables included in APACHE II, SAPS II and the ICMM scores as well as demographic data were assessed during the first 24 h of stay in the ICU. Hospital mortality was measured; it was 44%. Calibration for all three scoring systems was acceptable, SAPS II yielded a significantly superior discrimination between survivors and non-survivors. The areas under the receiver operating characteristic curves were 0.776 for APACHE II, 0.825 for SAPS II and 0.698 for the ICMM.

Conclusion

The SAPS II was superior to APACHE II and ICMM. The newly developed ICMM does not improve mortality prediction in critically ill cancer patients.
Literatur
1.
Zurück zum Zitat Sculier JP, Markiewicz E (1991) Medical cancer patients and intensive care. Anticancer Res 11:2171–2174PubMed Sculier JP, Markiewicz E (1991) Medical cancer patients and intensive care. Anticancer Res 11:2171–2174PubMed
2.
Zurück zum Zitat Baumann WR, Jung RC, Koss M, Boylen CT, Navarro L, Sharma OP (1986) Incidence and mortality of adult respiratory distress syndrome: a prospective analysis from a metropolitan hospital. Crit Care Med 14:1–4PubMed Baumann WR, Jung RC, Koss M, Boylen CT, Navarro L, Sharma OP (1986) Incidence and mortality of adult respiratory distress syndrome: a prospective analysis from a metropolitan hospital. Crit Care Med 14:1–4PubMed
3.
Zurück zum Zitat Sussman NL, Lake JR (1996) Treatment of hepatic failure 1996: current concepts and progress toward liver dialysis. Am J Kidney Dis 27:605–621PubMed Sussman NL, Lake JR (1996) Treatment of hepatic failure 1996: current concepts and progress toward liver dialysis. Am J Kidney Dis 27:605–621PubMed
4.
Zurück zum Zitat Krafft P, Fridrich P, Pernerstorfer T, Fitzgerald RD, Koc D, Schneider B, Hammerle AF, Steltzer H (1996) The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations. Intensive Care Med 22:519–529PubMed Krafft P, Fridrich P, Pernerstorfer T, Fitzgerald RD, Koc D, Schneider B, Hammerle AF, Steltzer H (1996) The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations. Intensive Care Med 22:519–529PubMed
5.
Zurück zum Zitat Marik PE, Craft M (1997) An outcomes analysis of in-hospital cardiopulmonary resuscitation: the futility rationale for do not resuscitate orders. J Crit Care 12:142–146PubMed Marik PE, Craft M (1997) An outcomes analysis of in-hospital cardiopulmonary resuscitation: the futility rationale for do not resuscitate orders. J Crit Care 12:142–146PubMed
6.
Zurück zum Zitat The British Thoracic Society Research Committee and The Public Health Laboratory Service (1992) The aetiology, management and outcome of severe community-acquired pneumonia on the intensive care unit. Respir Med 86:7–13PubMed The British Thoracic Society Research Committee and The Public Health Laboratory Service (1992) The aetiology, management and outcome of severe community-acquired pneumonia on the intensive care unit. Respir Med 86:7–13PubMed
7.
Zurück zum Zitat Massion PB, Dive AM, Doyen C, Bulpa P, Jamart J, Bosly A, Installe E (2002) Prognosis of hematologic malignancies does not predict intensive care mortality. Crit Care Med 30:2260–2270PubMed Massion PB, Dive AM, Doyen C, Bulpa P, Jamart J, Bosly A, Installe E (2002) Prognosis of hematologic malignancies does not predict intensive care mortality. Crit Care Med 30:2260–2270PubMed
8.
Zurück zum Zitat Sculier JP, Paesmans M, Markiewicz E, Berghmans T (2000) Scoring systems in cancer patients admitted for an acute complication in a medical intensive care unit. Crit Care Med 28:2786–2792PubMed Sculier JP, Paesmans M, Markiewicz E, Berghmans T (2000) Scoring systems in cancer patients admitted for an acute complication in a medical intensive care unit. Crit Care Med 28:2786–2792PubMed
9.
Zurück zum Zitat Staudinger T, Stoiser B, Mullner M, Locker GJ, Laczika K, Knapp S, Burgmann H, Wilfing A, Kofler J, Thalhammer F, Frass M (2000) Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit. Crit Care Med 28:1322–1328PubMed Staudinger T, Stoiser B, Mullner M, Locker GJ, Laczika K, Knapp S, Burgmann H, Wilfing A, Kofler J, Thalhammer F, Frass M (2000) Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit. Crit Care Med 28:1322–1328PubMed
10.
Zurück zum Zitat Groeger JS, Lemeshow S, Price K, Nierman DM, White P Jr, Klar J, Granovsky S, Horak D, Kish SK (1998) Multicenter outcome study of cancer patients admitted to the intensive care unit: a probability mortality model. J Clin Oncol 16:761–770PubMed Groeger JS, Lemeshow S, Price K, Nierman DM, White P Jr, Klar J, Granovsky S, Horak D, Kish SK (1998) Multicenter outcome study of cancer patients admitted to the intensive care unit: a probability mortality model. J Clin Oncol 16:761–770PubMed
11.
Zurück zum Zitat Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, Bastos PG, Sirio CA, Murphy DJ, Lotring T, Damiano A (1991) The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100:1619–1636PubMed Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, Bastos PG, Sirio CA, Murphy DJ, Lotring T, Damiano A (1991) The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100:1619–1636PubMed
12.
Zurück zum Zitat Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2964PubMed Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2964PubMed
13.
Zurück zum Zitat Lemeshow S, Hosmer DW Jr (1982) A review of goodness-of-fit statistics for use in the development of logistic regression models. Am J Epidemiol 115:92–106PubMed Lemeshow S, Hosmer DW Jr (1982) A review of goodness-of-fit statistics for use in the development of logistic regression models. Am J Epidemiol 115:92–106PubMed
14.
Zurück zum Zitat Weinstein MC, Fineberg HV (1980) Clinical decision analysis. Saunders, Philadelphia Weinstein MC, Fineberg HV (1980) Clinical decision analysis. Saunders, Philadelphia
15.
Zurück zum Zitat DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMed DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMed
16.
Zurück zum Zitat Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39:561–577PubMed Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39:561–577PubMed
17.
Zurück zum Zitat Rosenberg AL (2002) Recent innovations in intensive care unit risk-prediction models. Curr Opin Crit Care 8:321–330CrossRefPubMed Rosenberg AL (2002) Recent innovations in intensive care unit risk-prediction models. Curr Opin Crit Care 8:321–330CrossRefPubMed
18.
Zurück zum Zitat Patel PA, Grant BJB (1999) Application of mortality prediction systems to individual intensive care units. Intensive Care Med 25:977–982PubMed Patel PA, Grant BJB (1999) Application of mortality prediction systems to individual intensive care units. Intensive Care Med 25:977–982PubMed
19.
Zurück zum Zitat Carson SS, Bach PB (2001) Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measures. Chest 120:928–933CrossRefPubMed Carson SS, Bach PB (2001) Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measures. Chest 120:928–933CrossRefPubMed
20.
Zurück zum Zitat Reina A, Vazquez G, Aguayo E, Bravo I, Colmenero M, Bravo M (1997) Mortality discrimination in acute myocardial infarction: comparison between APACHE III and SAPS II prognosis systems. Intensive Care Med 23:326–330CrossRefPubMed Reina A, Vazquez G, Aguayo E, Bravo I, Colmenero M, Bravo M (1997) Mortality discrimination in acute myocardial infarction: comparison between APACHE III and SAPS II prognosis systems. Intensive Care Med 23:326–330CrossRefPubMed
21.
Zurück zum Zitat Bein T, Frohlich D, Pomsl J, Forst H, Pratschke E (1995) The predictive value of four scoring systems in liver transplant recipients. Intensive Care Med 21:32–37PubMed Bein T, Frohlich D, Pomsl J, Forst H, Pratschke E (1995) The predictive value of four scoring systems in liver transplant recipients. Intensive Care Med 21:32–37PubMed
22.
Zurück zum Zitat Fiaccadori E, Maggiore U, Lombardi M, Leonardi S, Rotelli C, Borghetti A (2000) Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems. Kidney Int 58:283–292PubMed Fiaccadori E, Maggiore U, Lombardi M, Leonardi S, Rotelli C, Borghetti A (2000) Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems. Kidney Int 58:283–292PubMed
23.
Zurück zum Zitat Guiguet M, Blot F, Escudier B, Antoun S, Leclercq B, Nitenberg G (1998) Severity of illness scores for neutropenic patients in an intensive care unit: which is the best predictor? Do multiple assessment times improve the predictive value? Crit Care Med 26:488–493 Guiguet M, Blot F, Escudier B, Antoun S, Leclercq B, Nitenberg G (1998) Severity of illness scores for neutropenic patients in an intensive care unit: which is the best predictor? Do multiple assessment times improve the predictive value? Crit Care Med 26:488–493
24.
Zurück zum Zitat Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U (2002) Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med 28:1294–1300CrossRef Kroschinsky F, Weise M, Illmer T, Haenel M, Bornhaeuser M, Hoeffken G, Ehninger G, Schuler U (2002) Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med 28:1294–1300CrossRef
25.
Zurück zum Zitat Groeger JS, White P, Nierman DM, Glassmann J, Shi W, Horak D, Price K (1999) Outcome of cancer patients requiring mechanical ventilation. J Clin Oncol 17:991–997PubMed Groeger JS, White P, Nierman DM, Glassmann J, Shi W, Horak D, Price K (1999) Outcome of cancer patients requiring mechanical ventilation. J Clin Oncol 17:991–997PubMed
26.
Zurück zum Zitat Lemeshow S, Le Gall JR (1994) Modeling the severity of illness of ICU patients. A systems update. JAMA 272:1049–1055PubMed Lemeshow S, Le Gall JR (1994) Modeling the severity of illness of ICU patients. A systems update. JAMA 272:1049–1055PubMed
27.
Zurück zum Zitat Ferrand E, Robert R, Ingrand P, Lemaire F (2001) Withholding and withdrawal of life support in intensive-care units in France: a prospective survey. Lancet 357:9–14PubMed Ferrand E, Robert R, Ingrand P, Lemaire F (2001) Withholding and withdrawal of life support in intensive-care units in France: a prospective survey. Lancet 357:9–14PubMed
28.
Zurück zum Zitat Schapira DV, Studnicki J, Bradham DD, Wolff P, Jarrett A (1993) Intensive care, survival and expense of treating critically ill cancer patients. JAMA 269:783–786PubMed Schapira DV, Studnicki J, Bradham DD, Wolff P, Jarrett A (1993) Intensive care, survival and expense of treating critically ill cancer patients. JAMA 269:783–786PubMed
29.
Zurück zum Zitat Brunet F, Lanore JJ, Dhainaut JF, Dreyfus F, Vaxelaire JF, Nouira S, Giraud T, Armaganidis A, Monsallier JF (1990) Is intensive care justified for patients with haematological malignancies? Intensive Care Med 16:291–297PubMed Brunet F, Lanore JJ, Dhainaut JF, Dreyfus F, Vaxelaire JF, Nouira S, Giraud T, Armaganidis A, Monsallier JF (1990) Is intensive care justified for patients with haematological malignancies? Intensive Care Med 16:291–297PubMed
30.
Zurück zum Zitat Azoulay E, Moreau D, Alberti C, Leleu G, Adrie C, Barboteu M, Cottu P, Levy V, Le Gall JR, Schlemmer B (2000) Predictors of short-term mortality in critically ill patients with solid malignancies. Intensive Care Med 26:1817–1823CrossRefPubMed Azoulay E, Moreau D, Alberti C, Leleu G, Adrie C, Barboteu M, Cottu P, Levy V, Le Gall JR, Schlemmer B (2000) Predictors of short-term mortality in critically ill patients with solid malignancies. Intensive Care Med 26:1817–1823CrossRefPubMed
31.
Zurück zum Zitat Faber-Langendoen K, Caplan AL, McGlave PB (1993) Survival of adult bone marrow transplant patients receiving mechanical ventilation: a case for restricted use. Bone Marrow Transplant 12:501–507PubMed Faber-Langendoen K, Caplan AL, McGlave PB (1993) Survival of adult bone marrow transplant patients receiving mechanical ventilation: a case for restricted use. Bone Marrow Transplant 12:501–507PubMed
32.
Zurück zum Zitat Crawford SW (1998) Using outcome research to improve the management of blood and marrow transplant recipients in the intensive care unit. New Horiz 6:69–74PubMed Crawford SW (1998) Using outcome research to improve the management of blood and marrow transplant recipients in the intensive care unit. New Horiz 6:69–74PubMed
33.
Zurück zum Zitat Khassawneh BY, White P, Anaissie EJ, Barlogie B, Hiller FC (2002) Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantation. Chest 121:185–188CrossRefPubMed Khassawneh BY, White P, Anaissie EJ, Barlogie B, Hiller FC (2002) Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantation. Chest 121:185–188CrossRefPubMed
34.
Zurück zum Zitat Epner DE, White P, Krasnoff M, Khanduja S, Kimball KT, Knaus WA (1996) Outcome of mechanical ventilation for adults with hematologic malignancy. J Investig Med 44:254–260PubMed Epner DE, White P, Krasnoff M, Khanduja S, Kimball KT, Knaus WA (1996) Outcome of mechanical ventilation for adults with hematologic malignancy. J Investig Med 44:254–260PubMed
35.
Zurück zum Zitat Shaw A, Weavind L, Feeley T (2001) Mechanical ventilation in critically ill cancer patients. Curr Opin Oncol 13:224–228CrossRefPubMed Shaw A, Weavind L, Feeley T (2001) Mechanical ventilation in critically ill cancer patients. Curr Opin Oncol 13:224–228CrossRefPubMed
36.
Zurück zum Zitat Kongsgaard UE, Meidell NK (1999) Mechanical ventilation in critically ill cancer patients: outcome and utilisation of resources. Support Care Cancer 7:95–99CrossRef Kongsgaard UE, Meidell NK (1999) Mechanical ventilation in critically ill cancer patients: outcome and utilisation of resources. Support Care Cancer 7:95–99CrossRef
Metadaten
Titel
Comparison of three severity scores for critically ill cancer patients
verfasst von
Peter Schellongowski
Michael Benesch
Thomas Lang
Friederike Traunmüller
Christian Zauner
Klaus Laczika
Gottfried J. Locker
Michael Frass
Thomas Staudinger
Publikationsdatum
01.03.2004
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 3/2004
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-2043-1

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