Erschienen in:
01.09.2007 | Original
De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate
verfasst von:
Elpis Giantsou, Nikolaos Liratzopoulos, Eleni Efraimidou, Maria Panopoulou, Eleonora Alepopoulou, Sofia Kartali-Ktenidou, Konstantinos Manolas
Erschienen in:
Intensive Care Medicine
|
Ausgabe 9/2007
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Abstract
Objective
To assess outcomes with de-escalation therapy in ventilator-associated pneumonia (VAP).
Design
Prospective observational study.
Setting
Multidisciplinary intensive care unit.
Patients and participants
VAP was diagnosed by positive quantitative cultures of both tracheal aspirate and bronchoalveolar lavage (BAL) and treated appropriately for all significant isolates of tracheal aspirate and BAL in 143 patients who were assigned to de-escalation therapy by BAL or tracheal aspirate.
Measurements and results
Antibiotic therapy was de-escalated in 58 patients (40.5%), who had decreased mortality at day 15 (5.1% vs. 31.7%) and day 28 (12% vs. 43.5%) and shorter intensive care unit (17.2 ± 1.2 vs. 22.7 ± 6.3 days) and hospital (23.7 ± 2.8 vs. 29.8 ± 11.1 days) stay (p < 0.05). Of the 81 patients assigned to tracheal aspirate, the 17 (21%) who achieved de-escalation of therapy had reduced 15-day mortality (5.8% vs. 34.3%), reduced 28-day mortality (11.6% vs. 45.3%), and shorter intensive care unit (17.2 ± 1.6 vs. 22.4 ± 6.4 days) and hospital (23.1 ± 4.4 vs. 29.9 ± 11.1 days) stay (p < 0.05). Of the 62 patients assigned to BAL, the 41 (66.1%) who achieved de-escalation of therapy had decreased 15-day mortality (4.8% vs. 23.8%), decreased 28-day mortality (12.1% vs. 38%), and shorter intensive care unit (17.2 ± 1.1 vs. 23.2 ± 6 days) and hospital (23.8 ± 2.4 vs. 29.8 ± 11.4 days) stay (p < 0.05).
Conclusions
For patients with VAP who have had appropriate treatment and shown a favorable clinical response, mortality and duration of stay can be further improved by de-escalation therapy.