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Intensive Care Medicine

Erschienen in:

01.03.2011 | Experimental

Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation

verfasst von: Te I. Weng, Hsiao Yi Wu, Chia Wei Kuo, Shing Hwa Liu

Erschienen in: Intensive Care Medicine | Ausgabe 3/2011

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Abstracts

Purpose

Sepsis has a high mortality rate despite the recent advances in intensive care medicine and antibiotics. Honokiol, a low molecular weight natural product, is known to possess anti-inflammatory activity. Here, we investigate whether honokiol can ameliorate acute lung injury and lethal response in murine models of sepsis.

Methods

Mice were intraperitoneally given vehicle or honokiol 30 min after the induction of sepsis by cecal ligation and puncture (CLP) and endotoxemia by administration of E. coli lipopolysaccharide (LPS).

Results

The productions of serum tumor necrosis factor-α (TNF-α), nitric oxide (NO), and high mobility group box 1 (HMGB 1) were increased in mice during sepsis, which could be reversed by honokiol. Honokiol could also effectively reduce the increased blood lipid peroxidation and nitrotyrosine in septic mice. Honokiol significantly reversed the inductions of inducible NO synthase and nuclear factor-κB (NF-κB) activation in the lungs of mice during sepsis. Honokiol also effectively rescued the lung edema, lung pathological changes, and lethality in septic mice.

Conclusions

These findings suggest that honokiol is capable of suppressing the lethal response and acute lung injury associated with sepsis, and support the potential use of honokiol as a therapeutic agent for the conditions associated with septic shock.

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Titel: Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation
verfasst von: Te I. Weng
Hsiao Yi Wu
Chia Wei Kuo
Shing Hwa Liu
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 3/2011
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-2104-1

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Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation

Abstracts

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstracts

Purpose

Methods

Results

Conclusions

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