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01.06.2004 | Experimental

Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome

verfasst von: Francesco Imperatore, Salvatore Cuzzocrea, Carlo Luongo, Giovanni Liguori, Antonella Scafuro, Antonella De Angelis, Francesco Rossi, Achille P. Caputi, Amelia Filippelli

Erschienen in: Intensive Care Medicine | Ausgabe 6/2004

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Abstract

Objective

This study investigated the effects of hyperbaric oxygen (HBO) therapy on the cardiovascular alteration (e.g. mean arterial pressure, vascular reactivity of thoracic aorta rings changes) caused by zymosan in rats.

Design

Rats.

Setting

University research laboratory.

Intervention and measurements

We investigated the effects of HBO therapy (2 ATA at the fourth and eleventh hours after study onset) on the cardiovascular alteration caused by zymosan (500 mg/kg, administered i.p. as a suspension in saline) in rats. Cardiovascular alterations were assessed 18 h after administration of zymosan and/or HBO therapy.

Results

Treatment of rats with HBO therapy attenuated the vasoplegic response to zymosan. In fact, the analysis of arterial pressure curves revealed no signs of vasoplegic shock. The aorta rings of animals treated with zymosan and HBO had a significantly increased contraction to norepinephrine (NE) and endothelin-1 (ET-1) and dilation to acetylcholine (ACh) compared with the zymosan group. The HBO therapy also attenuated the increase of malondialdehyde (MDA) levels caused by zymosan in the aorta. Immunohistochemical analysis for nitrotyrosine and for iNOS revealed positive staining in the aorta from zymosan-treated rats. The degree of staining for nitrotyrosine and iNOS was markedly reduced in tissue sections obtained from zymosan-rats treated with HBO therapy.

Conclusion

This study provides the first evidence that HBO therapy attenuates the degree of zymosan-induced cardiovascular derangement in the rat.

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Titel: Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome
verfasst von: Francesco Imperatore
Salvatore Cuzzocrea
Carlo Luongo
Giovanni Liguori
Antonella Scafuro
Antonella De Angelis
Francesco Rossi
Achille P. Caputi
Amelia Filippelli
Publikationsdatum: 01.06.2004
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 6/2004
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-2138-8

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