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Erschienen in: Osteoporosis International 11/2005

01.11.2005 | Original Article

Bone mineral density and osteoporosis among a predominantly Caucasian elderly population in the city of São Paulo, Brazil

verfasst von: Marilia Brasilio Rodrigues Camargo, Maysa Seabra Cendoroglo, Luiz Roberto Ramos, Maria do Rosario Dias de Oliveira Latorre, Gabriela Luporini Saraiva, Andrea Lage, Nelson Carvalhaes Neto, Lara Miguel Quirino Araújo, José Gilberto H. Vieira, Marise Lazaretti-Castro

Erschienen in: Osteoporosis International | Ausgabe 11/2005

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Abstract

This cross-sectional study covered 301 individuals over 70 years of age—207 women (W) and 94 men (M)—living in the city of São Paulo, Brazil. Our aims were to evaluate the prevalence of low bone mineral density (BMD) in this population and the possible factors that influence BMD. The subjects were submitted to a bone densitometry scan (DXA) to evaluate the BMD at lumbar spine (LS), femoral neck (FN), trochanter (T), total femur (TF) and total body composition. At the time, the participants filled in a questionnaire about lifestyle habits, diet and medical history, as well as having blood samples taken to check hormone and biochemical levels. Anthropometric parameters were measured. Osteopenia and osteoporosis were defined in accordance with the criteria suggested by the World Health Organization. In the different sites studied, the prevalence of osteopenia and osteoporosis varied, in men ranging 33.3–57.4% and 6.4–16.1%, respectively, and in women ranging 36.6–56.5% and 22.2–33.2%, respectively. Weight was the variable that most strongly correlated with BMD at the proximal femur in both sexes (men, r =0.44–0.52; women, r =0.48–0.52) and with BMD at LS in women ( r =0.44). Height was the parameter that best correlated with BMD at LS in men ( r =0.34). In men follicle-stimulating hormone, growth hormone and glycemia correlated with BMD at T and TF, while plasma albumin only correlated with BMD at T. In women glycemia correlated with BMD at LS, and follicle-stimulating hormone correlated with BMD at FN, T and TF. In conclusion, we found a high prevalence of osteopenia and osteoporosis in this population, with weight being the best predictor of BMD. The prevalence of osteoporosis and osteopenia at FN was as high in men as that observed in women.
Literatur
1.
Zurück zum Zitat Kanis JA, Glüer CC (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202CrossRefPubMed Kanis JA, Glüer CC (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202CrossRefPubMed
2.
Zurück zum Zitat Ross PD (1996) Osteoporosis: frequency, consequences, and risk factors. Arch Intern Med 156:1399–1411 Ross PD (1996) Osteoporosis: frequency, consequences, and risk factors. Arch Intern Med 156:1399–1411
3.
Zurück zum Zitat Eastell R (1999) Bone density can be used to assess fracture risk [comment]. BMJ 318:864–865 Eastell R (1999) Bone density can be used to assess fracture risk [comment]. BMJ 318:864–865
4.
Zurück zum Zitat Hawker GA (1996) The epidemiology of osteoporosis. J Rheumatol 23 [Suppl 45]: 2–5 Hawker GA (1996) The epidemiology of osteoporosis. J Rheumatol 23 [Suppl 45]: 2–5
5.
Zurück zum Zitat Ramos LR, Toniolo J, Cendoroglo MS et al (1998) Two-year follow-up study of elderly residents in S. Paulo, Brazil: methodology and preliminary results. Rev Saude Publica 32 (5): 397–407 Ramos LR, Toniolo J, Cendoroglo MS et al (1998) Two-year follow-up study of elderly residents in S. Paulo, Brazil: methodology and preliminary results. Rev Saude Publica 32 (5): 397–407
6.
Zurück zum Zitat Wark JD (1999) Osteoporosis: a global perspective. Bull World Health Organ 77(5): 424–426 Wark JD (1999) Osteoporosis: a global perspective. Bull World Health Organ 77(5): 424–426
7.
Zurück zum Zitat Viana PRS (1999) Avaliação da densidade mineral óssea e da ocorrência de fratura vertebral em pacientes com lupus eritematoso sistêmico [master thesis]. Federal University of São Paulo, São Paulo, Brazil, p 18 Viana PRS (1999) Avaliação da densidade mineral óssea e da ocorrência de fratura vertebral em pacientes com lupus eritematoso sistêmico [master thesis]. Federal University of São Paulo, São Paulo, Brazil, p 18
8.
Zurück zum Zitat Kelly TL (1990) Bone mineral density reference databases for American men and women. J Bone Miner Res 5 [Suppl 2]:S249 Kelly TL (1990) Bone mineral density reference databases for American men and women. J Bone Miner Res 5 [Suppl 2]:S249
9.
Zurück zum Zitat Looker AC, Wahner HW, Dunn WL et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489CrossRefPubMed Looker AC, Wahner HW, Dunn WL et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489CrossRefPubMed
10.
Zurück zum Zitat Tenenhouse A, Joseph L, Kreiger N et al (2000) Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 11:897–904CrossRefPubMed Tenenhouse A, Joseph L, Kreiger N et al (2000) Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 11:897–904CrossRefPubMed
11.
Zurück zum Zitat VanItallie TB, Mei-Uih Y, Heymsfield SB et al (1990) Height-normalized indices of body’s fat-free mass and fat mass: potentially useful indicators of nutritional status. Am J Clin Nutr 52:953–959 VanItallie TB, Mei-Uih Y, Heymsfield SB et al (1990) Height-normalized indices of body’s fat-free mass and fat mass: potentially useful indicators of nutritional status. Am J Clin Nutr 52:953–959
12.
Zurück zum Zitat Vieira JGH, Lombardi MT, Nishida SK (1990) Monoclonal antibody-based immunoenzymometric assay for serum human growth hormone. Braz J Med Biol Res 23:293–296 Vieira JGH, Lombardi MT, Nishida SK (1990) Monoclonal antibody-based immunoenzymometric assay for serum human growth hormone. Braz J Med Biol Res 23:293–296
13.
Zurück zum Zitat Vieira JGH, Nishida SK, Lombardi MT et al (1990) Desenvolvimento de ensaio imunoenzimométrico em anticorpos monoclonais para a dosagem de hormônio luteotrófico (LH) no soro. Rev Bras Pat Clin 26(3):84–87 Vieira JGH, Nishida SK, Lombardi MT et al (1990) Desenvolvimento de ensaio imunoenzimométrico em anticorpos monoclonais para a dosagem de hormônio luteotrófico (LH) no soro. Rev Bras Pat Clin 26(3):84–87
14.
Zurück zum Zitat Vieira JGH, Furlanetto RP, Russo EMK et al (1980) Radioimunoensaio do sulfato de deidroepiandrosterona: metodologia e padronização de valores normais. Arq Bras Endocrinol Metabol 24(2):79–83 Vieira JGH, Furlanetto RP, Russo EMK et al (1980) Radioimunoensaio do sulfato de deidroepiandrosterona: metodologia e padronização de valores normais. Arq Bras Endocrinol Metabol 24(2):79–83
15.
Zurück zum Zitat Vieira JGH, Kunii IS, Nishida SK et al (1992) Desenvolvimento e aplicação de um método imunofluorométrico para a dosagem de tirotrofina humana (TSH) no soro e em sangue total colhido em papel de filtro. Arq Bras Endocrinol Metabol 36(1):7–12 Vieira JGH, Kunii IS, Nishida SK et al (1992) Desenvolvimento e aplicação de um método imunofluorométrico para a dosagem de tirotrofina humana (TSH) no soro e em sangue total colhido em papel de filtro. Arq Bras Endocrinol Metabol 36(1):7–12
16.
Zurück zum Zitat Vieira JGH, Nishida SK, Lombardi MT et al (1994) Emprego de anticorpos monoclonais no desenvolvimento de um ensaio imunofluorométrico de alta sensibilidade para a dosagem de FSH. Estudo dos níveis séricos em meninos normais nos diferentes estádios puberais. Arq Bras Endocrinol Metabol 38(2):76–81 Vieira JGH, Nishida SK, Lombardi MT et al (1994) Emprego de anticorpos monoclonais no desenvolvimento de um ensaio imunofluorométrico de alta sensibilidade para a dosagem de FSH. Estudo dos níveis séricos em meninos normais nos diferentes estádios puberais. Arq Bras Endocrinol Metabol 38(2):76–81
17.
Zurück zum Zitat Wheeler MJ, D’Souza A, Matadeen J et al (1996) Ciba Corning ACS: 189 testosterone assay evaluated. Clin Chem 42:1445–1449 Wheeler MJ, D’Souza A, Matadeen J et al (1996) Ciba Corning ACS: 189 testosterone assay evaluated. Clin Chem 42:1445–1449
18.
Zurück zum Zitat Looker AC, Orwoll ES, Johnston CC et al (1997) Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 12(11):1761–1768PubMed Looker AC, Orwoll ES, Johnston CC et al (1997) Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 12(11):1761–1768PubMed
19.
Zurück zum Zitat IBGE: Instituto Brasileiro de Geografia e Estatística (2000) Censo demográfico 2000. Available from: http://www.ibge.gov.br/ibgeteen/noticias/brasileirosvivemmais.html IBGE: Instituto Brasileiro de Geografia e Estatística (2000) Censo demográfico 2000. Available from: http://​www.​ibge.​gov.​br/​ibgeteen/​noticias/​brasileirosvivem​mais.​html
20.
Zurück zum Zitat Ramos LR, Rosa TEC, Oliveira ZM, Medina MCG (1993) Perfil do idoso em área metropolitana na região sudeste do Brasil: resultados de inquérito domiciliar. Rev Saude Publica 27(2):87–94 Ramos LR, Rosa TEC, Oliveira ZM, Medina MCG (1993) Perfil do idoso em área metropolitana na região sudeste do Brasil: resultados de inquérito domiciliar. Rev Saude Publica 27(2):87–94
21.
Zurück zum Zitat Szejnfeld VL, Atra E, Baracat EC et al (1995) Bone density in white Brazilian women: rapid loss at the time around the menopause. Calcif Tissue Int 56(3):186–191 Szejnfeld VL, Atra E, Baracat EC et al (1995) Bone density in white Brazilian women: rapid loss at the time around the menopause. Calcif Tissue Int 56(3):186–191
22.
Zurück zum Zitat Castro da Rocha FA, Ribeiro AR (2003) Low incidence of hip fractures in an equatorial area. Osteoporos Int 14(6):496–499 Castro da Rocha FA, Ribeiro AR (2003) Low incidence of hip fractures in an equatorial area. Osteoporos Int 14(6):496–499
24.
Zurück zum Zitat Yang S, Taxel P (2002) Osteoporosis in older men: an emerging clinical problem. Clin Geriatrics 10(8):28–37 Yang S, Taxel P (2002) Osteoporosis in older men: an emerging clinical problem. Clin Geriatrics 10(8):28–37
25.
Zurück zum Zitat Zerbini CAF, Latorre MRO, Jaime PC et al (2000) Bone mineral density in Brazilian men 50 years and older. Braz J Med Biol Res 33(12):1429–1435 Zerbini CAF, Latorre MRO, Jaime PC et al (2000) Bone mineral density in Brazilian men 50 years and older. Braz J Med Biol Res 33(12):1429–1435
26.
Zurück zum Zitat Blunt BA, Klauber MR, Barret-Connor EL et al (1994) Sex differences in bone mineral density in 1,653 men and women in the sixth through tenth decades of life: the Rancho Bernardo study. J Bone Miner Res 9(9):1333–1338PubMed Blunt BA, Klauber MR, Barret-Connor EL et al (1994) Sex differences in bone mineral density in 1,653 men and women in the sixth through tenth decades of life: the Rancho Bernardo study. J Bone Miner Res 9(9):1333–1338PubMed
27.
Zurück zum Zitat Orwoll ES, Oviatt SK, Mann T (1990) The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70(4):1202–1207PubMed Orwoll ES, Oviatt SK, Mann T (1990) The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70(4):1202–1207PubMed
28.
Zurück zum Zitat Jones G, White C, Nguyen T, Sambrook PN, Kelly PJ, Eisman JA (1996) Prevalent vertebral deformities: relationship to bone mineral density and spinal osteophytosis in elderly men and women. Osteoporos Int 6(3):233–239PubMed Jones G, White C, Nguyen T, Sambrook PN, Kelly PJ, Eisman JA (1996) Prevalent vertebral deformities: relationship to bone mineral density and spinal osteophytosis in elderly men and women. Osteoporos Int 6(3):233–239PubMed
29.
Zurück zum Zitat Hannan MT, Felson DT, Dawson-Hughes B et al (2000) Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15(4):710–720PubMed Hannan MT, Felson DT, Dawson-Hughes B et al (2000) Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15(4):710–720PubMed
30.
Zurück zum Zitat Khosla S, Melton LJ III, Riggs BL (2002) Estrogen and the male skeleton. J Clin Endocrinol Metab 87(4):1443–1450CrossRefPubMed Khosla S, Melton LJ III, Riggs BL (2002) Estrogen and the male skeleton. J Clin Endocrinol Metab 87(4):1443–1450CrossRefPubMed
31.
Zurück zum Zitat Hui SL, Perkins AJ, Zhou L et al (2002) Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levels. J Clin Endocrinol Metab 87(4):1539–1543CrossRefPubMed Hui SL, Perkins AJ, Zhou L et al (2002) Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levels. J Clin Endocrinol Metab 87(4):1539–1543CrossRefPubMed
32.
Zurück zum Zitat Riggs BL, Khosla S, Melton LJ III (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23(3):279–302CrossRefPubMed Riggs BL, Khosla S, Melton LJ III (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23(3):279–302CrossRefPubMed
33.
Zurück zum Zitat Harman SM, Metter EJ, Tobin JD et al (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Encocrinol Metab 86(2):724–731 Harman SM, Metter EJ, Tobin JD et al (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Encocrinol Metab 86(2):724–731
34.
Zurück zum Zitat Seeman E (1999) Osteoporosis in men. Osteoporos Int [Suppl 2]:S97–S110 Seeman E (1999) Osteoporosis in men. Osteoporos Int [Suppl 2]:S97–S110
35.
Zurück zum Zitat Greendale GA, Edelstein S, Barrett-Connor E (1997) Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 12(11):1833–1843PubMed Greendale GA, Edelstein S, Barrett-Connor E (1997) Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 12(11):1833–1843PubMed
36.
Zurück zum Zitat Rudman D, Drinka PJ, Wilson CR et al (1994) Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol (Oxf) 40(5):653–661 Rudman D, Drinka PJ, Wilson CR et al (1994) Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol (Oxf) 40(5):653–661
37.
Zurück zum Zitat Center JR, Nguyen TV, Sambrook PN, Eisman JA (1999) Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 84(10):3626–3635CrossRefPubMed Center JR, Nguyen TV, Sambrook PN, Eisman JA (1999) Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 84(10):3626–3635CrossRefPubMed
38.
Zurück zum Zitat Martínez Díaz-Guerra G, Hawkins F, Rapado A, Ruiz Díaz MA, Díaz-Curiel M (2001) Hormonal and anthropometric predictors of bone mass in healthy elderly men: major effect of sex hormone binding globulin, parathyroid hormone and body weight. Osteoporos Int 12:178–184 Martínez Díaz-Guerra G, Hawkins F, Rapado A, Ruiz Díaz MA, Díaz-Curiel M (2001) Hormonal and anthropometric predictors of bone mass in healthy elderly men: major effect of sex hormone binding globulin, parathyroid hormone and body weight. Osteoporos Int 12:178–184
39.
Zurück zum Zitat Smerdely P, Seller M, Smith A et al (2000) Predictors of bone mass in healthy older men in the community. Med J Aust 173:183–186 Smerdely P, Seller M, Smith A et al (2000) Predictors of bone mass in healthy older men in the community. Med J Aust 173:183–186
40.
Zurück zum Zitat Khosla S, Melton LJ III, Atkinson EJ et al (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83(7):2266–2274CrossRefPubMed Khosla S, Melton LJ III, Atkinson EJ et al (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83(7):2266–2274CrossRefPubMed
41.
Zurück zum Zitat Edelstein SL, Barrett-Connor E (1993) Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol 138(3):160–169 Edelstein SL, Barrett-Connor E (1993) Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol 138(3):160–169
42.
Zurück zum Zitat Reid IR (2002) Relationships among body mass, its components, and bone. Bone 31 (5): 547–555CrossRefPubMed Reid IR (2002) Relationships among body mass, its components, and bone. Bone 31 (5): 547–555CrossRefPubMed
Metadaten
Titel
Bone mineral density and osteoporosis among a predominantly Caucasian elderly population in the city of São Paulo, Brazil
verfasst von
Marilia Brasilio Rodrigues Camargo
Maysa Seabra Cendoroglo
Luiz Roberto Ramos
Maria do Rosario Dias de Oliveira Latorre
Gabriela Luporini Saraiva
Andrea Lage
Nelson Carvalhaes Neto
Lara Miguel Quirino Araújo
José Gilberto H. Vieira
Marise Lazaretti-Castro
Publikationsdatum
01.11.2005
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 11/2005
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-004-1831-y

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