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Intensive Care Medicine

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01.03.2014 | What's New in Intensive Care

What’s new in the controversy on the renal/tissue toxicity of starch solutions?

verfasst von: Norbert Lameire, Eric Hoste

Erschienen in: Intensive Care Medicine | Ausgabe 3/2014

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Excerpt

A systematic review in a recent issue of Intensive Care Medicine by Wiedermann and Joannidis [1] describes studies in which tissue accumulation of hydroxyethyl starch (HES) was documented by histological assessment. The review includes 635 patients from 37 mostly small observational studies or case reports, the majority of which used older HES preparations. …

Wiedermann CJ, Joannidis M (2013) Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review. Intensive Care Med. doi:10.1007/s00134-013-3156-9

Wittbrodt P, Haase N, Butowska D, Winding R, Poulsen JB, Perner A (2013) Quality of life and pruritus in patients with severe sepsis resuscitated with hydroxyethyl starch long-term follow-up of a randomised trial. Crit Care 17:R58PubMedCentralPubMedCrossRef

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Gattas DJ, Dan A, Myburgh J, Billot L, Lo S, Finfer S (2013) Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med 39:558–568PubMedCrossRef

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Serpa Neto A, Veelo DP, Peireira VG, de Assuncao MS, Manetta JA, Esposito DC, Schultz MJ (2013) Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta-analysis of the literature. J Crit Care. doi:10.1016/j.jcrc.2013.09.031

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Titel: What’s new in the controversy on the renal/tissue toxicity of starch solutions?
verfasst von: Norbert Lameire
Eric Hoste
Publikationsdatum: 01.03.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 3/2014
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-013-3191-6

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