Erschienen in:
01.10.2014 | Editorial
Impact of de-escalation on ICU patients’ prognosis
verfasst von:
Jan J. De Waele, Matteo Bassetti, Ignacio Martin-Loeches
Erschienen in:
Intensive Care Medicine
|
Ausgabe 10/2014
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Excerpt
De-escalation has been advocated to reduce antibiotic pressure and has become an integrated part of antimicrobial stewardship programs and antimicrobial therapy guidelines [
1]. The goal of de-escalation is to reduce the use of broad-spectrum antibiotics when bacterial susceptibility allows this. As such, it has become a necessity as proposed empirical antibiotic therapy for severe infection most often consists of multiple and broad-spectrum antibiotics. The application of de-escalation in real life is rather disappointing and ranges from 13 to 43 % [
2‐
6] depending on the definition used and context studied. …