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Erschienen in:
01.11.2012 | Experimental
Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges
Erschienen in: Intensive Care Medicine | Ausgabe 11/2012
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Purpose
A fall in tissue oxygen tension (tPO2) is an early indicator of organ hypoxia in both patients and animal models. We previously demonstrated the utility of bladder tPO2 in various rodent shock models. As a prelude to clinical testing, we aimed to provide further validation of bladder tPO2 monitoring in a large animal model undergoing a range of cardiorespiratory insults and vasoactive drug interventions.
Methods
Anaesthetized, mechanically ventilated, instrumented female pigs (n = 8) were subjected to a range of short-term cardiorespiratory (changes in inspired oxygen concentration (FiO2), haemorrhage, positive end-expiratory pressure) and pharmacologic (inotrope, pressor) challenges. Global haemodynamics, arterial and pulmonary blood gases and bladder tPO2 were measured before and after each challenge.
Results
Bladder tPO2 values fell in line with increasing degrees of hypoxaemia and haemorrhage, and were restored during resuscitation. These changes often preceded those seen in global haemodynamics, arterial base excess and lactate. The rise in bladder tPO2 with hyperoxia, performed as an oxygen challenge test, was incrementally blunted by progressive haemorrhage. Dobutamine and norepinephrine both increased cardiac output and global O2 delivery, but had no effect on bladder tPO2 or lactataemia in these healthy pigs.
Conclusions
In this pig model bladder tPO2 provides a sensitive indicator of organ hypoxia compared to traditional biochemical markers during various cardiorespiratory challenges. This technique offers a potentially useful tool for clinical monitoring.