Introduction
Materials and methods
Patients
Concomitant therapy
Clinical parameters
Collection of blood samples and analysis
Statistics
Results
Clinical parameters on admission
Reference values | Intubated with etomidate (n = 23) | Intubated without etomidate (n = 8) | Not intubated (n = 29) | |
---|---|---|---|---|
Age (years) | 3.7 (0.9–9.4) | 4.0 (0.8–7.6) | 4.9 (2.3–10.4) | |
Sex (M/F) | 19/4a, b
| 2/6 | 16/13 | |
Septic shock (%) | 23 (100)b
| 8 (100) | 20 (69) | |
Vasopressor score | 40 (15–60)b
| 35 (6–105)b
| 5 (0–18)a, c
| |
PRISM score | 25 (20–33)b
| 26 (18–35)b
| 17 (9–20)c
| |
Survival (%) | 16 (70)b
| 7 (88) | 29 (100)c
| |
IL-6 x 103 (pg/ml) | < 0.01 | 135.0 (40.0–853.1)b
| 63.2 (15.1–70.5) | 8.3 (1.1–80.9)c
|
Lactate (mmol/l) | < 2.0 | 4.7 (3.1–6.9)b
| 4.0 (2.6–6.8) | 3.0 (2.2–4.6)c
|
Glucose (mmol/l) | 2.6–11.0 | 5.7 (4.1–7.7)b
| 7.8 (5.5–14.2) | 7.7 (6.7–8.7)c
|
Cortisol (nmol/l) | 200–800* | 620 (502–782)a, b
| 1173 (818–1263) | 1089 (971–1346) |
ACTH (pmol/l) | < 11* | 146.1 (79.3–222.0)a, b
| 53.7 (10.8–116.0) | 14.0 (5.6–64.2) |
Cortisol/ACTH (nM/pM) | 4.7 (2.3–8.4)a, b
| 20.7 (3.5–112.7) | 89.4 (21.0–205.2) | |
11-deoxycortisol (nmol/l) | < 50* | 181 (137–248)a, b
| 49 (36–69) | 62 (44–88) |
Cortisol/11-deoxycortisol | 3.2 (2.1–4.3)a, b
| 21.6 (16.7–25.8) | 19.2 (13.6–24.5) |