Erschienen in:
01.05.2004 | Brief Report
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
verfasst von:
Pierre Delanaye, Bernard Lambermont, Jean-Paul Chapelle, Jacques Gielen, Paul Gerard, Georges Rorive
Erschienen in:
Intensive Care Medicine
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Ausgabe 5/2004
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Abstract
Objective
To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.
Design
Prospective observational study.
Setting
Medical intensive care unit at a university hospital.
Patients and participants
Fourteen patients hospitalised in a medical intensive care unit.
Interventions
Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.
Measurements and results
Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m2 was significantly better than that of creatinine (p<0.05).
Conclusions
Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.