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Knee Surgery, Sports Traumatology, Arthroscopy

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01.12.2011 | Knee

Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial

verfasst von: Nikica Darabos, Miroslav Haspl, Carsten Moser, Anela Darabos, Dubravka Bartolek, Dietrich Groenemeyer

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Sonderheft 1/2011

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Abstract

Purpose

Pro-inflammatory cytokines play a pivotal role in osteoarthritis, as well as in bone tunnel widening after ACL reconstructive surgery. A new treatment option is to administer autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and growth factors (IGF-1, PDGF, and TGF-β1, among others) in the liquid blood phase. The purpose of this trial was to establish whether the postoperative outcome could be affected by intraarticular application of ACS.

Methods

In a prospective, randomized, double-blinded, placebo-controlled trial with two parallel groups, 62 patients were treated. Bone tunnel width was measured by CT scans, while clinical efficacy was assessed by patient-administered outcome instruments (WOMAC, IKDC 2000) up to 1 year following the ACL reconstruction in patients receiving either ACS (Group A) or placebo (Group B). We compared the levels and dynamics of IL-1β concentrations in the synovial liquid and examined the correlation between the levels of IL-1β at three different postoperative points.

Results

Bone tunnel enlargement was significantly less (6 months: 8%, 12 months: 13%) in Group A than in Group B (6 months: 31%, 12 months: 38%). Clinical outcomes (WOMAC, IKDC 2000) were consistently better in patients treated with ACS at all data points and for all outcome parameters, and there were statistically significant differences in the WOMAC stiffness subscale after 1 year. The decrease in IL-1β synovial fluid concentration was more pronounced in the ACS group, and values were lower, to a statistically significant degree, in the ACS group at day 10.

Conclusion

The intraarticular administration/injection of ACS results in decreased bone tunnel widening after ACL reconstructive surgery.

Level of evidence

Therapeutic study, Randomized controlled trial (significant differences and narrow confidence intervals), Level I.

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Titel: Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial
verfasst von: Nikica Darabos
Miroslav Haspl
Carsten Moser
Anela Darabos
Dubravka Bartolek
Dietrich Groenemeyer
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe Sonderheft 1/2011
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-011-1458-4

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Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial

Abstract

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Methods

Results

Conclusion

Level of evidence

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