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Intensive Care Medicine

Erschienen in:

01.01.2011 | Review

Phosphorylation mechanisms in intensive care medicine

verfasst von: Erica L. Martin, V. Marco Ranieri

Erschienen in: Intensive Care Medicine | Ausgabe 1/2011

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Abstract

Introduction

The phosphorylation states of proteins, lipids, carbohydrates, amino acids, and nucleotides control the mechanisms behind nearly all cellular functions. Therefore, not surprisingly, recent findings have shown that alterations in these phosphorylation pathways play a central role in the development and progression of many disease states. This review provides a brief summary of the function and activity of various phosphorylation mechanisms, outlines some of the major phosphorylation signaling cascades, and describes the role of these phosphorylation mechanisms in intensive care medicine.

Methods

This article will comprise a comprehensive review of the literature in the context of intensive care medicine. Specifically, we will discuss the involvement of phosphorylation in the pathogenesis, diagnosis, and treatment of heart failure, myocardial infarction, stroke, respiratory failure, ventilation-induced lung injury, traumatic brain injury, acute organ failure, systemic sepsis, and shock.

Conclusion

Phosphorylation mechanisms clearly play an important role in many pathologies and treatment strategies of intensive care and therefore further understanding of these mechanisms may lead to the development of novel therapies and improved patient care.

Abraham E (2005) Alterations in cell signaling in sepsis. Clin Infect Dis 41 Suppl 7:S459–S464CrossRefPubMed

Adams JM, Difazio LT, Rolandelli RH, Lujan JJ, Hasko G, Csoka B, Selmeczy Z, Nemeth ZH (2009) HIF-1: a key mediator in hypoxia. Acta Physiol Hung 96:19–28CrossRefPubMed

Adib-Conquy M, Asehnoune K, Moine P, Cavaillon JM (2001) Long-term-impaired expression of nuclear factor-kappa B and I kappa B alpha in peripheral blood mononuclear cells of trauma patients. J Leukoc Biol 70:30–38PubMed

Agusti C, Rano A, Sibila O, Torres A (2003) Nosocomial pneumonia in immunosuppressed patients. Infect Dis Clin North Am 17:785–800CrossRefPubMed

Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaud P, Bellissant E (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862–871CrossRefPubMed

Bartha E, Kiss GN, Kalman E, Kulcsar G, Kalai T, Hideg K, Habon T, Sumegi B, Toth K, Halmosi R (2008) Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. J Cardiovasc Pharmacol 52:253–261CrossRefPubMed

Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P (2008) Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117:886–896CrossRefPubMed

Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709CrossRefPubMed

Bigalke B, Stellos K, Geisler T, Kremmer E, Seizer P, May AE, Lindemann S, Melms A, Luft A, Gawaz M (2009) Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke. Eur J Neurol 17:111–117CrossRefPubMed

10.

Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R (2008) The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther 120:172–185CrossRefPubMed

11.

Bonello L, Palot-Bonello N, Armero S, Camoin-Jau L, Paganelli F (2009) Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2 loss of function polymorphism. Int J Cardiol (Epub ahead of print)

12.

Chari R, Kim S, Murugappan S, Sanjay A, Daniel JL, Kunapuli SP (2009) Lyn, PKC delta, SHIP-1 interactions regulate GPVI-mediated platelet dense granule secretion. Blood 114:2856–2857CrossRef

13.

Chen LC, Kepka-Lenhart D, Wright TM, Morris SM Jr (1999) Salicylate-enhanced activation of transcription factors induced by interferon-gamma. Biochem J 342 Pt 3:503–507CrossRefPubMed

14.

Cheung PS, Si EC, Hosseini K (2010) Anti-inflammatory activity of azithromycin as measured by its NF-kappaB, inhibitory activity. Ocul Immunol Inflamm 18:32–37CrossRefPubMed

15.

Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M, Pittet JF (2009) Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care 13:R174CrossRefPubMed

16.

Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139–1151CrossRefPubMed

17.

Cottin V, Van Linden AA, Riches DW (2001) Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis. J Biol Chem 276:17252–17260CrossRefPubMed

18.

Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI (2003) Hypoxia-induced endocytosis of Na, K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 111:1057–1064PubMed

19.

Dash PK, Mach SA, Moore AN (2002) The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury. Neuroscience 114:755–767CrossRefPubMed

20.

Dimitrova P, Ivanovska N (2008) Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation. Int Immunopharmacol 8:1567–1577CrossRefPubMed

21.

Doukas J, Wrasidlo W, Noronha G, Dneprovskaia E, Hood J, Soll R (2007) Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction. Biochem Soc Trans 35:204–206CrossRefPubMed

22.

Fanelli V, Mascia L, Puntorieri V, Assenzio B, Elia V, Fornaro G, Martin EL, Bosco M, Delsedime L, Fiore T, Grasso S, Ranieri VM (2009) Pulmonary atelectasis during low stretch ventilation: “open lung” versus “lung rest” strategy. Crit Care Med 37:1046–1053CrossRefPubMed

23.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG (2005) Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 280:17286–17293CrossRefPubMed

24.

Griesbach GS, Gomez-Pinilla F, Hovda DA (2004) The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise. Brain Res 1016:154–162CrossRefPubMed

25.

Gundersen Y, Vaagenes P, Myhre O, Andersen JM, Pharo A, Haugen AH, Valoe E, Opstad PK (2003) Hydrocortisone and the mitogen-activated protein kinase inhibitor U0126 acutely suppress reactive oxygen species generation from circulating granulocytes after gunshot injuries in the pig. Crit Care Med 31:166–170CrossRefPubMed

26.

Hacker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006:re13

27.

Hanks SK, Quinn AM, Hunter T (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42–52CrossRefPubMed

28.

Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24:2899–2908CrossRefPubMed

29.

Hawkins PT, Anderson KE, Davidson K, Stephens LR (2006) Signalling through Class I PI3Ks in mammalian cells. Biochem Soc Trans 34:647–662CrossRefPubMed

30.

Heemskerk S, Masereeuw R, Moesker O, Bouw MP, van der Hoeven JG, Peters WH, Russel FG, Pickkers P (2009) Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med 37:417–423, e1

31.

Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, Wymann M, Montrucchio G (2001) Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J 15:2019–2021PubMed

32.

Horiguchi N, Ishac EJ, Gao B (2007) Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation. Alcohol 41:271–280CrossRefPubMed

33.

Hsieh CH, Nickel EA, Chen J, Schwacha MG, Choudhry MA, Bland KI, Chaudry IH (2009) Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation. J Immunol 182:4406–4414CrossRefPubMed

34.

Hsu JT, Kan WH, Hsieh CH, Choudhry MA, Bland KI, Chaudry IH (2009) Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage. Surgery 145:226–234CrossRefPubMed

35.

Huang Y, Cheng Y, Wu J, Li Y, Xu E, Hong Z, Li Z, Zhang W, Ding M, Gao X, Fan D, Zeng J, Wong K, Lu C, Xiao J, Yao C (2008) Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol 7:494–499CrossRefPubMed

36.

Hunter T (2000) Signaling—2000 and beyond. Cell 100:113–127CrossRefPubMed

37.

Kan WH, Hsu JT, Ba ZF, Schwacha MG, Chen J, Choudhry MA, Bland KI, Chaudry IH (2008) p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage. Am J Physiol Heart Circ Physiol 294:H2627–H2636CrossRefPubMed

38.

Karaa A, Kamoun WS, Clemens MG (2005) Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation. Shock 24:447–454CrossRefPubMed

39.

Kastl SP, Speidl WS, Katsaros KM, Kaun C, Rega G, Assadian A, Hagmueller GW, Hoeth M, de Martin R, Ma Y, Maurer G, Huber K, Wojta J (2009) Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation. Blood 114:2812–2818PubMed

40.

Kaufmann I, Briegel J, Schliephake F, Hoelzl A, Chouker A, Hummel T, Schelling G, Thiel M (2008) Stress doses of hydrocortisone in septic shock: beneficial effects on opsonization-dependent neutrophil functions. Intensive Care Med 34:344–349CrossRefPubMed

41.

Kilpatrick LE, Sun S, Korchak HM (2004) Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. Am J Physiol Cell Physiol 287:C633–C642CrossRefPubMed

42.

Kim S, Mangin P, Dangelmaier C, Lillian R, Jackson SP, Daniel JL, Kunapuli SP (2009) The role of PI 3-Kβ in glycoprotein VI-mediated akt activation in platelets. J Biol Chem 284:33763–33772

43.

Kim YS, Jung MH, Choi MY, Kim YH, Sheverdin V, Kim JH, Ha HJ, Park DJ, Kang SS, Cho GJ, Choi WS, Chang SH (2009) Glutamine attenuates tubular cell apoptosis in acute kidney injury via inhibition of the c-Jun N-terminal kinase phosphorylation of 14-3-3. Crit Care Med 37:2033–2044CrossRefPubMed

44.

Kolliputi N, Waxman AB (2009) IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation. Am J Physiol Lung Cell Mol Physiol 297:L6–L16CrossRefPubMed

45.

Krishna M, Narang H (2008) The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 65:3525–3544CrossRefPubMed

46.

Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S (2008) The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int 73:430–445CrossRefPubMed

47.

Le A, Damico R, Damarla M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Chesley A, Crow MT, Reddy SP, Tuder RM, Hassoun PM (2008) Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. J Appl Physiol 105:1282–1290CrossRefPubMed

48.

Lecker SH, Goldberg AL, Mitch WE (2006) Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17:1807–1819CrossRefPubMed

49.

Levy RM, Mollen KP, Prince JM, Kaczorowski DJ, Vallabhaneni R, Liu S, Tracey KJ, Lotze MT, Hackam DJ, Fink MP, Vodovotz Y, Billiar TR (2007) Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol 293:R1538–R1544PubMed

50.

Li S, Ye L, Yu X, Xu B, Li K, Zhu X, Liu H, Wu X, Kong L (2009) Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation. Virology 391:257–264CrossRefPubMed

51.

Lionetti V, Lisi A, Patrucco E, De Giuli P, Milazzo MG, Ceci S, Wymann M, Lena A, Gremigni V, Fanelli V, Hirsch E, Ranieri VM (2006) Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. Crit Care Med 34:134–141CrossRefPubMed

52.

Lu Y, Zhang Y, Shan H, Pan Z, Li X, Li B, Xu C, Zhang B, Zhang F, Dong D, Song W, Qiao G, Yang B (2009) MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. Cardiovasc Res 84:434–441CrossRefPubMed

53.

Martin EL, Souza DG, Fagundes CT, Amaral FA, Assenzio B, Puntorieri V, Del Sorbo L, Fanelli V, Bosco M, Delsedime L, Pinho JF, Lemos VS, Souto FO, Alves-Filho JC, Cunha FQ, Slutsky AS, Ruckle T, Hirsch E, Teixeira MM, Ranieri VM (2010) PI3Kγ kinase activity contributes to sepsis and organ damage by altering neutrophil recruitment. Am J Respir Crit Care Med (Epub ahead of print)

54.

Menschikowski M, Hagelgans A, Hempel U, Lattke P, Ismailov I, Siegert G (2008) On interaction of activated protein C with human aortic smooth muscle cells attenuating the secretory group IIA phospholipase A2 expression. Thromb Res 122:69–76CrossRefPubMed

55.

Miyahara T, Hamanaka K, Weber DS, Drake DA, Anghelescu M, Parker JC (2007) Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs. Am J Physiol Lung Cell Mol Physiol 293:L11–L21CrossRefPubMed

56.

Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH (2002) Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab 22:444–452CrossRefPubMed

57.

Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata T, Miwa A, Okado H, Kiyama H (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J Neurosci 20:2875–2886PubMed

58.

Neary JT (2005) Protein kinase signaling cascades in CNS trauma. IUBMB Life 57:711–718CrossRefPubMed

59.

Nishihara M, Miura T, Miki T, Sakamoto J, Tanno M, Kobayashi H, Ikeda Y, Ohori K, Takahashi A, Shimamoto K (2006) Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. Am J Physiol Heart Circ Physiol 291:H748–H755CrossRefPubMed

60.

Niu C, Murakami E, Furman PA (2008) Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes. Antivir Ther 13:263–269PubMed

61.

Nold MF, Nold-Petry CA, Fischer D, Richter B, Blaheta R, Pfeilschifter J, Muhl H, Schranz D, Veldman A (2007) Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in vivo model of septic shock. Thromb Haemost 98:1118–1126PubMed

62.

Noshita N, Lewen A, Sugawara T, Chan PH (2002) Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol Dis 9:294–304CrossRefPubMed

63.

Numata K, Kubo M, Watanabe H, Takagi K, Mizuta H, Okada S, Kunkel SL, Ito T, Matsukawa A (2007) Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity. J Immunol 178:3777–3785PubMed

64.

O’Kane P, Xie L, Liu Z, Queen L, Jackson G, Ji Y, Ferro A (2009) Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity. Cardiovasc Res 83:123–130CrossRefPubMed

65.

O’Shea JJ, Gadina M, Schreiber RD (2002) Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109(Suppl):S121–S131CrossRefPubMed

66.

Ohlmann P, Hechler B, Ravanat C, Loyau S, Herrenschmidt N, Wanert F, Jandrot-Perrus M, Gachet C (2008) Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression. J Thromb Haemost 6:1003–1011CrossRefPubMed

67.

Podewski EK, Hilfiker-Kleiner D, Hilfiker A, Morawietz H, Lichtenberg A, Wollert KC, Drexler H (2003) Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy. Circulation 107:798–802CrossRefPubMed

68.

Raaz U, Kuhn H, Wirtz H, Hammerschmidt S (2009) Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells. Microvasc Res 77:297–303CrossRefPubMed

69.

Rivett AJ, Bose S, Brooks P, Broadfoot KI (2001) Regulation of proteasome complexes by gamma-interferon and phosphorylation. Biochimie 83:363–366CrossRefPubMed

70.

Salvadori M, Scolari MP, Bertoni E, Citterio F, Rigotti P, Cossu M, Dal Canton A, Tisone G, Albertazzi A, Pisani F, Gubbiotti G, Piredda G, Busnach G, Sparacino V, Goepel V, Messa P, Berloco P, Montanaro D, Veroux P, Federico S, Bartezaghi M, Corbetta G, Ponticelli C (2009) Everolimus with very low-exposure cyclosporine a in de novo kidney transplantation: a multicenter, randomized, controlled trial. Transplantation 88:1194–1202CrossRefPubMed

71.

Satake A, Takaoka M, Nishikawa M, Yuba M, Shibata Y, Okumura K, Kitano K, Tsutsui H, Fujii K, Kobuchi S, Ohkita M, Matsumura Y (2008) Protective effect of 17beta-estradiol on ischemic acute renal failure through the PI3K/Akt/eNOS pathway. Kidney Int 73:308–317CrossRefPubMed

72.

Sezer M, Cimen A, Aslanger E, Elitok A, Umman B, Bugra Z, Yormaz E, Turkmen C, Adalet IS, Nisanci Y, Umman S (2009) Effect of intracoronary streptokinase administered immediately after primary percutaneous coronary intervention on long-term left ventricular infarct size, volumes, and function. J Am Coll Cardiol 54:1065–1071CrossRefPubMed

73.

Shen L, Mo H, Cai L, Kong T, Zheng W, Ye J, Qi J, Xiao Z (2009) Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. Shock 31:500–506CrossRefPubMed

74.

Shih CH, Bien MY, Chiang LL, Su CL, Lin CH, Chen BC (2009) Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts. Eur J Pharmacol 618:70–75CrossRefPubMed

75.

Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J (2008) Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:111–124CrossRefPubMed

76.

Sprung CL, Goodman S, Weiss YG (2009) Steroid therapy of septic shock. Crit Care Clin 25:825–34, x

77.

Stambe C, Atkins RC, Tesch GH, Masaki T, Schreiner GF, Nikolic-Paterson DJ (2004) The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis. J Am Soc Nephrol 15:370–379CrossRefPubMed

78.

Sun MK, Hongpaisan J, Alkon DL (2009) Postischemic PKC activation rescues retrograde and anterograde long-term memory. Proc Natl Acad Sci U S A 106:14676–14680CrossRefPubMed

79.

Takada Y, Aggarwal BB (2004) TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis. J Immunol 173:1066–1077PubMed

80.

Williams DL, Li C, Ha T, Ozment-Skelton T, Kalbfleisch JH, Preiszner J, Brooks L, Breuel K, Schweitzer JB (2004) Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J Immunol 172:449–456PubMed

81.

Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M (2008) Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 25:130–139CrossRefPubMed

82.

Yang KY, Arcaroli JJ, Abraham E (2003) Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med 167:1567–1574CrossRefPubMed

83.

Yang N, Luo M, Li R, Huang Y, Zhang R, Wu Q, Wang F, Li Y, Yu X (2008) Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat. Nephrol Dial Transplant 23:91–100CrossRefPubMed

84.

Yang WJ, Chang CJ, Yeh SH, Lin WH, Wang SH, Tsai TF, Chen DS, Chen PJ (2009) Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways. Hepatology 49:1515–1524CrossRefPubMed

85.

Yick LW, So KF, Cheung PT, Wu WT (2004) Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. J Neurotrauma 21:932–943CrossRefPubMed

86.

Zou L, Yang S, Champattanachai V, Hu S, Chaudry IH, Marchase RB, Chatham JC (2009) Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling. Am J Physiol Heart Circ Physiol 296:H515–H523CrossRefPubMed

Titel: Phosphorylation mechanisms in intensive care medicine
verfasst von: Erica L. Martin
V. Marco Ranieri
Publikationsdatum: 01.01.2011
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 1/2011
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-2023-1

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Phosphorylation mechanisms in intensive care medicine

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