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Intensive Care Medicine

Erschienen in:

01.01.2008 | Original

Hyponatremia in neurological patients: cerebral salt wasting versus inappropriate antidiuretic hormone secretion

verfasst von: Serge Brimioulle, Carlos Orellana-Jimenez, Adel Aminian, Jean-Louis Vincent

Erschienen in: Intensive Care Medicine | Ausgabe 1/2008

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Abstract

Objective

To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the cerebral salt-wasting syndrome (CSWS).

Design

Clinical, controlled, prospective study.

Setting

Department of intensive care of a tertiary care academic hospital.

Patients

Forty acute neurological patients with hyponatremia suggesting SIADH or CSWS (20) or with normonatremia (20).

Interventions

None.

Measurements and main results

Measurement of clinical and biological variables. Measurement of blood, plasma, and red blood cell volumes to discriminate SIADH and CSWS. Renal, adrenal and thyroid functions were normal in all patients. Average blood, plasma, and red blood cell volumes were 54, 37 and 17 ml/kg in control patients and 54, 37 and 18 ml/kg in hyponatremic patients, respectively.

Conclusions

The adequate blood volumes in hyponatremic patients confirm the diagnosis of SIADH and do not support the concept of CSWS.

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Titel: Hyponatremia in neurological patients: cerebral salt wasting versus inappropriate antidiuretic hormone secretion
verfasst von: Serge Brimioulle
Carlos Orellana-Jimenez
Adel Aminian
Jean-Louis Vincent
Publikationsdatum: 01.01.2008
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 1/2008
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0905-7

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