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01.04.2005 | Original

Clinical outcome of immunonutrition in a heterogeneous intensive care population

verfasst von: Hans Kieft, Arnout N. Roos, Jenneke D. E. van Drunen, Alexander J. G. H. Bindels, Jacques G. Bindels, Zandrie Hofman

Erschienen in: Intensive Care Medicine | Ausgabe 4/2005

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Abstract

Objective

To study the effect of a high-protein enteral formula enriched with arginine, glutamine, and antioxidants and containing ω3 fatty acids and a mixture of fibers, on the clinical outcome of a heterogeneous intensive care (ICU) population.

Design and setting

A randomized, prospective, double blind, controlled, two-center clinical trial in two intensive care units in The Netherlands.

Patients and participants

A total of 597 adult ICU patients expected to require enteral tube feeding for more than 2 days were randomized to receive immunonutrition or an isocaloric control formula.

Interventions

Patients received either the immunonutrition or the control feed.

Measurements and results

Intention-to-treat and per-protocol analyses showed no statistically significant difference in clinical outcome parameters between the two groups. Results of the intention-to-treat analysis in control vs. immunonutrition were: median ICU length of stay in days, 8.0 (IQR 5.0–16.0) vs. 7.0 (4.0–14.0); median hospital length of stay in days, 20.0 (IQR 10.0–34.0) vs. 20.0 (10.0–35.0); median days of ventilation, 6.0 (IQR 3.0–12.0) vs. 6.0 (IQR 3.0–12.0); ICU mortality, 26.8% vs. 28.2%; in-hospital mortality, 36.4% vs. 38.5%; infectious complications, 41.7% vs. 43.0%

Conclusions

The results of this largest randomized, controlled trial found that in the general ICU population immunonutrition has no beneficial effect on clinical outcome parameters. These results are consistent with the literature that is currently available.

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Titel: Clinical outcome of immunonutrition in a heterogeneous intensive care population
verfasst von: Hans Kieft
Arnout N. Roos
Jenneke D. E. van Drunen
Alexander J. G. H. Bindels
Jacques G. Bindels
Zandrie Hofman
Publikationsdatum: 01.04.2005
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 4/2005
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2564-x

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Clinical outcome of immunonutrition in a heterogeneous intensive care population

Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

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Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

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