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Intensive Care Medicine

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01.03.2004 | Experimental

Dynamic elastic pressure-volume loops in healthy pigs recorded with inspiratory and expiratory sinusoidal flow modulation

Relationship to static pressure-volume loops

verfasst von: Ulrika Bitzén, Björn Drefeldt, Lisbet Niklason, Björn Jonson

Erschienen in: Intensive Care Medicine | Ausgabe 3/2004

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Abstract

Objective

The objective was to analyse relationships between inspiratory and expiratory static and dynamic elastic pressure-volume (P_el/V) curves in healthy pigs.

Design

The modulated low flow method was developed to allow studies also of the expiratory P_el/V curves. Static P_el/V (P_el,st/V) and dynamic P_el/V (P_el,dyn/V) loops were studied in healthy pigs.

Setting

Animal research laboratory in a university hospital.

Material

Ten healthy anaesthetised and paralysed pigs.

Interventions and measurements

A computer controlled a Servo Ventilator 900C with respect to respiratory rate, inspiratory flow and expiratory pressure to achieve a sinusoidal modulation of inspiration and expiration for determination of P_el,dyn/V loops from zero end-expiratory pressure (ZEEP) and from a positive end-expiratory pressure (PEEP) of 6 cmH₂O to 20, 35 and 50 cmH₂O. The same system was used for studies of P_el,st/V loops with the flow-interruption method from ZEEP and PEEP to 35 cmH₂O. Recordings were analysed with an iterative technique.

Results

The feasibility of automated determination of P_el,dyn/V loops was demonstrated. Differences between P_el,dyn/V and P_el,st/V loops were explained by viscoelastic behaviour. P_el,st/V loops recorded from PEEP to 35 cmH₂O showed no significant hysteresis, indicating a non-significant surface tension hysteresis. P_el,dyn/V loops from PEEP and both P_el,st/V and P_el,dyn/V loops from ZEEP to 35 cmH₂O showed hysteresis. This indicates that lung collapse/re-expansion caused P_el/V loop hysteresis which, in P_el,dyn/V loops, was augmented by viscoelastic behaviour.

Conclusions

Viscoelasticity influences P_el,dyn/V curves. Hysteresis caused by surface tension merits re-evaluation. Lung collapse and re-expansion may be indicated by hysteresis of P_el/V loops.

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Titel: Dynamic elastic pressure-volume loops in healthy pigs recorded with inspiratory and expiratory sinusoidal flow modulation
Relationship to static pressure-volume loops
verfasst von: Ulrika Bitzén
Björn Drefeldt
Lisbet Niklason
Björn Jonson
Publikationsdatum: 01.03.2004
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 3/2004
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-2156-6

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Dynamic elastic pressure-volume loops in healthy pigs recorded with inspiratory and expiratory sinusoidal flow modulation

Relationship to static pressure-volume loops

Abstract

Objective

Design

Setting

Material

Interventions and measurements

Results

Conclusions

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Abstract

Objective

Design

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Results

Conclusions

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