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Intensive Care Medicine

Erschienen in:

01.05.2004 | Review

Stress-hyperglycemia, insulin and immunomodulation in sepsis

verfasst von: Paul E. Marik, Murugan Raghavan

Erschienen in: Intensive Care Medicine | Ausgabe 5/2004

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Abstract

Stress-hyperglycemia and insulin resistance are exceedingly common in critically ill patients, particularly those with sepsis. Multiple pathogenetic mechanisms are responsible for this metabolic syndrome; however, increased release of pro-inflammatory mediators and counter-regulatory hormones may play a pivotal role. Recent data suggests that hyperglycemia may potentiate the pro-inflammatory response while insulin has the opposite effect. Furthermore, emerging evidence suggests that tight glycemic control will improve the outcome of critically ill patients. This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder.

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Titel: Stress-hyperglycemia, insulin and immunomodulation in sepsis
verfasst von: Paul E. Marik
Murugan Raghavan
Publikationsdatum: 01.05.2004
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 5/2004
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2167-y

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