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Erschienen in: Intensive Care Medicine 2/2009

01.02.2009 | Case Discussion

Acute respiratory failure after aspiration of activated charcoal with recurrent deposition and release from an intrapulmonary cavern

verfasst von: Roland C. E. Francis, Joerg C. Schefold, Sven Bercker, Bettina Temmesfeld-Wollbrück, Wilko Weichert, Claudia D. Spies, Steffen Weber-Carstens

Erschienen in: Intensive Care Medicine | Ausgabe 2/2009

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Abstract

Objective

To report on the recurrent release of charcoal from an intrapulmonary cavern in a case of acute respiratory failure after charcoal aspiration.

Design

Case report.

Setting

Anaesthesiological ICU, university hospital.

Patient

An 18-year-old ethanol intoxicated comatose patient regurgitated and aspirated activated charcoal during orotracheal intubation.

Treatment

After 2 days of mechanical ventilation, the patient was transferred to a tertiary care university hospital. On admission, acute respiratory distress syndrome with bilateral pulmonary infiltrations was diagnosed. The patient’s recovery was hampered by recurrent release of charcoal from an intrapulmonary cavern. Sophisticated ventilatory support, prone positioning, secretolytics, repetitive bronchoscopy, and antibiotic therapy may have facilitated bronchoalveolar clearance and weaning after 18 days.

Conclusion

Aspiration may be a dramatic complication if charcoal is administered in comatose patients without airway protection. In this case report, advanced intensive care measures were necessary to tackle the special feature of charcoal release from an intrapulmonary cavern.
Literatur
1.
Zurück zum Zitat Chyka PA, Seger D, Krenzelok EP, Vale JA (2005) Position paper: single-dose activated charcoal. Clin Toxicol (Phila) 43:61–87 Chyka PA, Seger D, Krenzelok EP, Vale JA (2005) Position paper: single-dose activated charcoal. Clin Toxicol (Phila) 43:61–87
2.
Zurück zum Zitat Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, Hittarage A, Azher S, Jeganathan K, Jayamanne S, Sheriff MR, Warrell DA (2008) Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet 371:579–587PubMedCrossRef Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, Hittarage A, Azher S, Jeganathan K, Jayamanne S, Sheriff MR, Warrell DA (2008) Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet 371:579–587PubMedCrossRef
3.
Zurück zum Zitat Heard K (2006) The changing indications of gastrointestinal decontamination in poisonings. Clin Lab Med 26:1–12 viiPubMedCrossRef Heard K (2006) The changing indications of gastrointestinal decontamination in poisonings. Clin Lab Med 26:1–12 viiPubMedCrossRef
4.
Zurück zum Zitat American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists (1999) Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. J Toxicol Clin Toxicol 37:731–751CrossRef American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists (1999) Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. J Toxicol Clin Toxicol 37:731–751CrossRef
5.
Zurück zum Zitat Isbister GK, Friberg LE, Duffull SB (2006) Application of pharmacokinetic–pharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 32:1060–1065PubMedCrossRef Isbister GK, Friberg LE, Duffull SB (2006) Application of pharmacokinetic–pharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 32:1060–1065PubMedCrossRef
6.
Zurück zum Zitat Bansal RC, Goyal M (2005) Activated carbon adsorption. Taylor and Francis Ltd, London Bansal RC, Goyal M (2005) Activated carbon adsorption. Taylor and Francis Ltd, London
7.
Zurück zum Zitat Mauro LS, Nawarskas JJ, Mauro VF (1994) Misadventures with activated charcoal and recommendations for safe use. Ann Pharmacother 28:915–924PubMed Mauro LS, Nawarskas JJ, Mauro VF (1994) Misadventures with activated charcoal and recommendations for safe use. Ann Pharmacother 28:915–924PubMed
8.
Zurück zum Zitat Arnold TC, Willis BH, Xiao F, Conrad SA, Carden DL (1999) Aspiration of activated charcoal elicits an increase in lung microvascular permeability. J Toxicol Clin Toxicol 37:9–16PubMedCrossRef Arnold TC, Willis BH, Xiao F, Conrad SA, Carden DL (1999) Aspiration of activated charcoal elicits an increase in lung microvascular permeability. J Toxicol Clin Toxicol 37:9–16PubMedCrossRef
9.
Zurück zum Zitat Elliott CG, Colby TV, Kelly TM, Hicks HG (1989) Charcoal lung. Bronchiolitis obliterans after aspiration of activated charcoal. Chest 96:672–674PubMedCrossRef Elliott CG, Colby TV, Kelly TM, Hicks HG (1989) Charcoal lung. Bronchiolitis obliterans after aspiration of activated charcoal. Chest 96:672–674PubMedCrossRef
10.
Zurück zum Zitat Visscher DW, Myers JL (2006) Bronchiolitis: the pathologist’s perspective. Proc Am Thorac Soc 3:41–47PubMedCrossRef Visscher DW, Myers JL (2006) Bronchiolitis: the pathologist’s perspective. Proc Am Thorac Soc 3:41–47PubMedCrossRef
11.
Zurück zum Zitat Christ A, Arranto CA, Schindler C, Klima T, Hunziker PR, Siegemund M, Marsch SC, Eriksson U, Mueller C (2006) Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients. Intensive Care Med 32:1423–1427PubMedCrossRef Christ A, Arranto CA, Schindler C, Klima T, Hunziker PR, Siegemund M, Marsch SC, Eriksson U, Mueller C (2006) Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients. Intensive Care Med 32:1423–1427PubMedCrossRef
12.
Zurück zum Zitat Arnold TC, Zhang S, Xiao F, Conrad SA, Carden DL (2003) Pressure-controlled ventilation attenuates lung microvascular injury in a rat model of activated charcoal aspiration. J Toxicol Clin Toxicol 41:119–124PubMedCrossRef Arnold TC, Zhang S, Xiao F, Conrad SA, Carden DL (2003) Pressure-controlled ventilation attenuates lung microvascular injury in a rat model of activated charcoal aspiration. J Toxicol Clin Toxicol 41:119–124PubMedCrossRef
13.
Zurück zum Zitat Golej J, Boigner H, Burda G, Hermon M, Trittenwein G (2001) Severe respiratory failure following charcoal application in a toddler. Resuscitation 49:315–318PubMedCrossRef Golej J, Boigner H, Burda G, Hermon M, Trittenwein G (2001) Severe respiratory failure following charcoal application in a toddler. Resuscitation 49:315–318PubMedCrossRef
14.
Zurück zum Zitat Pollack MM, Dunbar BS, Holbrook PR, Fields AI (1981) Aspiration of activated charcoal and gastric contents. Ann Emerg Med 10:528–529PubMedCrossRef Pollack MM, Dunbar BS, Holbrook PR, Fields AI (1981) Aspiration of activated charcoal and gastric contents. Ann Emerg Med 10:528–529PubMedCrossRef
15.
Zurück zum Zitat Schreiber T, Hueter L, Gaser E, Schmidt B, Schwarzkopf K, Rek H, Karzai W (2006) PEEP has beneficial effects on inflammation in the injured and no deleterious effects on the noninjured lung after unilateral lung acid instillation. Intensive Care Med 32:740–749PubMedCrossRef Schreiber T, Hueter L, Gaser E, Schmidt B, Schwarzkopf K, Rek H, Karzai W (2006) PEEP has beneficial effects on inflammation in the injured and no deleterious effects on the noninjured lung after unilateral lung acid instillation. Intensive Care Med 32:740–749PubMedCrossRef
16.
Zurück zum Zitat Perkins GD, Gao F, Thickett DR (2008) In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax 63:215–220PubMedCrossRef Perkins GD, Gao F, Thickett DR (2008) In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax 63:215–220PubMedCrossRef
17.
Zurück zum Zitat Bennett WD, Almond MA, Zeman KL, Johnson JG, Donohue JF (2006) Effect of salmeterol on mucociliary and cough clearance in chronic bronchitis. Pulm Pharmacol Ther 19:96–100PubMedCrossRef Bennett WD, Almond MA, Zeman KL, Johnson JG, Donohue JF (2006) Effect of salmeterol on mucociliary and cough clearance in chronic bronchitis. Pulm Pharmacol Ther 19:96–100PubMedCrossRef
18.
Zurück zum Zitat Broadley KJ (2006) Beta-adrenoceptor responses of the airways: for better or worse? Eur J Pharmacol 533:15–27PubMedCrossRef Broadley KJ (2006) Beta-adrenoceptor responses of the airways: for better or worse? Eur J Pharmacol 533:15–27PubMedCrossRef
19.
Zurück zum Zitat Easby J, Abraham BK, Bonner SM, Graham S (2003) Prone ventilation following witnessed pulmonary aspiration: the effect on oxygenation. Intensive Care Med 29:2303–2306PubMedCrossRef Easby J, Abraham BK, Bonner SM, Graham S (2003) Prone ventilation following witnessed pulmonary aspiration: the effect on oxygenation. Intensive Care Med 29:2303–2306PubMedCrossRef
Metadaten
Titel
Acute respiratory failure after aspiration of activated charcoal with recurrent deposition and release from an intrapulmonary cavern
verfasst von
Roland C. E. Francis
Joerg C. Schefold
Sven Bercker
Bettina Temmesfeld-Wollbrück
Wilko Weichert
Claudia D. Spies
Steffen Weber-Carstens
Publikationsdatum
01.02.2009
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 2/2009
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1259-5

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