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Erschienen in: Intensive Care Medicine 7/2007

01.07.2007 | Mini-series: basic research-related topics in ICM

Alveolar epithelium and Na,K-ATPase in acute lung injury

verfasst von: István Vadász, Stacy Raviv, Jacob I. Sznajder

Erschienen in: Intensive Care Medicine | Ausgabe 7/2007

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Abstract

Active transport of sodium across the alveolar epithelium, undertaken in part by the Na,K-adenosine triphosphatase (Na,K-ATPase), is critical for clearance of pulmonary edema fluid and thus the outcome of patients with acute lung injury. Acute lung injury results in disruption of the alveolar epithelial barrier and leads to impaired clearance of edema fluid and altered Na,K-ATPase function. There has been significant progress in the understanding of mechanisms regulating alveolar edema clearance and signaling pathways modulating Na,K-ATPase function during lung injury. The accompanying review by Morty et al. focuses on intact organ and animal models as well as clinical studies assessing alveolar fluid reabsorption in alveolar epithelial injury. Elucidation of the mechanisms underlying regulation of active Na+ transport, as well as the pathways by which the Na,K-ATPase regulates epithelial barrier function and edema clearance, are of significance to identify interventional targets to improve outcomes of patients with acute lung injury.
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Metadaten
Titel
Alveolar epithelium and Na,K-ATPase in acute lung injury
verfasst von
István Vadász
Stacy Raviv
Jacob I. Sznajder
Publikationsdatum
01.07.2007
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 7/2007
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0661-8

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