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Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 4/2011

01.04.2011 | Knee

We do not have evidence based methods for the treatment of cartilage defects in the knee

verfasst von: Jan P. Benthien, Manuela Schwaninger, Peter Behrens

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 4/2011

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Abstract

Purpose

The aim of this study was to perform a systematic review of studies concerning current treatment of chondral defects of the knee.

Methods

The relevance for evidence based data and for successful surgical treatment of cartilage defects was evaluated. From 56,098 evaluated studies, 133 studies could be further pursued. These supplied data concerning microfracturing, the osteochondral autograft transplantation system (OATS), the autologous chondrocyte implantation (ACI) and the matrix induced chondrocyte implantation (MACI). The modified Coleman Methodical Score (CMS) and the Level of Evidence (LOE) were applied to evaluate the quality.

Results

In these studies, a total of 6,920 patients were reviewed with a median of 32 patients per study and a mean follow-up of 24 months. The mean CMS was 58 of 100 points. No study reached 100 points in the CMS. Three studies reached a level above 90. Ten studies were Level I, five studies reached Level II. Seven studies reached Level III, 111 studies Level IV. MRI scans to verify the clinical data were used by only 72 studies. The means in the modified CMS were for the different procedures as follows: ACI 58 points, MACI 57 points, microfracturing 68 points and OATS 50 points. 24 studies applied the Lysholm Score (LS) for clinical evaluation of cartilage surgery. All operative procedures yielded comparable improvements of the LS (n.s.) meaning that no operative procedure proved superior.

Conclusion

As the majority of studies evaluated by this review is insufficient for EBM purposes more coherent studies with LOE of I or II are needed. Co-relating the systems of CMS and LOE and validating the applied scores seems desirable.
Literatur
1.
Zurück zum Zitat Agneskirchner JD, Brucker P, Burkart A, Imhoff AB (2002) Large osteochondral defects of the femoral condyle: press-fit transplantation of the posterior femoral condyle (MEGA-OATS). Knee Surg Sports Traumatol Arthrosc 10:160–168PubMed Agneskirchner JD, Brucker P, Burkart A, Imhoff AB (2002) Large osteochondral defects of the femoral condyle: press-fit transplantation of the posterior femoral condyle (MEGA-OATS). Knee Surg Sports Traumatol Arthrosc 10:160–168PubMed
2.
Zurück zum Zitat Akgun I, Kesmezacar H, Ogut T, Kebudi A, Kanberoglu K (2005) Arthroscopic microfracture treatment for osteonecrosis of the knee. Arthroscopy 21:834–843PubMed Akgun I, Kesmezacar H, Ogut T, Kebudi A, Kanberoglu K (2005) Arthroscopic microfracture treatment for osteonecrosis of the knee. Arthroscopy 21:834–843PubMed
3.
Zurück zum Zitat Andereya S, Maus U, Gavenis K, Gravius S, Stanzel S, Müller-Rath R, Miltner O, Mumme T, Schneider U (2007) Treatment of patellofemoral cartilage defects utilizing a 3D collagen gel: two-year clinical results. Z Orthop Unfall 145:139–145PubMed Andereya S, Maus U, Gavenis K, Gravius S, Stanzel S, Müller-Rath R, Miltner O, Mumme T, Schneider U (2007) Treatment of patellofemoral cartilage defects utilizing a 3D collagen gel: two-year clinical results. Z Orthop Unfall 145:139–145PubMed
4.
Zurück zum Zitat Andres BM, Mears SC, Somel DS, Klug R, Wenz JF (2003) Treatment of osteoarthritic cartilage lesions with osteochondral autograft transplantation. Orthopedics 26:1121–1126PubMed Andres BM, Mears SC, Somel DS, Klug R, Wenz JF (2003) Treatment of osteoarthritic cartilage lesions with osteochondral autograft transplantation. Orthopedics 26:1121–1126PubMed
5.
Zurück zum Zitat Bachmann G, Basad E, Lommel D, Steinmeyer J (2004) MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture. Radiologe 44:773–782PubMed Bachmann G, Basad E, Lommel D, Steinmeyer J (2004) MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture. Radiologe 44:773–782PubMed
6.
Zurück zum Zitat Bae DK, Yoon KH, Song SJ (2006) Cartilage healing after microfracture in osteoarthritic knees. Arthroscopy 22:367–374PubMed Bae DK, Yoon KH, Song SJ (2006) Cartilage healing after microfracture in osteoarthritic knees. Arthroscopy 22:367–374PubMed
7.
Zurück zum Zitat Bartlett W, Gooding CR, Carrington RW, Skinner JA, Briggs TW, Bentley G (2005) Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft. A preliminary report. J Bone Joint Surg Br 87:330–332PubMed Bartlett W, Gooding CR, Carrington RW, Skinner JA, Briggs TW, Bentley G (2005) Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft. A preliminary report. J Bone Joint Surg Br 87:330–332PubMed
8.
Zurück zum Zitat Bartlett W, Skinner JA, Gooding CR, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2005) Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br 87:640–645PubMed Bartlett W, Skinner JA, Gooding CR, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2005) Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br 87:640–645PubMed
9.
Zurück zum Zitat Basad E, Ishaque B, Bachmann G, Stürz H, Steinmeyer J (2010) Matrix induced chondrocyte implantation versus microfracture in the reatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 18:519–527PubMed Basad E, Ishaque B, Bachmann G, Stürz H, Steinmeyer J (2010) Matrix induced chondrocyte implantation versus microfracture in the reatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 18:519–527PubMed
10.
Zurück zum Zitat Behrens P, Bitter T, Kurz B, Russlies M (2006) Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5- year follow-up. Knee 13:194–202PubMed Behrens P, Bitter T, Kurz B, Russlies M (2006) Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5- year follow-up. Knee 13:194–202PubMed
11.
Zurück zum Zitat Bentley G, Biant LC, Carrington RW, Akmal M, Goldberg A, Williams AM, Skinner JA, Pringle J (2003) A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 85:223–230PubMed Bentley G, Biant LC, Carrington RW, Akmal M, Goldberg A, Williams AM, Skinner JA, Pringle J (2003) A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 85:223–230PubMed
12.
Zurück zum Zitat Briggs TW, Mahroof S, David LA, Flannelly J, Pringle J, Bayliss M (2003) Histological evaluation of chondral defects after autologous chondrocyte implantation of the knee. J Bone Joint Surg Br 85:1077–1083 Briggs TW, Mahroof S, David LA, Flannelly J, Pringle J, Bayliss M (2003) Histological evaluation of chondral defects after autologous chondrocyte implantation of the knee. J Bone Joint Surg Br 85:1077–1083
13.
Zurück zum Zitat Brittberg M, Peterson L, Sjögren-Jansson E, Tallheden T, Lindahl A (2003) Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments. J Bone Joint Surg Am 85-A:109–115 Brittberg M, Peterson L, Sjögren-Jansson E, Tallheden T, Lindahl A (2003) Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments. J Bone Joint Surg Am 85-A:109–115
14.
Zurück zum Zitat Browne JE, Anderson AF, Arciero R, Mandelbaum B, Moseley JB Jr, Micheli LJ, Fu F, Erggelet C (2005) Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects. Clin Orthop Relat Res 436:237–245PubMed Browne JE, Anderson AF, Arciero R, Mandelbaum B, Moseley JB Jr, Micheli LJ, Fu F, Erggelet C (2005) Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects. Clin Orthop Relat Res 436:237–245PubMed
15.
Zurück zum Zitat Brucker R, Agneskirchner JD, Burkart A, Imhoff AB (2002) Mega-oats. Technique and results. Unfallchirurg 105:443–449PubMed Brucker R, Agneskirchner JD, Burkart A, Imhoff AB (2002) Mega-oats. Technique and results. Unfallchirurg 105:443–449PubMed
16.
Zurück zum Zitat Burkart A, Imhoff AB (2002) Treatment of articular cartilage defects with the autologous chondrocyte transplantation (ACT). Surg Technol Int 10:255–260PubMed Burkart A, Imhoff AB (2002) Treatment of articular cartilage defects with the autologous chondrocyte transplantation (ACT). Surg Technol Int 10:255–260PubMed
17.
Zurück zum Zitat Caumo F, Russo A, Faccioli N, Vecchini E, Costa A, Ricci M, Pozzi Mucelli R (2007) Autologous chondrocyte implantation: prospective MRI evaluation with clinical correlation. Radiol Med (Torino) 112:722–731 Caumo F, Russo A, Faccioli N, Vecchini E, Costa A, Ricci M, Pozzi Mucelli R (2007) Autologous chondrocyte implantation: prospective MRI evaluation with clinical correlation. Radiol Med (Torino) 112:722–731
18.
Zurück zum Zitat Chanlalit C, Kasemkijwattanamd C, Varavit V (2007) Autologous chondrocyte implantation for traumatic large cartilage defect. J Med Assoc Thai 90:1435–1444PubMed Chanlalit C, Kasemkijwattanamd C, Varavit V (2007) Autologous chondrocyte implantation for traumatic large cartilage defect. J Med Assoc Thai 90:1435–1444PubMed
19.
Zurück zum Zitat Cherubino P, Grassi FA, Bulgheroni P, Ronga M (2003) Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg 11:10–15 Cherubino P, Grassi FA, Bulgheroni P, Ronga M (2003) Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg 11:10–15
20.
Zurück zum Zitat Chow JC, Hantes ME, Houle JB, Zalavras CG (2004) Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study. Arthroscopy 20:681–690PubMed Chow JC, Hantes ME, Houle JB, Zalavras CG (2004) Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study. Arthroscopy 20:681–690PubMed
21.
Zurück zum Zitat Coleman BD, Khan KM, Maffulli N, Cook JL, Wark JD (2000) Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports 10:2–11PubMed Coleman BD, Khan KM, Maffulli N, Cook JL, Wark JD (2000) Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports 10:2–11PubMed
22.
Zurück zum Zitat Delcogliano A, Caporaso A, Menghi A, Rinonapoli G, Chiossi S (2002) Results of autologous osteochondral grafts in chondral lesions of the knee. Minerva Chir 57:273–281PubMed Delcogliano A, Caporaso A, Menghi A, Rinonapoli G, Chiossi S (2002) Results of autologous osteochondral grafts in chondral lesions of the knee. Minerva Chir 57:273–281PubMed
23.
Zurück zum Zitat Derrett S, Stokes EA, James M, Bartlett W, Bentley G (2005) Cost and health status analysis after autologous chondrocyte implantation and mosaicplasty: a retrospective comparison. Int J Technol Assess Health Care 2:359–367 Derrett S, Stokes EA, James M, Bartlett W, Bentley G (2005) Cost and health status analysis after autologous chondrocyte implantation and mosaicplasty: a retrospective comparison. Int J Technol Assess Health Care 2:359–367
24.
Zurück zum Zitat Dorotka R, Kotz R, Trattnig S, Nehrer S (2004) Mid-term results of autologous chondrocyte transplantation in knee and ankle. A one- to sixyear follow-up study. Z Rheumatol 63:385–392PubMed Dorotka R, Kotz R, Trattnig S, Nehrer S (2004) Mid-term results of autologous chondrocyte transplantation in knee and ankle. A one- to sixyear follow-up study. Z Rheumatol 63:385–392PubMed
25.
Zurück zum Zitat Dozin B, Malpeli M, Cancedda R, Bruzzi P, Calcagno S, Molfetta L, Priano F, Kon E, Marcacci M (2005) Comparative evaluation of autologous chondrocyte implantation and mosaicplasty: a multicentered randomized clinical trial. Clin J Sport Med 15:220–226PubMed Dozin B, Malpeli M, Cancedda R, Bruzzi P, Calcagno S, Molfetta L, Priano F, Kon E, Marcacci M (2005) Comparative evaluation of autologous chondrocyte implantation and mosaicplasty: a multicentered randomized clinical trial. Clin J Sport Med 15:220–226PubMed
26.
Zurück zum Zitat Drobnic M, Kregar-Velikonja N, Radosavljevic D, Gorensek M, Koritnik B, Malicev E, Wozniak G, Jeras M, Knezevic M (2002) The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee. Cell Mol Biol Lett 7:361–363PubMed Drobnic M, Kregar-Velikonja N, Radosavljevic D, Gorensek M, Koritnik B, Malicev E, Wozniak G, Jeras M, Knezevic M (2002) The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee. Cell Mol Biol Lett 7:361–363PubMed
27.
Zurück zum Zitat Emmerson BC, Görtz S, Jamali AA, Chung C, Amiel D, Bugbee WD (2007) Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle. Am J Sports Med 35:907–914PubMed Emmerson BC, Görtz S, Jamali AA, Chung C, Amiel D, Bugbee WD (2007) Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle. Am J Sports Med 35:907–914PubMed
28.
Zurück zum Zitat Farr J (2007) Autologous chondrocyte implantation improves patellofemoral cartilage treatment outcomes. Clin Orthop Relat Res 463:187–194PubMed Farr J (2007) Autologous chondrocyte implantation improves patellofemoral cartilage treatment outcomes. Clin Orthop Relat Res 463:187–194PubMed
29.
Zurück zum Zitat Ferruzzi A, Calderoni P, Grigolo B, Gualtieri G (2004) Autologous chondrocytes implantation: indications and results in the treatment of articular cartilage lesions of the knee. Chir Organi Mov 89:125–134PubMed Ferruzzi A, Calderoni P, Grigolo B, Gualtieri G (2004) Autologous chondrocytes implantation: indications and results in the treatment of articular cartilage lesions of the knee. Chir Organi Mov 89:125–134PubMed
30.
Zurück zum Zitat Fu FH, Zurakowski D, Browne JE, Mandelbaum B, Erggelet C, Moseley JB Jr, Anderson AF, Micheli LJ (2005) Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. Am J Sports Med 33:1658–1666PubMed Fu FH, Zurakowski D, Browne JE, Mandelbaum B, Erggelet C, Moseley JB Jr, Anderson AF, Micheli LJ (2005) Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. Am J Sports Med 33:1658–1666PubMed
31.
Zurück zum Zitat Gaweda K, Modrzewski K, Godlewski P, Walawski J, Krzyzanowski W (2002) Repair of focal chondral lesions of femoral condyles treated with osteochondral autografts. Chir Narzadow Ruchu Ortop Pol 67:247–253PubMed Gaweda K, Modrzewski K, Godlewski P, Walawski J, Krzyzanowski W (2002) Repair of focal chondral lesions of femoral condyles treated with osteochondral autografts. Chir Narzadow Ruchu Ortop Pol 67:247–253PubMed
32.
Zurück zum Zitat Glaser C, Tins BJ, Trumm CG, Richardson JB, Reiser MF, McCall IW (2007) Quantitative 3D MR evaluation of autologous chondrocyte implantation in the knee: feasibility and initial results. Osteoarthritis Cartilage 15:798–807PubMed Glaser C, Tins BJ, Trumm CG, Richardson JB, Reiser MF, McCall IW (2007) Quantitative 3D MR evaluation of autologous chondrocyte implantation in the knee: feasibility and initial results. Osteoarthritis Cartilage 15:798–807PubMed
33.
Zurück zum Zitat Gobbi A, Nunag P, Malinowski K (2005) Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes. Knee Surg Sports Traumatol Arthrosc 13:213–221PubMed Gobbi A, Nunag P, Malinowski K (2005) Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes. Knee Surg Sports Traumatol Arthrosc 13:213–221PubMed
34.
Zurück zum Zitat Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A (2006) A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III collagen covered. Knee 13:203–210PubMed Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A (2006) A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III collagen covered. Knee 13:203–210PubMed
35.
Zurück zum Zitat Gross AE, Aubin P, Cheah HK, Davis AM, Ghazavi MT (2002) A fresh osteochondral allograft alternative. J Arthroplasty 17:50–53PubMed Gross AE, Aubin P, Cheah HK, Davis AM, Ghazavi MT (2002) A fresh osteochondral allograft alternative. J Arthroplasty 17:50–53PubMed
36.
Zurück zum Zitat Gross AE, Shasha N, Aubin P (2005) Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects. Clin Orthop Relat Res 435:79–87PubMed Gross AE, Shasha N, Aubin P (2005) Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects. Clin Orthop Relat Res 435:79–87PubMed
37.
Zurück zum Zitat Gudas R (2002) Autologous osteochondral transplantation (mosaicplasty) in the treatment of femoral condyle defects. Medicina (Kaunas) 38:52–57 Gudas R (2002) Autologous osteochondral transplantation (mosaicplasty) in the treatment of femoral condyle defects. Medicina (Kaunas) 38:52–57
38.
Zurück zum Zitat Gudas R (2004) Clinical results after articular cartilage injury revision surgeries. Medicina (Kaunas) 40:315–319 Gudas R (2004) Clinical results after articular cartilage injury revision surgeries. Medicina (Kaunas) 40:315–319
39.
Zurück zum Zitat Gudas R, Stankevicius E, Monastyreckiene E, Pranys D, Kalesinskas RJ (2006) Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes. Knee Surg Sports Traumatol Arthrosc 14:834–842PubMed Gudas R, Stankevicius E, Monastyreckiene E, Pranys D, Kalesinskas RJ (2006) Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes. Knee Surg Sports Traumatol Arthrosc 14:834–842PubMed
40.
Zurück zum Zitat Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, Smailys A (2005) A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy 21:1066–1075PubMed Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, Smailys A (2005) A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy 21:1066–1075PubMed
41.
Zurück zum Zitat Gudas R, Kalesinskas RJ, Monastyreckiene E, Valanciūte A, Trumpickas V (2003) Osteochondral transplantation (mosaicplasty) in the treatment of knee joint cartilage defects. Medicina (Kaunas) 39:469–475 Gudas R, Kalesinskas RJ, Monastyreckiene E, Valanciūte A, Trumpickas V (2003) Osteochondral transplantation (mosaicplasty) in the treatment of knee joint cartilage defects. Medicina (Kaunas) 39:469–475
42.
Zurück zum Zitat Gudas R, Kunigiskis K, Kalensinskas RJ (2002) Long-term follow-up of osteochondrosis dissecans. Medicina (Kaunas) 38:284–288 Gudas R, Kunigiskis K, Kalensinskas RJ (2002) Long-term follow-up of osteochondrosis dissecans. Medicina (Kaunas) 38:284–288
43.
Zurück zum Zitat Haddo O, Mahroof S, Higgs D, David L, Pringle J, Bayliss M, Cannon SR, Briggs TW (2004) The use of chondrogide membrane in autologous chondrocyte implantation. Knee 11:51–55PubMed Haddo O, Mahroof S, Higgs D, David L, Pringle J, Bayliss M, Cannon SR, Briggs TW (2004) The use of chondrogide membrane in autologous chondrocyte implantation. Knee 11:51–55PubMed
44.
Zurück zum Zitat Halbrecht JL, Klick BC (2006) Improvement in bone homeostasis following autologous chondrocyte implantation of the knee. Orthopedics 29:61–69PubMed Halbrecht JL, Klick BC (2006) Improvement in bone homeostasis following autologous chondrocyte implantation of the knee. Orthopedics 29:61–69PubMed
45.
Zurück zum Zitat Handl M, Trc T, Hanus M, Stastný E, Fricová-Poulová M, Neuwirth J, Adler J, Havranová D, Varga F (2006) Therapy of severe chondral defects of the patella by autologous chondrocyte implantation. Acta Chir Orthop Traumatol Cech 73:373–379PubMed Handl M, Trc T, Hanus M, Stastný E, Fricová-Poulová M, Neuwirth J, Adler J, Havranová D, Varga F (2006) Therapy of severe chondral defects of the patella by autologous chondrocyte implantation. Acta Chir Orthop Traumatol Cech 73:373–379PubMed
46.
Zurück zum Zitat Hangody L, Ráthonyi GK, Duska Z, Vásárhelyi G, Füles P, Módis L (2004) Autologous osteochondral mosaicplasty. Surgical technique. J Bone Joint Surg Am 86-A:65–72PubMed Hangody L, Ráthonyi GK, Duska Z, Vásárhelyi G, Füles P, Módis L (2004) Autologous osteochondral mosaicplasty. Surgical technique. J Bone Joint Surg Am 86-A:65–72PubMed
47.
Zurück zum Zitat Hangody L, Füles P (2003) Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weightbearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am 85-A:25–32 Hangody L, Füles P (2003) Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weightbearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am 85-A:25–32
48.
Zurück zum Zitat Henderson I, Francisco R, Oakes B, Cameron J (2005) Autologous chondrocyte implantation for treatment of focal chondral defects of the knee—a clinical, arthroscopic, MRI and histologic evaluation at 2 years. Knee 12:209–216PubMed Henderson I, Francisco R, Oakes B, Cameron J (2005) Autologous chondrocyte implantation for treatment of focal chondral defects of the knee—a clinical, arthroscopic, MRI and histologic evaluation at 2 years. Knee 12:209–216PubMed
49.
Zurück zum Zitat Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH (2003) Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br 85:1060–1066PubMed Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH (2003) Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br 85:1060–1066PubMed
50.
Zurück zum Zitat Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13:274–279PubMed Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13:274–279PubMed
51.
Zurück zum Zitat Henderson I, Tuy B, Oakes B (2004) Reoperation after autologous chondrocyte implantation. Indications and findings. J Bone Joint Surg Br 86:205–211PubMed Henderson I, Tuy B, Oakes B (2004) Reoperation after autologous chondrocyte implantation. Indications and findings. J Bone Joint Surg Br 86:205–211PubMed
52.
Zurück zum Zitat Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH (2003) Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br 85:1060–1066PubMed Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH (2003) Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br 85:1060–1066PubMed
53.
Zurück zum Zitat Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13:274–279PubMed Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13:274–279PubMed
54.
Zurück zum Zitat Herber S, Runkel M, Pitton MB, Kalden P, Thelen M, Kreitner KF (2003) Indirect MR-arthrography in the follow up of autologous osteochondral transplantation. Rofo 175:226–233PubMed Herber S, Runkel M, Pitton MB, Kalden P, Thelen M, Kreitner KF (2003) Indirect MR-arthrography in the follow up of autologous osteochondral transplantation. Rofo 175:226–233PubMed
55.
Zurück zum Zitat Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R (2003) Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial. J Bone Joint Surg Am 85-A:185–192PubMed Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R (2003) Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial. J Bone Joint Surg Am 85-A:185–192PubMed
56.
Zurück zum Zitat Horas U, Schnettler R (2003) Chondral defects of the knee treated by transplantation of autogenous osteochondral plugs. Orthop Traumatol 10:220–234 Horas U, Schnettler R (2003) Chondral defects of the knee treated by transplantation of autogenous osteochondral plugs. Orthop Traumatol 10:220–234
57.
Zurück zum Zitat Huang H, Yin Q, Zhang Y, Zhang Y, Cao Z, Li J, Liu J (2002) Mosaicplasty osteochondral grafting to repair cartilaginous defects under arthroscopy. Zhonghua Wai Ke Za Zhi 40:662–664PubMed Huang H, Yin Q, Zhang Y, Zhang Y, Cao Z, Li J, Liu J (2002) Mosaicplasty osteochondral grafting to repair cartilaginous defects under arthroscopy. Zhonghua Wai Ke Za Zhi 40:662–664PubMed
58.
Zurück zum Zitat Jakob RP, Franz T, Gautier E, Mainil-Varlet P (2002) Autologous osteochondral grafting in the knee: indication, results, and reflections. Clin Orthop Relat Res 401:170–184PubMed Jakob RP, Franz T, Gautier E, Mainil-Varlet P (2002) Autologous osteochondral grafting in the knee: indication, results, and reflections. Clin Orthop Relat Res 401:170–184PubMed
59.
Zurück zum Zitat Jakobsen RB, Engebretsen L, Slauterbeck JR (2005) An analysis of the quality of cartilage repair studies. J Bone Joint Surg Am 87:2232–2239PubMed Jakobsen RB, Engebretsen L, Slauterbeck JR (2005) An analysis of the quality of cartilage repair studies. J Bone Joint Surg Am 87:2232–2239PubMed
60.
Zurück zum Zitat Jamali AA, Emmerson BC, Chung C, Convery FR, Bugbee WD (2005) Fresh osteochondral allografts. Clin Orthop Relat Res 437:176–185PubMed Jamali AA, Emmerson BC, Chung C, Convery FR, Bugbee WD (2005) Fresh osteochondral allografts. Clin Orthop Relat Res 437:176–185PubMed
61.
Zurück zum Zitat Jobanputra P, Parry D, Fry-Smith A, Burls A (2001) Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. Health Technol Assess 5:1–57PubMed Jobanputra P, Parry D, Fry-Smith A, Burls A (2001) Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. Health Technol Assess 5:1–57PubMed
62.
Zurück zum Zitat Karataglis D, Green MA, Learmonth DJ (2006) Autologous osteochondral transplantation for the treatment of chondral defects of the knee. Knee 13:32–35PubMed Karataglis D, Green MA, Learmonth DJ (2006) Autologous osteochondral transplantation for the treatment of chondral defects of the knee. Knee 13:32–35PubMed
63.
Zurück zum Zitat Karataglis D, Learmonth DJ (2005) Management of big osteochondral defects of the knee using osteochondral allografts with the MEGA-OATS technique. Knee 12:389–393PubMed Karataglis D, Learmonth DJ (2005) Management of big osteochondral defects of the knee using osteochondral allografts with the MEGA-OATS technique. Knee 12:389–393PubMed
64.
Zurück zum Zitat Kish G, Hangody L (2004) A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 86:619PubMed Kish G, Hangody L (2004) A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 86:619PubMed
65.
Zurück zum Zitat Klinger HM, Lorenz F, Otte S, Beyer J (2002) Treatment of cartilage defects with autologous osteochondral grafts in the knee joint. Eur J Orthop Surg Traumatol 12:26–29 Klinger HM, Lorenz F, Otte S, Beyer J (2002) Treatment of cartilage defects with autologous osteochondral grafts in the knee joint. Eur J Orthop Surg Traumatol 12:26–29
66.
Zurück zum Zitat Knutsen G, Drogset JO, Engebretsen L, Grøntvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 89:2105–2112PubMed Knutsen G, Drogset JO, Engebretsen L, Grøntvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 89:2105–2112PubMed
67.
Zurück zum Zitat Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grøntvedt T, Solheim E, Strand T, Roberts S, Isaksen V, Johansen O (2004) Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 486-A:455–464 Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grøntvedt T, Solheim E, Strand T, Roberts S, Isaksen V, Johansen O (2004) Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 486-A:455–464
68.
Zurück zum Zitat Kocher MS, Steadman JR, Briggs KK, Sterett WI, Hawkins RJ (2004) Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee. J Bone Joint Surg Am 86-A:1139–1145PubMed Kocher MS, Steadman JR, Briggs KK, Sterett WI, Hawkins RJ (2004) Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee. J Bone Joint Surg Am 86-A:1139–1145PubMed
69.
Zurück zum Zitat Koulalis D, Schultz W, Heyden M, König F (2004) Autologous osteochondral grafts in the treatment of cartilage defects of the knee joint. Knee Surg Sports Traumatol Arthrosc 12:329–334PubMed Koulalis D, Schultz W, Heyden M, König F (2004) Autologous osteochondral grafts in the treatment of cartilage defects of the knee joint. Knee Surg Sports Traumatol Arthrosc 12:329–334PubMed
70.
Zurück zum Zitat Kreuz PC, Steinwachs M, Erggelet C, Lahm A, Krause S, Ossendorf C, Meier D, Ghanem N, Uhl M (2007) Importance of sports in cartilage regeneration after autologous chondrocyte implantation: a prospective study with a 3-year follow-up. Am J Sports Med 35:1261–1268PubMed Kreuz PC, Steinwachs M, Erggelet C, Lahm A, Krause S, Ossendorf C, Meier D, Ghanem N, Uhl M (2007) Importance of sports in cartilage regeneration after autologous chondrocyte implantation: a prospective study with a 3-year follow-up. Am J Sports Med 35:1261–1268PubMed
71.
Zurück zum Zitat Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Südkamp N (2006) Results after microfracture of full-thickness chondral defects in different compartments in the Knee. Osteoarthritis Cartilage 14:1119–1125PubMed Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Südkamp N (2006) Results after microfracture of full-thickness chondral defects in different compartments in the Knee. Osteoarthritis Cartilage 14:1119–1125PubMed
72.
Zurück zum Zitat Kreuz PC, Erggelet C, Steinwachs MR, Krause SJ, Lahm A, Niemeyer P, Ghanem N, Uhl M, Südkamp N (2006) Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? Arthroscopy 11:1180–1186 Kreuz PC, Erggelet C, Steinwachs MR, Krause SJ, Lahm A, Niemeyer P, Ghanem N, Uhl M, Südkamp N (2006) Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? Arthroscopy 11:1180–1186
73.
Zurück zum Zitat Krishnan SP, Skinner JA, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2006) Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee: two- to seven-year results. J Bone Joint Surg Br 88:203–205PubMed Krishnan SP, Skinner JA, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2006) Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee: two- to seven-year results. J Bone Joint Surg Br 88:203–205PubMed
74.
Zurück zum Zitat Lahav A, Burks RT, Greis PE, Chapman AW, Ford GM, Fink BP (2006) Clinical outcomes following osteochondral autologous transplantation (OATS). J Knee Surg 19:169–173PubMed Lahav A, Burks RT, Greis PE, Chapman AW, Ford GM, Fink BP (2006) Clinical outcomes following osteochondral autologous transplantation (OATS). J Knee Surg 19:169–173PubMed
75.
Zurück zum Zitat Lange J, Follak N, Nowotny T, Merk H (2006) Results of SaluCartilage implantation for stage IV chondral defects in the knee joint area. Unfallchirurg 109:193–199PubMed Lange J, Follak N, Nowotny T, Merk H (2006) Results of SaluCartilage implantation for stage IV chondral defects in the knee joint area. Unfallchirurg 109:193–199PubMed
76.
Zurück zum Zitat LaPrade RF (2003) Autologous chondrocyte implantation was superior to mosaicplasty for repair of articular cartilage defects in the knee at one year. J Bone Joint Surg Am 85-A:2259PubMed LaPrade RF (2003) Autologous chondrocyte implantation was superior to mosaicplasty for repair of articular cartilage defects in the knee at one year. J Bone Joint Surg Am 85-A:2259PubMed
77.
Zurück zum Zitat Lehman RC, Perry CR (2003) Modified osteochondral autograft implantation for full- thickness articular cartilage lesions. Arthroscopy 19:318–320PubMed Lehman RC, Perry CR (2003) Modified osteochondral autograft implantation for full- thickness articular cartilage lesions. Arthroscopy 19:318–320PubMed
78.
Zurück zum Zitat Liebau C, Baltzer AW, Arnold J, Bartmann T, Behnke B, Koch H, Merk H (2003) Experiences after 150 cartilage-bone-transplantations of the knee: a prospective analysis of the results. Zentralbl Chir 128:511–516PubMed Liebau C, Baltzer AW, Arnold J, Bartmann T, Behnke B, Koch H, Merk H (2003) Experiences after 150 cartilage-bone-transplantations of the knee: a prospective analysis of the results. Zentralbl Chir 128:511–516PubMed
79.
Zurück zum Zitat Lubowitz JH, Appleby D, Centeno JM, Woolf SK, Reid JB 3rd (2007) The relationship between the outcome of studies of autologous chondrocyte implantation and the presence of commercial funding. Am J Sports Med 35:1809–1816PubMed Lubowitz JH, Appleby D, Centeno JM, Woolf SK, Reid JB 3rd (2007) The relationship between the outcome of studies of autologous chondrocyte implantation and the presence of commercial funding. Am J Sports Med 35:1809–1816PubMed
80.
Zurück zum Zitat Ma HL, Hung SC, Wang ST, Chang MC, Chen TH (2004) Osteochondral autografts transfer for post-traumatic osteochondral defect of the knee-2 to 5 years follow-up. Injury 35:1286–1292PubMed Ma HL, Hung SC, Wang ST, Chang MC, Chen TH (2004) Osteochondral autografts transfer for post-traumatic osteochondral defect of the knee-2 to 5 years follow-up. Injury 35:1286–1292PubMed
81.
Zurück zum Zitat Mandelbaum B, Browne JE, Fu F, Micheli LJ, Moseley JB Jr, Erggelet C, Anderson AF (2007) Treatment outcomes of autologous chondrocyte implantation for full-thickness articular cartilage defects of the trochlea. Am J Sports Med 35:915–921PubMed Mandelbaum B, Browne JE, Fu F, Micheli LJ, Moseley JB Jr, Erggelet C, Anderson AF (2007) Treatment outcomes of autologous chondrocyte implantation for full-thickness articular cartilage defects of the trochlea. Am J Sports Med 35:915–921PubMed
82.
Zurück zum Zitat Manfredini M, Zerbinati F, Gildone A, Faccini R (2007) Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique. Acta Orthop Belg 73:207–218PubMed Manfredini M, Zerbinati F, Gildone A, Faccini R (2007) Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique. Acta Orthop Belg 73:207–218PubMed
83.
Zurück zum Zitat Marcacci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, Kon E, Pederzini L, Rosa D, Sacchetti GL, Stefani G, Zanasi S (2005) Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435:96–105PubMed Marcacci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, Kon E, Pederzini L, Rosa D, Sacchetti GL, Stefani G, Zanasi S (2005) Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435:96–105PubMed
84.
Zurück zum Zitat Marcacci M, Kon E, Delcogliano M, Filardo G, Busacca M, Zaffagnini S (2007) Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med 35:2014–2021PubMed Marcacci M, Kon E, Delcogliano M, Filardo G, Busacca M, Zaffagnini S (2007) Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med 35:2014–2021PubMed
85.
Zurück zum Zitat Marcacci M, Kon E, Zaffagnini S, Filardo G, Delcogliano M, Neri MP, Iacono F, Hollander AP (2007) Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc 15:610–619PubMed Marcacci M, Kon E, Zaffagnini S, Filardo G, Delcogliano M, Neri MP, Iacono F, Hollander AP (2007) Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc 15:610–619PubMed
86.
Zurück zum Zitat Marcacci M, Kon E, Zaffagnini S, Iacono F, Neri MP, Vascellari A, Visani A, Russo A (2005) Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy 21:462–470PubMed Marcacci M, Kon E, Zaffagnini S, Iacono F, Neri MP, Vascellari A, Visani A, Russo A (2005) Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy 21:462–470PubMed
87.
Zurück zum Zitat Marder RA, Hopkins G Jr, Timmerman LA (2005) Arthroscopic microfracture of chondral defects of the knee: a comparison of two postoperative treatments. Arthroscopy 21:152–158PubMed Marder RA, Hopkins G Jr, Timmerman LA (2005) Arthroscopic microfracture of chondral defects of the knee: a comparison of two postoperative treatments. Arthroscopy 21:152–158PubMed
88.
Zurück zum Zitat Marlovits S, Kutscha-Lissberg F, Aldrian S, Resinger C, Singer P, Zeller P, Vécsei V (2004) Autologous chondrocyte transplantation for the treatment of articular cartilage defects in the knee joint. Techniques and results. Radiologe 44:763–772PubMed Marlovits S, Kutscha-Lissberg F, Aldrian S, Resinger C, Singer P, Zeller P, Vécsei V (2004) Autologous chondrocyte transplantation for the treatment of articular cartilage defects in the knee joint. Techniques and results. Radiologe 44:763–772PubMed
89.
Zurück zum Zitat Matsunaga D, Akizuki S, Takizawa T, Yamazaki I, Kuraishi J (2007) Repair of articular cartilage and clinical outcome after osteotomy with microfracture or abrasion arthroplasty for medial gonarthrosis. Knee 14:465–471PubMed Matsunaga D, Akizuki S, Takizawa T, Yamazaki I, Kuraishi J (2007) Repair of articular cartilage and clinical outcome after osteotomy with microfracture or abrasion arthroplasty for medial gonarthrosis. Knee 14:465–471PubMed
90.
Zurück zum Zitat McCulloch PC, Kang RW, Sobhy MH, Hayden JK, Cole BJ (2007) Prospective evaluation of prolonged fresh osteochondral allograft transplantation of the femoral condyle: minimum 2-year follow-up. Am J Sports Med 35:411–420PubMed McCulloch PC, Kang RW, Sobhy MH, Hayden JK, Cole BJ (2007) Prospective evaluation of prolonged fresh osteochondral allograft transplantation of the femoral condyle: minimum 2-year follow-up. Am J Sports Med 35:411–420PubMed
91.
Zurück zum Zitat Meenen NM, Rischke B (2003) Autogenous osteochondral transplantation (AOT) for cartilaginous defects of the femoral condyle. Oper Orthop Traumatol 15:38–56 Meenen NM, Rischke B (2003) Autogenous osteochondral transplantation (AOT) for cartilaginous defects of the femoral condyle. Oper Orthop Traumatol 15:38–56
92.
Zurück zum Zitat Micheli LJ, Moseley JB, Anderson AF, Browne JE, Erggelet C, Arciero R, Fu FH, Mandelbaum BR (2006) Articular cartilage defects of the distal femur in children and adolescents: treatment with autologous chondrocyte implantation. J Pediatr Orthop 26:455–460PubMed Micheli LJ, Moseley JB, Anderson AF, Browne JE, Erggelet C, Arciero R, Fu FH, Mandelbaum BR (2006) Articular cartilage defects of the distal femur in children and adolescents: treatment with autologous chondrocyte implantation. J Pediatr Orthop 26:455–460PubMed
93.
Zurück zum Zitat Miller BS, Steadman JR, Briggs KK, Rodrigo JJ, Rodkey WG (2004) Patient satisfaction and outcome after microfracture of the degenerative knee. J Knee Surg 17:13–17PubMed Miller BS, Steadman JR, Briggs KK, Rodrigo JJ, Rodkey WG (2004) Patient satisfaction and outcome after microfracture of the degenerative knee. J Knee Surg 17:13–17PubMed
94.
Zurück zum Zitat Minas T, Bryant T (2005) The role of autologous chondrocyte implantation in the patellofemoral joint. Clin Orthop Relat Res 436:30–39PubMed Minas T, Bryant T (2005) The role of autologous chondrocyte implantation in the patellofemoral joint. Clin Orthop Relat Res 436:30–39PubMed
95.
Zurück zum Zitat Miniaci A, Tytherleigh-Strong G (2007) Fixation of unstable osteochondritis dissecans lesions of the knee using arthroscopic autogenous osteochondral grafting (mosaicplasty). Arthroscopy 23:845–851PubMed Miniaci A, Tytherleigh-Strong G (2007) Fixation of unstable osteochondritis dissecans lesions of the knee using arthroscopic autogenous osteochondral grafting (mosaicplasty). Arthroscopy 23:845–851PubMed
96.
Zurück zum Zitat Mithöfer K, Minas T, Peterson L, Yeon H, Micheli LJ (2005) Functional outcome of knee articular cartilage repair in adolescent athletes. Am J Sports Med 33:1147–1153PubMed Mithöfer K, Minas T, Peterson L, Yeon H, Micheli LJ (2005) Functional outcome of knee articular cartilage repair in adolescent athletes. Am J Sports Med 33:1147–1153PubMed
97.
Zurück zum Zitat Mithöfer K, Peterson L, Mandelbaum BR, Minas T (2005) Articular cartilage repair in soccer players with autologous chondrocyte transplantation: functional outcome and return to competition. Am J Sports Med 33:1639–1646PubMed Mithöfer K, Peterson L, Mandelbaum BR, Minas T (2005) Articular cartilage repair in soccer players with autologous chondrocyte transplantation: functional outcome and return to competition. Am J Sports Med 33:1639–1646PubMed
98.
Zurück zum Zitat Mithoefer K, Williams RJ 3rd, Warren RF, Potter HG, Spock CR, Jones EC, Wickiewicz TL, Marx RG (2006) Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. Surgical technique. J Bone Joint Surg Am 88:294–304PubMed Mithoefer K, Williams RJ 3rd, Warren RF, Potter HG, Spock CR, Jones EC, Wickiewicz TL, Marx RG (2006) Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. Surgical technique. J Bone Joint Surg Am 88:294–304PubMed
99.
Zurück zum Zitat Mithoefer K, Williams RJ 3rd, Warren RF, Potter HG, Spock CR, Jones EC, Wickiewicz TL, Marx RG (2005) The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. J Bone Joint Surg Am 87:1911–1920PubMed Mithoefer K, Williams RJ 3rd, Warren RF, Potter HG, Spock CR, Jones EC, Wickiewicz TL, Marx RG (2005) The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. J Bone Joint Surg Am 87:1911–1920PubMed
100.
Zurück zum Zitat Mithoefer K, Williams RJ 3rd, Warren RF, Wickiewicz TL, Marx RG (2006) High-impact athletics after knee articular cartilage repair: a prospective evaluation of the microfracture technique. Am J Sports Med 34:1413–1418PubMed Mithoefer K, Williams RJ 3rd, Warren RF, Wickiewicz TL, Marx RG (2006) High-impact athletics after knee articular cartilage repair: a prospective evaluation of the microfracture technique. Am J Sports Med 34:1413–1418PubMed
101.
Zurück zum Zitat Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR (2009) Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence based systematic analysis. Am J Sports Med 37:2053–2063PubMed Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR (2009) Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence based systematic analysis. Am J Sports Med 37:2053–2063PubMed
102.
Zurück zum Zitat Moriya T, Wada Y, Watanabe A, Sasho T, Nakagawa K, Mainil-Varlet P, Moriya H (2007) Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. J Orthop Sci 12:265–273PubMed Moriya T, Wada Y, Watanabe A, Sasho T, Nakagawa K, Mainil-Varlet P, Moriya H (2007) Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. J Orthop Sci 12:265–273PubMed
103.
Zurück zum Zitat Nakagawa Y, Matsusue Y, Suzuki T, Kuroki H, Nakamura T (2004) Osteochondral grafting for cartilage defects in the patellar grooves of bilateral knee joints. Arthroscopy 20:32–38PubMed Nakagawa Y, Matsusue Y, Suzuki T, Kuroki H, Nakamura T (2004) Osteochondral grafting for cartilage defects in the patellar grooves of bilateral knee joints. Arthroscopy 20:32–38PubMed
104.
Zurück zum Zitat Nakagawa Y, Suzuki T, Kuroki H, Kobayashi M, Okamoto Y, Nakamura T (2007) The effect of surface incongruity of grafted plugs in osteochondral grafting: a report of five cases. Knee Surg Sports Traumatol Arthrosc 15:591–596PubMed Nakagawa Y, Suzuki T, Kuroki H, Kobayashi M, Okamoto Y, Nakamura T (2007) The effect of surface incongruity of grafted plugs in osteochondral grafting: a report of five cases. Knee Surg Sports Traumatol Arthrosc 15:591–596PubMed
105.
Zurück zum Zitat Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R (2006) Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 57:3–8PubMed Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R (2006) Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 57:3–8PubMed
106.
Zurück zum Zitat Niemeyer P, Kreuz PC, Steinwachs M, Köstler W, Mehlhorn A, Kraft N, Südkamp NP (2007) Technical note: the “double eye” technique as a modification of autologous chondrocyte implantation for the treatment of retropatellar cartilage defects. Knee Surg Sports Traumatol Arthrosc 15:1461–1468PubMed Niemeyer P, Kreuz PC, Steinwachs M, Köstler W, Mehlhorn A, Kraft N, Südkamp NP (2007) Technical note: the “double eye” technique as a modification of autologous chondrocyte implantation for the treatment of retropatellar cartilage defects. Knee Surg Sports Traumatol Arthrosc 15:1461–1468PubMed
107.
Zurück zum Zitat Niemeyer P, Kreuz PC, Steinwachs M, Südkamp NP (2007) Operative treatment of cartilage lesions in the knee joint. Sportverletz Sportschaden 21:41–50PubMed Niemeyer P, Kreuz PC, Steinwachs M, Südkamp NP (2007) Operative treatment of cartilage lesions in the knee joint. Sportverletz Sportschaden 21:41–50PubMed
108.
Zurück zum Zitat Ochi M, Uchio Y, Kawasaki K, Wakitani S, Iwasa J (2002) Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee. J Bone Joint Surg Br 84:571–578PubMed Ochi M, Uchio Y, Kawasaki K, Wakitani S, Iwasa J (2002) Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee. J Bone Joint Surg Br 84:571–578PubMed
109.
Zurück zum Zitat Orljanski W, Aghayev E, Zazirnyj I, Schabus R (2005) Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral grafts. Acta Chir Orthop Traumatol Cech 72:246–249PubMed Orljanski W, Aghayev E, Zazirnyj I, Schabus R (2005) Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral grafts. Acta Chir Orthop Traumatol Cech 72:246–249PubMed
110.
Zurück zum Zitat Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C (2007) Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther 9:R41PubMed Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C (2007) Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther 9:R41PubMed
111.
Zurück zum Zitat Ossendorf C, Kreuz PC, Steinwachs MR, Erggelet C (2007) Autologous chondrocyte implantation for the treatment of large full-thickness cartilage lesions of the knee. Saudi Med J 28:1251–1256PubMed Ossendorf C, Kreuz PC, Steinwachs MR, Erggelet C (2007) Autologous chondrocyte implantation for the treatment of large full-thickness cartilage lesions of the knee. Saudi Med J 28:1251–1256PubMed
112.
Zurück zum Zitat Oztürk A, Ozdemir MR, Ozkan Y (2006) Osteochondral autografting (mosaicplasty) in grade IV cartilage defects in the knee joint: 2- to 7-year results. Int Orthop 30:200–204PubMed Oztürk A, Ozdemir MR, Ozkan Y (2006) Osteochondral autografting (mosaicplasty) in grade IV cartilage defects in the knee joint: 2- to 7-year results. Int Orthop 30:200–204PubMed
113.
Zurück zum Zitat Pavesio A, Abatangelo G, Borrione A, Brocchetta D, Hollander AP, Kon E, Torasso F, Zanasi S, Marcacci M (2003) Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp 249:203–217PubMed Pavesio A, Abatangelo G, Borrione A, Brocchetta D, Hollander AP, Kon E, Torasso F, Zanasi S, Marcacci M (2003) Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp 249:203–217PubMed
114.
Zurück zum Zitat Peterson L (2006) ACI surgical technique and results at 2–10 years. In: Zanasi S, Brittberg M, Marcacci M (eds) Basic science, clinical repair and reconstruction of articular cartilage defects: current status and prospects. Timeo, Bologna, pp 325–330 Peterson L (2006) ACI surgical technique and results at 2–10 years. In: Zanasi S, Brittberg M, Marcacci M (eds) Basic science, clinical repair and reconstruction of articular cartilage defects: current status and prospects. Timeo, Bologna, pp 325–330
115.
Zurück zum Zitat Peterson L, Minas T, Brittberg M, Lindahl A (2003) Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am 85-A:17–24PubMed Peterson L, Minas T, Brittberg M, Lindahl A (2003) Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am 85-A:17–24PubMed
116.
Zurück zum Zitat Podskubka A, Povýsil C, Kubes R, Sprindrich J, Sedlácek R (2006) Treatment of deep cartilage defects of the knee with autologous chondrocyte transplantation on a hyaluronic Acid ester scaffolds (Hyalograft C). Acta Chir Orthop Traumatol Cech 73:251–263PubMed Podskubka A, Povýsil C, Kubes R, Sprindrich J, Sedlácek R (2006) Treatment of deep cartilage defects of the knee with autologous chondrocyte transplantation on a hyaluronic Acid ester scaffolds (Hyalograft C). Acta Chir Orthop Traumatol Cech 73:251–263PubMed
117.
Zurück zum Zitat Robert H, Bahuaud J, Kerdiles N, Passuti N, Capelli M, Pujol JP, Hartman D, Locker B, Hulet C, Hardy P, Coudane H, Rochverger A, Francheschi JP et al.; Société Française d’Arthroscopie (2007) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation: a review of 28 cases. Rev Chir Orthop Reparatrice Appar Mot 93:701–709 Robert H, Bahuaud J, Kerdiles N, Passuti N, Capelli M, Pujol JP, Hartman D, Locker B, Hulet C, Hardy P, Coudane H, Rochverger A, Francheschi JP et al.; Société Française d’Arthroscopie (2007) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation: a review of 28 cases. Rev Chir Orthop Reparatrice Appar Mot 93:701–709
118.
Zurück zum Zitat Roberts S, McCall IW, Darby AJ, Menage J, Evans H, Harrison PE, Richardson JB (2003) Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Res Ther 5:R60–R73PubMed Roberts S, McCall IW, Darby AJ, Menage J, Evans H, Harrison PE, Richardson JB (2003) Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Res Ther 5:R60–R73PubMed
119.
Zurück zum Zitat Robertson WB, Fick D, Wood DJ, Linklater JM, Zheng MH, Ackland TR (2007) MRI and clinical evaluation of collagen-covered autologous chondrocyte implantation (CACI) at two years. Knee 14:117–127PubMed Robertson WB, Fick D, Wood DJ, Linklater JM, Zheng MH, Ackland TR (2007) MRI and clinical evaluation of collagen-covered autologous chondrocyte implantation (CACI) at two years. Knee 14:117–127PubMed
120.
Zurück zum Zitat Ronga M, Grassi FA, Bulgheroni P (2004) Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy 20:79–84PubMed Ronga M, Grassi FA, Bulgheroni P (2004) Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy 20:79–84PubMed
121.
Zurück zum Zitat Rose T, Lill H, Hepp P, Josten C (2005) Autologous osteochondral mosaicplasty for treatment of a posttraumatic defect of the lateral tibial plateau: a case report with two-year follow-up. J Orthop Trauma 19:217–222PubMed Rose T, Lill H, Hepp P, Josten C (2005) Autologous osteochondral mosaicplasty for treatment of a posttraumatic defect of the lateral tibial plateau: a case report with two-year follow-up. J Orthop Trauma 19:217–222PubMed
122.
Zurück zum Zitat Schneider U, Andereya S (2003) First results of a prospective randomized clinical trial on traditional chondrocyte transplantation vs CaReS-Technology. Z Orthop Ihre Grenzgeb 141:496–497PubMed Schneider U, Andereya S (2003) First results of a prospective randomized clinical trial on traditional chondrocyte transplantation vs CaReS-Technology. Z Orthop Ihre Grenzgeb 141:496–497PubMed
123.
Zurück zum Zitat Scorrano A, Biggi F, Turi G (2004) Autologous chondrocyte implantation for focal cartilage defects in athletes: Histology and second-look arthroscopy. J Orthop Traumatol 5:98–105 Scorrano A, Biggi F, Turi G (2004) Autologous chondrocyte implantation for focal cartilage defects in athletes: Histology and second-look arthroscopy. J Orthop Traumatol 5:98–105
124.
Zurück zum Zitat Sharpe JR, Ahmed SU, Fleetcroft JP, Martin R (2005) The treatment of osteochondral lesions using a combination of autologous chondrocyte implantation and autograft: three-year follow-up. J Bone Joint Surg Br 87:730–735PubMed Sharpe JR, Ahmed SU, Fleetcroft JP, Martin R (2005) The treatment of osteochondral lesions using a combination of autologous chondrocyte implantation and autograft: three-year follow-up. J Bone Joint Surg Br 87:730–735PubMed
125.
Zurück zum Zitat Shasha N, Aubin PP, Cheah HK, Davis AM, Agnidis Z, Gross AE (2002) Long-term clinical experience with fresh osteochondral allografts for articular knee defects in high demand patients. Cell Tissue Bank 3:175–182PubMed Shasha N, Aubin PP, Cheah HK, Davis AM, Agnidis Z, Gross AE (2002) Long-term clinical experience with fresh osteochondral allografts for articular knee defects in high demand patients. Cell Tissue Bank 3:175–182PubMed
126.
Zurück zum Zitat Shasha N, Krywulak S, Backstein D, Pressman A, Gross AE (2003) Long-term follow-up of fresh tibial osteochondral allografts for failed tibial plateau fractures. J Bone Joint Surg Am 85-A:33–39PubMed Shasha N, Krywulak S, Backstein D, Pressman A, Gross AE (2003) Long-term follow-up of fresh tibial osteochondral allografts for failed tibial plateau fractures. J Bone Joint Surg Am 85-A:33–39PubMed
127.
Zurück zum Zitat Spak TR, Teitge RA (2006) Fresh osteochondral allografts for patellofemoral arthritis: long-term followup. Clin Orthop Relat Res 444:193–200 Spak TR, Teitge RA (2006) Fresh osteochondral allografts for patellofemoral arthritis: long-term followup. Clin Orthop Relat Res 444:193–200
128.
Zurück zum Zitat Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG (2003) Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 19:477–484PubMed Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG (2003) Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 19:477–484PubMed
129.
Zurück zum Zitat Steadman JR, Miller BS, Karas SG, Schlegel TF, Briggs KK, Hawkins RJ (2003) The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players. J Knee Surg 16:83–86PubMed Steadman JR, Miller BS, Karas SG, Schlegel TF, Briggs KK, Hawkins RJ (2003) The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players. J Knee Surg 16:83–86PubMed
130.
Zurück zum Zitat Steinwachs M, Kreuz PC (2007) Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up. Arthroscopy 23:381–387PubMed Steinwachs M, Kreuz PC (2007) Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up. Arthroscopy 23:381–387PubMed
131.
Zurück zum Zitat Takahashi T, Tins B, McCall IW, Richardson JB, Takagi K, Ashton K (2006) MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome. Skeletal Radiol 35:16–26PubMed Takahashi T, Tins B, McCall IW, Richardson JB, Takagi K, Ashton K (2006) MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome. Skeletal Radiol 35:16–26PubMed
132.
Zurück zum Zitat Tins BJ, McCall IW, Takahashi T, Cassar-Pullicino V, Roberts S, Ashton B, Richardson J (2005) Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1- year follow-up. Radiology 234:501–508PubMed Tins BJ, McCall IW, Takahashi T, Cassar-Pullicino V, Roberts S, Ashton B, Richardson J (2005) Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1- year follow-up. Radiology 234:501–508PubMed
133.
Zurück zum Zitat Trattnig S, Ba-Ssalamah A, Pinker K, Plank C, Vecsei V, Marlovits S (2005) Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging. Magn Reson Imaging 23:779–787PubMed Trattnig S, Ba-Ssalamah A, Pinker K, Plank C, Vecsei V, Marlovits S (2005) Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging. Magn Reson Imaging 23:779–787PubMed
134.
Zurück zum Zitat Trattnig S, Pinker K, Krestan C, Plank C, Millington S, Marlovits S (2006) Matrix-based autologous chondrocyte implantation for cartilage repair with Hyalograft C: two-year follow-up by magnetic resonance imaging. Eur J Radiol 57:9–15PubMed Trattnig S, Pinker K, Krestan C, Plank C, Millington S, Marlovits S (2006) Matrix-based autologous chondrocyte implantation for cartilage repair with Hyalograft C: two-year follow-up by magnetic resonance imaging. Eur J Radiol 57:9–15PubMed
135.
Zurück zum Zitat Trzaska T, Rapala K (2003) Osteochondral transplantation in the treatment of knee joint cartilage defects. Polski Przeglad Chirurgiczny 75:154–163 Trzaska T, Rapala K (2003) Osteochondral transplantation in the treatment of knee joint cartilage defects. Polski Przeglad Chirurgiczny 75:154–163
136.
Zurück zum Zitat Ueblacker P, Burkart A, Imhoff AB (2004) Retrograde cartilage transplantation on the proximal and distal tibia. Arthroscopy 20:73–78PubMed Ueblacker P, Burkart A, Imhoff AB (2004) Retrograde cartilage transplantation on the proximal and distal tibia. Arthroscopy 20:73–78PubMed
137.
Zurück zum Zitat Vanlauwe J, Almqvist F, Bellemans J, Huskin JP, Verdonk R, Victor J (2007) Repair of symptomatic cartilage lesions of the knee: the place of autologous chondrocyte implantation. Acta Orthop Belg 73:145–158PubMed Vanlauwe J, Almqvist F, Bellemans J, Huskin JP, Verdonk R, Victor J (2007) Repair of symptomatic cartilage lesions of the knee: the place of autologous chondrocyte implantation. Acta Orthop Belg 73:145–158PubMed
138.
Zurück zum Zitat Vasara AI, Nieminen MT, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I (2005) Indentation stiffness of repair tissue after autologous chondrocyte transplantation. Clin Orthop Relat Res 433:233–242PubMed Vasara AI, Nieminen MT, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I (2005) Indentation stiffness of repair tissue after autologous chondrocyte transplantation. Clin Orthop Relat Res 433:233–242PubMed
139.
Zurück zum Zitat Visna P, Pasa L, Cizmár I, Hart R, Hoch J (2004) Treatment of deep cartilage defects of the knee using autologous chondrograft transplantation and by abrasive techniques—a randomized controlled study. Acta Chir Belg 104:709–714PubMed Visna P, Pasa L, Cizmár I, Hart R, Hoch J (2004) Treatment of deep cartilage defects of the knee using autologous chondrograft transplantation and by abrasive techniques—a randomized controlled study. Acta Chir Belg 104:709–714PubMed
140.
Zurück zum Zitat Visna P, Pasa L, Hart R, Kocis J, Cizmár I, Adler J (2003) Treatment of deep chondral defects of the knee using autologous chondrocytes cultured on a support—results after one year. Acta Chir Orthop Traumatol Cech 70:356–362PubMed Visna P, Pasa L, Hart R, Kocis J, Cizmár I, Adler J (2003) Treatment of deep chondral defects of the knee using autologous chondrocytes cultured on a support—results after one year. Acta Chir Orthop Traumatol Cech 70:356–362PubMed
141.
Zurück zum Zitat Visna P, Adler J, Pasa L, Kocis J, Cizmar I, Horky D (2003) Autologous chondrocyte transplantation for the treatment of articular defects of the knee. Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae 76:241–250 Visna P, Adler J, Pasa L, Kocis J, Cizmar I, Horky D (2003) Autologous chondrocyte transplantation for the treatment of articular defects of the knee. Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae 76:241–250
142.
Zurück zum Zitat Wada Y, Watanabe A, Yamashita T, Isobe T, Moriya H (2003) Evaluation of articular cartilage with 3D-SPGR MRI after autologous chondrocyte implantation. J Orthop Sci 8:514–517PubMed Wada Y, Watanabe A, Yamashita T, Isobe T, Moriya H (2003) Evaluation of articular cartilage with 3D-SPGR MRI after autologous chondrocyte implantation. J Orthop Sci 8:514–517PubMed
143.
Zurück zum Zitat Wang CJ (2002) Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral graftsA 2- to 4-year follow-up study. Arch Orthop Trauma Surg 122:169–172PubMed Wang CJ (2002) Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral graftsA 2- to 4-year follow-up study. Arch Orthop Trauma Surg 122:169–172PubMed
144.
Zurück zum Zitat Williams RJ 3rd, Harnly HW (2007) Microfracture: indications, technique, and results. Instr Course Lect 56:419–428PubMed Williams RJ 3rd, Harnly HW (2007) Microfracture: indications, technique, and results. Instr Course Lect 56:419–428PubMed
145.
Zurück zum Zitat Yates JW Jr (2003) The effectiveness of autologous chondrocyte implantation for treatment of full-thickness articular cartilage lesions in workers’ compensation patients. Orthopedics 26:295–300PubMed Yates JW Jr (2003) The effectiveness of autologous chondrocyte implantation for treatment of full-thickness articular cartilage lesions in workers’ compensation patients. Orthopedics 26:295–300PubMed
146.
Zurück zum Zitat Zheng MH, Willers C, Kirilak L, Yates P, Xu J, Wood D, Shimmin A (2007) Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment. Tissue Eng 13:737–746PubMed Zheng MH, Willers C, Kirilak L, Yates P, Xu J, Wood D, Shimmin A (2007) Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment. Tissue Eng 13:737–746PubMed
Metadaten
Titel
We do not have evidence based methods for the treatment of cartilage defects in the knee
verfasst von
Jan P. Benthien
Manuela Schwaninger
Peter Behrens
Publikationsdatum
01.04.2011
Verlag
Springer-Verlag
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 4/2011
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-010-1271-5

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