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Knee Surgery, Sports Traumatology, Arthroscopy

Erschienen in:

01.10.2008 | Knee

Graft healing in anterior cruciate ligament reconstruction

verfasst von: Max Ekdahl, James H.-C. Wang, Mario Ronga, Freddie H. Fu

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 10/2008

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Abstract

Graft healing within the bone tunnel after anterior cruciate ligament (ACL) reconstruction is still a complex, poorly understood biological process that is influenced by multiple surgical and postoperative variables. However, remarkable advances in knowledge of this process have been made based primarly on animal models. According to the findings of this review, some surgical and postoperative variables are known to directly affect time-course and quality of graft-tunnel healing. The type of graft, graft motion, and fixation methods have shown to directly affect time-course and quality of graft-tunnel healing. Therefore, the application of early and aggressive rehabilitation protocols should be cautious when using soft-tissue graft, allografts, and direct or aperture type of fixation for ACL reconstruction. With regard to graft placement, several cadaveric models showed biomechanical advantages of a more anatomical graft location; however, there are no studies that explore the relationship between graft placement and healing process. The precise effect of graft tensioning, graft/tunnel diameter disparity, and graft length within the bone tunnel in the graft healing process remains unclear and requires more research. To enhance graft-tunnel healing, tissue-engineering approaches, including the use of growth factors, mesenchymal stem cells, and periosteum graft augmentation, have been tested on animal models. These have shown promising results in terms of enhancement of bone-graft healing rate.

Abramowitch SD, Papageorgiou CD, Withrow JD et al (2003) The effect of initial graft tension on the biomechanical properties of a healing ACL replacement graft: a study in goats. J Orthop Res 21(4):708–715PubMed

Adachi N, Ochi M, Uchio Y et al (2004) Reconstruction of the anterior cruciate ligament. Single- versus double-bundle multistranded hamstring tendons. J Bone Joint Surg Br 86(4):515–520PubMed

Aglietti P, Giron F, Buzzi R et al (2004) Anterior cruciate ligament reconstruction: bone-patellar tendon-bone compared with double semitendinosus and gracilis tendon grafts. A prospective, randomized clinical trial. J Bone Joint Surg Am 86-A(10):2143–2155PubMed

Aglietti P, Giron F, Cuomo P et al (2007) Single-and double-incision double-bundle ACL reconstruction. Clin Orthop Relat Res 454:108–113PubMed

Alm A, Stromberg B (1974) Transposed medial third of patellar ligament in reconstruction of the anterior cruciate ligament. A surgical and morphologic study in dogs. Acta Chir Scand Suppl 445:37–49PubMed

Amiel D, Kleiner JB, Akeson WH (1986) The natural history of the anterior cruciate ligament autograft of patellar tendon origin. Am J Sports Med 14(6):449–462PubMed

Anderson K, Seneviratne AM, Izawa K et al (2001) Augmentation of tendon healing in an intraarticular bone tunnel with use of a bone growth factor. Am J Sports Med 29(6):689–698PubMed

Arnoczky SP (1983) Anatomy of the anterior cruciate ligament. Clin Orthop Relat Res (172):19–25

Arnoczky SP, Tarvin GB, Marshall JL (1982) Anterior cruciate ligament replacement using patellar tendon. An evaluation of graft revascularization in the dog. J Bone Joint Surg Am 64(2):217–224PubMed

10.

Au AG, Otto DD, Raso VJ et al (2005) Investigation of a hybrid method of soft tissue graft fixation for anterior cruciate ligament reconstruction. Knee 12(2):149–153PubMed

11.

Beynnon BD, Fleming BC, Johnson RJ et al (1995) Anterior cruciate ligament strain behavior during rehabilitation exercises in vivo. Am J Sports Med 23(1):24–34PubMed

12.

Beynnon BD, Johnson RJ, Fleming BC (2002) The science of anterior cruciate ligament rehabilitation. Clin Orthop Relat Res (402):9–20

13.

Beynnon BD, Johnson RJ, Fleming BC et al (1997) The strain behavior of the anterior cruciate ligament during squatting and active flexion–extension. A comparison of an open and a closed kinetic chain exercise. Am J Sports Med 25(6):823–829PubMed

14.

Brand J Jr, Weiler A, Caborn DN et al (2000) Graft fixation in cruciate ligament reconstruction. Am J Sports Med 28(5):761–774PubMed

15.

Buelow JU, Siebold R, Ellermann A (2002) A prospective evaluation of tunnel enlargement in anterior cruciate ligament reconstruction with hamstrings: extracortical versus anatomical fixation. Knee Surg Sports Traumatol Arthrosc 10(2):80–85PubMed

16.

Buoncristiani AM, Tjoumakaris FP, Starman JS et al (2006) Anatomic double-bundle anterior cruciate ligament reconstruction. Arthroscopy 22(9):1000–1006PubMed

17.

Butler DL, Grood ES, Noyes FR et al (1989) Mechanical properties of primate vascularized vs. nonvascularized patellar tendon grafts; changes over time. J Orthop Res 7(1):68–79PubMed

18.

Cain EL Jr, Clancy WG Jr (2002) Anatomic endoscopic anterior cruciate ligament reconstruction with patella tendon autograft. Orthop Clin North Am 33(4):717–725PubMed

19.

Clancy WG Jr (2006) Anatomical ACL reconstruction. In: AOSSM Annual Meeting 2006. Edited by Hershey, Pennsylvania

20.

Clancy WG Jr, Narechania RG, Rosenberg TD et al (1981) Anterior and posterior cruciate ligament reconstruction in rhesus monkeys. J Bone Joint Surg Am 63(8):1270–1284PubMed

21.

Colombet P, Robinson J, Jambou S et al (2006) Two-bundle, four-tunnel anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 14(7):629–636PubMed

22.

Cooper DE (1998) Biomechanical properties of the central third patellar tendon graft: effect of rotation. Knee Surg Sports Traumatol Arthrosc 6(Suppl 1):S16–S19PubMed

23.

Corsetti JR, Jackson DW (1996) Failure of anterior cruciate ligament reconstruction: the biologic basis. Clin Orthop Relat Res (325):42–49

24.

Cha PS, Brucker PU, West RV et al (2005) Arthroscopic double-bundle anterior cruciate ligament reconstruction: an anatomic approach. Arthroscopy 21(10):1275PubMed

25.

Chang SK, Egami DK, Shaieb MD et al (2003) Anterior cruciate ligament reconstruction: allograft versus autograft. Arthroscopy 19(5):453–462PubMed

26.

Chen CH, Chen WJ, Shih CH (2002) Enveloping of periosteum on the hamstring tendon graft in anterior cruciate ligament reconstruction. Arthroscopy 18(5):27EPubMed

27.

Chen CH, Chen WJ, Shih CH et al (2004) Arthroscopic anterior cruciate ligament reconstruction with periosteum-enveloping hamstring tendon graft. Knee Surg Sports Traumatol Arthrosc 12(5):398–405PubMed

28.

Chen CH, Chen WJ, Shih CH et al (2003) Enveloping the tendon graft with periosteum to enhance tendon-bone healing in a bone tunnel: a biomechanical and histologic study in rabbits. Arthroscopy 19(3):290–296PubMed

29.

Cho S, Muneta T, Ito S et al (2004) Electron microscopic evaluation of two-bundle anatomically reconstructed anterior cruciate ligament graft. J Orthop Sci 9(3):296–301PubMed

30.

Deehan DJ, Cawston TE (2005) The biology of integration of the anterior cruciate ligament. J Bone Joint Surg Br 87(7):889–895PubMed

31.

Eriksson K, Kindblom LG, Wredmark T (2000) Semitendinosus tendon graft ingrowth in tibial tunnel following ACL reconstruction: a histological study of 2 patients with different types of early graft failure. Acta Orthop Scand 71(3):275–279PubMed

32.

Fibbe WE (2002) Mesenchymal stem cells. A potential source for skeletal repair. Ann Rheum Dis 61(Suppl 2):ii29–ii31PubMed

33.

Fithian DC, Paxton EW, Stone ML et al (2005) Prospective trial of a treatment algorithm for the management of the anterior cruciate ligament-injured knee. Am J Sports Med 33(3):335–346PubMed

34.

Freedman KB, D’Amato MJ, Nedeff DD et al (2003) Arthroscopic anterior cruciate ligament reconstruction: a metaanalysis comparing patellar tendon and hamstring tendon autografts. Am J Sports Med 31(1):2–11PubMed

35.

George MS, Dunn WR, Spindler KP (2006) Current concepts review: revision anterior cruciate ligament reconstruction. Am J Sports Med 34(12):2026–2037PubMed

36.

Georgoulis AD, Ristanis S, Chouliaras V et al (2007) Tibial rotation is not restored after ACL reconstruction with a hamstring graft. Clin Orthop Relat Res 454:89–94PubMed

37.

Getelman MH, Friedman MJ (1999) Revision anterior cruciate ligament reconstruction surgery. J Am Acad Orthop Surg 7(3):189–198PubMed

38.

Goradia VK, Rochat MC, Kida M et al (2000) Natural history of a hamstring tendon autograft used for anterior cruciate ligament reconstruction in a sheep model. Am J Sports Med 28(1):40–46PubMed

39.

Greis PE, Burks RT, Bachus K et al (2001) The influence of tendon length and fit on the strength of a tendon-bone tunnel complex. A biomechanical and histologic study in the dog. Am J Sports Med 29(4):493–497PubMed

40.

Grood ES, Walz-Hasselfeld KA, Holden JP et al (1992) The correlation between anterior–posterior translation and cross-sectional area of anterior cruciate ligament reconstructions. J Orthop Res 10(6):878–885PubMed

41.

Hamner DL, Brown CH Jr, Steiner ME et al (1999) Hamstring tendon grafts for reconstruction of the anterior cruciate ligament: biomechanical evaluation of the use of multiple strands and tensioning techniques. J Bone Joint Surg Am 81(4):549–557PubMed

42.

Harner CD, Olson E, Irrgang JJ et al (1996) Allograft versus autograft anterior cruciate ligament reconstruction: 3- to 5-year outcome. Clin Orthop Relat Res (324):134–144

43.

Harvey A, Thomas NP, Amis AA (2005) Fixation of the graft in reconstruction of the anterior cruciate ligament. J Bone Joint Surg Br 87(5):593–603PubMed

44.

Hefzy MS, Grood ES, Noyes FR (1989) Factors affecting the region of most isometric femoral attachments. Part II: The anterior cruciate ligament. Am J Sports Med 17(2):208–216PubMed

45.

Hoher J, Livesay GA, Ma CB et al (1999) Hamstring graft motion in the femoral bone tunnel when using titanium button/polyester tape fixation. Knee Surg Sports Traumatol Arthrosc 7(4):215–219PubMed

46.

Hoher J, Moller HD, Fu FH (1998) Bone tunnel enlargement after anterior cruciate ligament reconstruction: fact or fiction? Knee Surg Sports Traumatol Arthrosc 6(4):231–240PubMed

47.

Howell SM (2006) Symposia. Sport Medicine/Arthroscopy. Controversies in Soft Tissue ACL Reconstruction: Graft, Tunnel, Fixation, Harvest. Paper presented at: Annual Meeting American Academy of Orthopaedic Surgeons; March 2006, Chicago

48.

Hunt P, Rehm O, Weiler A (2006) Soft tissue graft interference fit fixation: observations on graft insertion site healing and tunnel remodeling 2 years after ACL reconstruction in sheep. Knee Surg Sports Traumatol Arthrosc

49.

Ishibashi Y, Toh S, Okamura Y et al (2001) Graft incorporation within the tibial bone tunnel after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autograft. Am J Sports Med 29(4):473–479PubMed

50.

Jackson DW, Corsetti J, Simon TM (1996) Biologic incorporation of allograft anterior cruciate ligament replacements. Clin Orthop Relat Res (324):126–133

51.

Jackson DW, Grood ES, Arnoczky SP et al (1987) Cruciate reconstruction using freeze dried anterior cruciate ligament allograft and a ligament augmentation device (LAD). An experimental study in a goat model. Am J Sports Med 15(6):528–538PubMed

52.

Jackson DW, Grood ES, Goldstein JD et al (1993) A comparison of patellar tendon autograft and allograft used for anterior cruciate ligament reconstruction in the goat model. Am J Sports Med 21(2):176–185PubMed

53.

Jaureguito JW, Paulos LE (1996) Why grafts fail. Clin Orthop Relat Res (325):25–41

54.

Johnson DL, Swenson TM, Irrgang JJ et al (1996) Revision anterior cruciate ligament surgery: experience from Pittsburgh. Clin Orthop Relat Res (325):100–109

55.

Kawamura S, Ying L, Kim HJ et al (2005) Macrophages accumulate in the early phase of tendon-bone healing. J Orthop Res 23(6):1425–1432PubMed

56.

Kleipool AE, Zijl JA, Willems WJ (1998) Arthroscopic anterior cruciate ligament reconstruction with bone-patellar tendon-bone allograft or autograft. A prospective study with an average follow up of 4 years. Knee Surg Sports Traumatol Arthrosc 6(4):224–230PubMed

57.

Kousa P, Jarvinen TL, Vihavainen M et al (2003) The fixation strength of six hamstring tendon graft fixation devices in anterior cruciate ligament reconstruction. Part I: Femoral site. Am J Sports Med 31(2):174–181PubMed

58.

Kousa P, Jarvinen TL, Vihavainen M et al (2003) The fixation strength of six hamstring tendon graft fixation devices in anterior cruciate ligament reconstruction. Part II: Tibial site. Am J Sports Med 31(2):182–188PubMed

59.

Kyung HS, Kim SY, Oh CW et al (2003) Tendon-to-bone tunnel healing in a rabbit model: the effect of periosteum augmentation at the tendon-to-bone interface. Knee Surg Sports Traumatol Arthrosc 11(1):9–15PubMed

60.

Labs K, Perka C, Schneider F (2002) The biological and biomechanical effect of different graft tensioning in anterior cruciate ligament reconstruction: an experimental study. Arch Orthop Trauma Surg 122(4):193–199PubMed

61.

Lim JK, Hui J, Li L et al (2004) Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy 20(9):899–910PubMed

62.

Loh JC, Fukuda Y, Tsuda E et al (2003) Knee stability and graft function following anterior cruciate ligament reconstruction: comparison between 11 o’clock and 10 o’clock femoral tunnel placement. 2002 Richard O’Connor Award paper. Arthroscopy 19(3):297–304PubMed

63.

Martinek V, Latterman C, Usas A et al (2002) Enhancement of tendon-bone integration of anterior cruciate ligament grafts with bone morphogenetic protein-2 gene transfer: a histological and biomechanical study. J Bone Joint Surg Am 84-A(7):1123–1131PubMed

64.

Miller SL, Gladstone JN (2002) Graft selection in anterior cruciate ligament reconstruction. Orthop Clin North Am 33(4):675–683PubMed

65.

Muneta T, Sekiya I, Yagishita K et al (1999) Two-bundle reconstruction of the anterior cruciate ligament using semitendinosus tendon with endobuttons: operative technique and preliminary results. Arthroscopy 15(6):618–624PubMed

66.

Muneta T, Yamamoto H, Sakai H et al (1993) Relationship between changes in length and force in in vitro reconstructed anterior cruciate ligament. Am J Sports Med 21(2):299–304PubMed

67.

Musahl V, Plakseychuk A, VanScyoc A et al (2005) Varying femoral tunnels between the anatomical footprint and isometric positions: effect on kinematics of the anterior cruciate ligament-reconstructed knee. Am J Sports Med 33(5):712–718PubMed

68.

Nicholas SJ, D’Amato MJ, Mullaney MJ et al (2004) A prospectively randomized double-blind study on the effect of initial graft tension on knee stability after anterior cruciate ligament reconstruction. Am J Sports Med 32(8):1881–1886PubMed

69.

Nikolaou PK, Seaber AV, Glisson RR et al (1986) Anterior cruciate ligament allograft transplantation. Long-term function, histology, revascularization, and operative technique. Am J Sports Med 14(5):348–360PubMed

70.

Noyes FR, Butler DL, Grood ES et al (1984) Biomechanical analysis of human ligament grafts used in knee-ligament repairs and reconstructions. J Bone Joint Surg Am 66(3):344–352PubMed

71.

Noyes FR, Mangine RE, Barber S (1987) Early knee motion after open and arthroscopic anterior cruciate ligament reconstruction. Am J Sports Med 15(2):149–160PubMed

72.

Panni AS, Milano G, Lucania L et al (1997) Graft healing after anterior cruciate ligament reconstruction in rabbits. Clin Orthop Relat Res (343):203–212

73.

Papageorgiou CD, Ma CB, Abramowitch SD et al (2001) A multidisciplinary study of the healing of an intraarticular anterior cruciate ligament graft in a goat model. Am J Sports Med 29(5):620–626PubMed

74.

Park MJ, Lee MC, Seong SC (2001) A comparative study of the healing of tendon autograft and tendon-bone autograft using patellar tendon in rabbits. Int Orthop 25(1):35–39PubMed

75.

Petersen W, Laprell H (2000) Insertion of autologous tendon grafts to the bone: a histological and immunohistochemical study of hamstring and patellar tendon grafts. Knee Surg Sports Traumatol Arthrosc 8(1):26–31PubMed

76.

Pinczewski LA, Clingeleffer AJ, Otto DD et al (1997) Integration of hamstring tendon graft with bone in reconstruction of the anterior cruciate ligament. Arthroscopy 13(5):641–643PubMed

77.

Pinczewski LA, Salmon LJ, Jackson WF et al (2008) Radiological landmarks for placement of the tunnels in single-bundle reconstruction of the anterior cruciate ligament. J Bone Joint Surg Br 90(2):172–179PubMed

78.

Rihn JA, Harner CD (2003) The use of musculoskeletal allograft tissue in knee surgery. Arthroscopy 19(Suppl 1):51–66PubMed

79.

Ristanis S, Stergiou N, Patras K et al (2005) Excessive tibial rotation during high-demand activities is not restored by anterior cruciate ligament reconstruction. Arthroscopy 21(11):1323–1329PubMed

80.

Robert H, Es-Sayeh J (2004) The role of periosteal flap in the prevention of femoral widening in anterior cruciate ligament reconstruction using hamstring tendons. Knee Surg Sports Traumatol Arthrosc 12(1):30–35PubMed

81.

Rodeo SA, Arnoczky SP, Torzilli PA et al (1993) Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog. J Bone Joint Surg Am 75(12):1795–1803PubMed

82.

Rodeo SA, Kawamura S, Kim HJ et al (2006) Tendon healing in a bone tunnel differs at the tunnel entrance versus the tunnel exit: an effect of graft-tunnel motion? Am J Sports Med 34:1790–1800PubMed

83.

Rodeo SA, Suzuki K, Deng XH et al (1999) Use of recombinant human bone morphogenetic protein–2 to enhance tendon healing in a bone tunnel. Am J Sports Med 27(4):476–488PubMed

84.

Roe J, Pinczewski LA, Russell VJ et al (2005) A 7-year follow-up of patellar tendon and hamstring tendon grafts for arthroscopic anterior cruciate ligament reconstruction: differences and similarities. Am J Sports Med 33(9):1337–1345PubMed

85.

Rosen MA, Jackson DW, Atwell EA (1992) The efficacy of continuous passive motion in the rehabilitation of anterior cruciate ligament reconstructions. Am J Sports Med 20(2):122–127PubMed

86.

Rougraff B, Shelbourne KD, Gerth PK et al (1993) Arthroscopic and histologic analysis of human patellar tendon autografts used for anterior cruciate ligament reconstruction. Am J Sports Med 21(2):277–284PubMed

87.

Rougraff BT, Shelbourne KD (1999) Early histologic appearance of human patellar tendon autografts used for anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 7(1):9–14PubMed

88.

Salehpour A, Butler DL, Proch FS et al (1995) Dose-dependent response of gamma irradiation on mechanical properties and related biochemical composition of goat bone-patellar tendon-bone allografts. J Orthop Res 13(6):898–906PubMed

89.

Scheffler S (2007) Free-tendon Allografts vs. Autografts in ACL Reconstruction: Delayed Remodeling and Inferior Mechanical Properties During Long Term Healing in Sheep. Paper presented at: Arthroscopy Association of North America. 26th Annual Meeting, 2007, San Francisco

90.

Schwartz HE, Matava MJ, Proch FS et al (2006) The effect of gamma irradiation on anterior cruciate ligament allograft biomechanical and biochemical properties in the caprine model at time zero and at 6 months after surgery. Am J Sports Med 34(11):1747–1755PubMed

91.

Segawa H, Koga Y, Omori G et al (2005) Contact pressure in anterior cruciate ligament bone tunnels: comparison of endoscopic and two-incision technique. Arthroscopy 21(4):439–444PubMed

92.

Segawa H, Koga Y, Omori G et al (2003) Influence of the femoral tunnel location and angle on the contact pressure in the femoral tunnel in anterior cruciate ligament reconstruction. Am J Sports Med 31(3):444–448PubMed

93.

Shelbourne KD, Gray T (1997) Anterior cruciate ligament reconstruction with autogenous patellar tendon graft followed by accelerated rehabilitation. A 2- to 9-year followup. Am J Sports Med 25(6):786–795PubMed

94.

Sherman OH, Banffy MB (2004) Anterior cruciate ligament reconstruction: which graft is best? Arthroscopy 20(9):974–980PubMed

95.

Shino K, Kawasaki T, Hirose H et al (1984) Replacement of the anterior cruciate ligament by an allogeneic tendon graft. An experimental study in the dog. J Bone Joint Surg Br 66(5):672–681PubMed

96.

Singhatat W, Lawhorn KW, Howell SM et al (2002) How four weeks of implantation affect the strength and stiffness of a tendon graft in a bone tunnel: a study of two fixation devices in an extraarticular model in ovine. Am J Sports Med 30(4):506–513PubMed

97.

Soon MY, Hassan A, Hui JH et al (2007) An analysis of soft tissue allograft anterior cruciate ligament reconstruction in a rabbit model: a short-term study of the use of mesenchymal stem cells to enhance tendon osteointegration. Am J Sports Med 35(6):962–971PubMed

98.

Spindler KP, Kuhn JE, Freedman KB et al (2004) Anterior cruciate ligament reconstruction autograft choice: bone-tendon-bone versus hamstring: does it really matter? A systematic review. Am J Sports Med 32(8):1986–1995PubMed

99.

Spindler KP, Warren TA, Callison JC Jr et al (2005) Clinical outcome at a minimum of five years after reconstruction of the anterior cruciate ligament. J Bone Joint Surg Am 87(8):1673–1679PubMed

100.

Strocchi R, De Pasquale V, Guizzardi S et al (1992) Ultrastructural modifications of patellar tendon fibres used as anterior cruciate ligament (ACL) replacement. Ital J Anat Embryol 97(4):221–228PubMed

101.

Tashman S, Collon D, Anderson K et al (2004) Abnormal rotational knee motion during running after anterior cruciate ligament reconstruction. Am J Sports Med 32(4):975–983PubMed

102.

Tashman S, Kolowich P, Collon D et al (2007) Dynamic function of the ACL-reconstructed knee during running. Clin Orthop Relat Res 454:66–73PubMed

103.

Tocci A, Forte L (2003) Mesenchymal stem cell: use and perspectives. Hematol J 4(2):92–96PubMed

104.

Tohyama H, Yasuda K, Uchida H (2006) Is the increase in type III collagen of the patellar tendon graft after ligament reconstruction really caused by “ligamentization” of the graft? Knee Surg Sports Traumatol Arthrosc 14(12):1270–1277PubMed

105.

Tomita F, Yasuda K, Mikami S et al (2001) Comparisons of intraosseous graft healing between the doubled flexor tendon graft and the bone-patellar tendon-bone graft in anterior cruciate ligament reconstruction. Arthroscopy 17(5):461–476PubMed

106.

Tuan RS, Boland G, Tuli R (2003) Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 5(1):32–45PubMed

107.

Tyler TF, McHugh MP, Gleim GW et al (1998) The effect of immediate weightbearing after anterior cruciate ligament reconstruction. Clin Orthop Relat Res (357):141–148

108.

van Kampen A, Wymenga AB, van der Heide HJ et al (1998) The effect of different graft tensioning in anterior cruciate ligament reconstruction: a prospective randomized study. Arthroscopy 14(8):845–850PubMed

109.

Weiler A, Forster C, Hunt P et al (2004) The influence of locally applied platelet-derived growth factor-BB on free tendon graft remodeling after anterior cruciate ligament reconstruction. Am J Sports Med 32(4):881–891PubMed

110.

Weiler A, Hoffmann RF, Bail HJ et al (2002) Tendon healing in a bone tunnel. Part II: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Arthroscopy 18(2):124–135PubMed

111.

Weiler A, Peine R, Pashmineh-Azar A et al (2002) Tendon healing in a bone tunnel. Part I: Biomechanical results after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Arthroscopy 18(2):113–123PubMed

112.

West RV, Harner CD (2005) Graft selection in anterior cruciate ligament reconstruction. J Am Acad Orthop Surg 13(3):197–207PubMed

113.

Wilson TC, Kantaras A, Atay A et al (2004) Tunnel enlargement after anterior cruciate ligament surgery. Am J Sports Med 32(2):543–549PubMed

114.

Yagi M, Kuroda R, Nagamune K et al (2007) Double-bundle ACL reconstruction can improve rotational stability. Clin Orthop Relat Res 454:100–107PubMed

115.

Yamaguchi S, Sasho T, Tsuchiya A et al (2006) Long term results of anterior cruciate ligament reconstruction with iliotibial tract: 6-, 13-, and 24-year longitudinal follow-up. Knee Surg Sports Traumatol Arthrosc

116.

Yamakado K, Kitaoka K, Yamada H et al (2002) The influence of mechanical stress on graft healing in a bone tunnel. Arthroscopy 18(1):82–90PubMed

117.

Yamazaki S, Yasuda K, Tomita F et al (2002) The effect of graft-tunnel diameter disparity on intraosseous healing of the flexor tendon graft in anterior cruciate ligament reconstruction. Am J Sports Med 30(4):498–505PubMed

118.

Yamazaki S, Yasuda K, Tomita F et al (2006) The effect of intraosseous graft length on tendon-bone healing in anterior cruciate ligament reconstruction using flexor tendon. Knee Surg Sports Traumatol Arthrosc 14(11):1086–1093PubMed

119.

Yamazaki S, Yasuda K, Tomita F et al (2005) The effect of transforming growth factor-beta1 on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs. Arthroscopy 21(9):1034–1041PubMed

120.

Yasuda K, Kondo E, Ichiyama H et al (2004) Anatomic reconstruction of the anteromedial and posterolateral bundles of the anterior cruciate ligament using hamstring tendon grafts. Arthroscopy 20(10):1015–1025PubMed

121.

Yasuda K, Tsujino J, Tanabe Y et al (1997) Effects of initial graft tension on clinical outcome after anterior cruciate ligament reconstruction. Autogenous doubled hamstring tendons connected in series with polyester tapes. Am J Sports Med 25(1):99–106PubMed

122.

Yoo JC, Ahn JH, Kim JH et al (2006) Biomechanical testing of hybrid hamstring graft tibial fixation in anterior cruciate ligament reconstruction. Knee 13(6):455–459PubMed

123.

Yoshikawa T, Tohyama H, Katsura T et al (2006) Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Health Educ Behav

124.

Yoshiya S, Andrish JT, Manley MT et al (1987) Graft tension in anterior cruciate ligament reconstruction. An in vivo study in dogs. Am J Sports Med 15(5):464–470PubMed

125.

Yoshiya S, Kurosaka M, Ouchi K et al (2002) Graft tension and knee stability after anterior cruciate ligament reconstruction. Clin Orthop Relat Res (394):154–160

126.

Yoshiya S, Nagano M, Kurosaka M et al (2000) Graft healing in the bone tunnel in anterior cruciate ligament reconstruction. Clin Orthop Relat Res (376):278–286

127.

Youn I, Jones DG, Andrews PJ et al (2004) Periosteal augmentation of a tendon graft improves tendon healing in the bone tunnel. Clin Orthop Relat Res (419):223–231

128.

Yunes M, Richmond JC, Engels EA et al (2001) Patellar versus hamstring tendons in anterior cruciate ligament reconstruction: a meta-analysis. Arthroscopy 17(3):248–257PubMed

129.

Zaffagnini S, De Pasquale V, Marchesini Reggiani L et al (2006) Neoligamentization process of BTPB used for ACL graft: histological evaluation from 6 months to 10 years. Knee

130.

Zantop T, Weimann A, Schmidtko R et al (2006) Graft laceration and pullout strength of soft-tissue anterior cruciate ligament reconstruction: in vitro study comparing titanium, poly-d, l-lactide, and poly-d, l-lactide-tricalcium phosphate screws. Arthroscopy 22(11):1204–1210PubMed

131.

Zantop T, Weimann A, Wolle K et al (2007) Initial and 6 weeks postoperative structural properties of soft tissue anterior cruciate ligament reconstructions with cross-pin or interference screw fixation: an in vivo study in sheep. Arthroscopy 23(1):14–20PubMedCrossRef

132.

Zavras TD, Race A, Amis AA (2005) The effect of femoral attachment location on anterior cruciate ligament reconstruction: graft tension patterns and restoration of normal anterior–posterior laxity patterns. Knee Surg Sports Traumatol Arthrosc 13(2):92–100PubMed

133.

Zhang CL, Fan HB, Xu H et al (2006) Histological comparison of fate of ligamentous insertion after reconstruction of anterior cruciate ligament: autograft vs. allograft. Chin J Traumatol 9(2):72–76PubMed

Titel: Graft healing in anterior cruciate ligament reconstruction
verfasst von: Max Ekdahl
James H.-C. Wang
Mario Ronga
Freddie H. Fu
Publikationsdatum: 01.10.2008
Verlag: Springer-Verlag
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 10/2008
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-008-0584-0

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23.04.2024 | Leitsymptom Rückenschmerzen | Nachrichten

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Graft healing in anterior cruciate ligament reconstruction

Abstract

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Update Orthopädie und Unfallchirurgie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

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Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Update Orthopädie und Unfallchirurgie