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Erschienen in: International Urogynecology Journal 1/2009

01.01.2009 | Original Article

Do preoperative cytokine levels offer a prognostic factor for polypropylene mesh erosion after suburethral sling surgery for stress urinary incontinence?

verfasst von: Tomasz Rechberger, Katarzyna Jankiewicz, Aneta Adamiak, Paweł Miotla, Agnieszka Chrobak, Małgorzata Jerzak

Erschienen in: International Urogynecology Journal | Ausgabe 1/2009

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Abstract

When polypropylene meshes are used in reconstructive urogynecological surgery, the erosion rates vary from 3.3% to 14% and causative factors for such erosions are still unknown in many cases. Therefore, the aim of our study was to establish the role of immunologic factors in the process of polypropylene tapes erosions after suburethral sling procedures. Serum concentrations of tumor necrosis factor α, interleukin (IL)-2, IL-4, IL-5, IL-10, and interferon (IFN)-γ were estimated in 123 patients suffering from stress urinary incontinence preoperatively and during 12 months follow-up using Human Th1/Th2 Cytokine Cytometric Bead Array I kit. The same immunological assessment was performed in each case of detected tape erosion. Statistical calculation was performed using UNIVARIATE, CORR, and NPAR1WAY procedures from Statistical Analysis System. The unpaired Student’s t test, nonparametric Mann–Whitney U test, and Wilcoxon tests were used. Preoperative IFN-γ concentration was significantly higher in women with subsequent polypropylene mesh erosion when compared to women with successful outcome (p < 0.05). Th1 cytokine profile may be related to the risk of the vaginal erosions following placement of polypropylene meshes. The way to lower erosion rate may involve exclusion of the patients immunologically prone to synthetic material erosion. The factor which can help to select such patients could be preoperative level of IFN-γ.
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Metadaten
Titel
Do preoperative cytokine levels offer a prognostic factor for polypropylene mesh erosion after suburethral sling surgery for stress urinary incontinence?
verfasst von
Tomasz Rechberger
Katarzyna Jankiewicz
Aneta Adamiak
Paweł Miotla
Agnieszka Chrobak
Małgorzata Jerzak
Publikationsdatum
01.01.2009
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 1/2009
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-008-0731-7

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