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Intensive Care Medicine

Erschienen in:

03.09.2015 | Understanding the Disease

Understanding PK/PD

verfasst von: Jason A. Roberts, Fabio Silvio Taccone, Jeffrey Lipman

Erschienen in: Intensive Care Medicine | Ausgabe 11/2016

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Excerpt

Pharmacology is the science underpinning dosing, mechanisms of action and effectiveness of drugs. Central to pharmacology are the studies of pharmacokinetics (PK) and pharmacodynamics (PD). …

Udy AA, Varghese JM, Altukroni M, Briscoe S, McWhinney B, Ungerer J, Lipman J, Roberts JA (2012) Sub-therapeutic initial beta-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations. Chest 142:30–39CrossRefPubMed

Blot S, Lipman J, Roberts DM, Roberts JA (2014) The influence of acute kidney injury on antimicrobial dosing in critically ill patients: are dose reductions always necessary? Diagn Microbiol Infect Dis 79:77–84CrossRefPubMed

Jamal JA, Economou CJ, Lipman J, Roberts JA (2012) Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation. Curr Opin Crit Care 18:460–471CrossRefPubMed

Roberts JA, Paul SK, Akova M, Bassetti M, De Waele JJ, Dimopoulos G, Kaukonen KM, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Lipman J (2014) DALI: defining antibiotic levels in intensive care unit patients: are current beta-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis 58:1072–1083CrossRefPubMed

Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL (2014) Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis 14:498–509CrossRefPubMedPubMedCentral

Valenza G, Seifert H, Decker-Burgard S, Laeuffer J, Morrissey I, Mutters R (2012) Comparative activity of carbapenem testing (COMPACT) study in Germany. Int J Antimicrob Agents 39:255–258CrossRefPubMed

Blot S, Koulenti D, Akova M, Bassetti M, De Waele JJ, Dimopoulos G, Kaukonen KM, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Lipman J, Roberts JA (2014) Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study. Crit Care 18:R99CrossRefPubMedPubMedCentral

Roberts JA, Stove V, De Waele JJ, Sipinkoski B, McWhinney B, Ungerer JP, Akova M, Bassetti M, Dimopoulos G, Kaukonen KM, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Lipman J (2014) Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study. Int J Antimicrob Agents 43:423–430CrossRefPubMed

Sinnollareddy M, Roberts JA, Lipman J, Akova M, Bassetti M, De Waele JJ, Kaukonen K-M, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Dimopoulos G (2015) Pharmacokinetic variability and exposures of fluconazole, anidulafungin and caspofungin in intensive care unit patients: data from multinational defining antibiotic levels in intensive care unit (DALI) patients Study. Crit Care 19:33CrossRefPubMedPubMedCentral

10.

Rayner CR, Forrest A, Meagher AK, Birmingham MC, Schentag JJ (2003) Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme. Clin Pharmacokinet 42:1411–1423CrossRefPubMed

11.

Forrest A, Nix DE, Ballow CH, Goss TF, Birmingham MC, Schentag JJ (1993) Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 37:1073–1081CrossRefPubMedPubMedCentral

12.

Li C, Du X, Kuti JL, Nicolau DP (2007) Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections. Antimicrob Agents Chemother 51:1725–1730CrossRefPubMedPubMedCentral

13.

Tam VH, McKinnon PS, Akins RL, Rybak MJ, Drusano GL (2002) Pharmacodynamics of cefepime in patients with Gram-negative infections. J Antimicrob Chemother 50:425–428CrossRefPubMed

14.

Beumier M, Casu GS, Hites M, Wolff F, Cotton F, Vincent JL, Jacobs F, Taccone FS (2015) Elevated beta-lactam concentrations associated with neurological deterioration in ICU septic patients. Minerva Anestesiol 81:497–506PubMed

15.

Roberts JA, Taccone FS, Udy AA, Jacobs F, Louis J-L, Lipman J (2011) Vancomycin dosing in critically ill patients—robust methods for improved continuous infusion regimens. Antimicrob Agents Chemother 55:2704–2709CrossRefPubMedPubMedCentral

Titel: Understanding PK/PD
verfasst von: Jason A. Roberts
Fabio Silvio Taccone
Jeffrey Lipman
Publikationsdatum: 03.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 11/2016
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-015-4032-6

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