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Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 7/2013

01.07.2013 | Sports Medicine

Histological scoring systems for tissue-engineered, ex vivo and degenerative meniscus

verfasst von: Umile Giuseppe Longo, Mattia Loppini, Giovanni Romeo, Nicola Maffulli, Vincenzo Denaro

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 7/2013

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Abstract

Purpose

Because its function is strictly related to the quality of meniscal tissue, one of the most important outcome measures for the evaluation of meniscal repair effectiveness is the assessment of histological features. Data on the validation and application of the histological scoring systems in research settings and specific fields of meniscal disorders are lacking. The available histological scoring systems to assess meniscal tissue were systematically evaluated.

Methods

Histological scoring systems for the analysis of degenerative meniscal changes, ex vivo and tissue-engineered meniscal repair were reviewed. Furthermore, the validity and applicability of the scoring systems were assessed.

Results

The Copenhaver classification and Mankin score have been modified to classify the degeneration of collagen bundles in the meniscal structure. The Pauli score seems to be a comprehensive and simple scoring system for the evaluation of both macroscopic and histologic meniscal changes related to ageing and osteoarthritic degeneration. The Zhang score may be used for ex vivo gene therapy in meniscus healing. The Ishida score seems to be the most adequate for the evaluation of tissue-engineered meniscal repair.

Conclusion

Although several histological scoring systems are available to assess meniscal structure, only few of them have been validated for specific application in research settings. Validated scores are required to provide a standardized data collection to allow the comparison of results of different research groups. Further experimental and clinical studies are needed to find a comprehensive and validated histological scoring system in the field of meniscus repair.

Level of evidence

Systematic review of Level III studies, Level III.
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Metadaten
Titel
Histological scoring systems for tissue-engineered, ex vivo and degenerative meniscus
verfasst von
Umile Giuseppe Longo
Mattia Loppini
Giovanni Romeo
Nicola Maffulli
Vincenzo Denaro
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 7/2013
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-012-2142-z

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