Skip to main content
Erschienen in: Osteoporosis International 3/2007

01.03.2007 | Original Article

Bone density in relation to alcohol intake among men and women in the United States

verfasst von: K. S. Wosje, H. J. Kalkwarf

Erschienen in: Osteoporosis International | Ausgabe 3/2007

Einloggen, um Zugang zu erhalten

Abstract

Summary

Studies of postmenopausal women have shown a positive association between BMD and alcohol intake. We found that BMD was higher in men, and possibly postmenopausal women, who drank alcohol compared with those who abstained. Drinking alcohol, but not binge drinking, may benefit bone health of men and postmenopausal women.

Introduction

Osteoporotic fractures account for over 2.5 million physician visits annually for persons ages ≥45 years in the United States. Studies of postmenopausal women show a positive association between bone mineral density (BMD) and alcohol intake, but for men and premenopausal women, the bone–alcohol relationship remains unclear. We examined the association between total hip (TH) and femoral neck (FN) BMD and alcohol intake of men and pre- and postmenopausal women.

Methods

We conducted multiple regression analyses using data from 13,512 persons ages ≥20 years from the Third National Health and Nutrition Examination Survey, 1988–1994. Alcohol intake and binge drinking were measured by questionnaire and hip BMD by dual energy X-ray absorptiometry (DXA).

Results

Accounting for covariates, TH BMD was higher in men (n = 6,868) who had 5–29 (+2.1%, p < 0.01) and >29 drinking occasions/month (+1.7%, p < 0.05) than men who abstained. BMD of premenopausal women (n = 4,136) who drank alcohol did not differ from those who abstained. FN BMD was 3.8% higher in postmenopausal women (n = 2,043) who had >29 drinking occasions/month than those who abstained (p = 0.06). Binge drinking was not associated with BMD of men or women.

Conclusions

Drinking alcohol, but not binge drinking, appears to be beneficial to bone health of men and possibly postmenopausal women.
Literatur
1.
Zurück zum Zitat U.S. Department of Health and Human Services (2004) Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Rockville U.S. Department of Health and Human Services (2004) Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Rockville
2.
Zurück zum Zitat Ray NF, Chan JK, Thamer M et al (1997) Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 12:24–34PubMedCrossRef Ray NF, Chan JK, Thamer M et al (1997) Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 12:24–34PubMedCrossRef
3.
Zurück zum Zitat Magaziner J, Hawkes W, Hebel JR et al (2000) Recovery from hip fracture in eight areas of function. J Gerontol, Ser A, Biol Sci Med Sci 55:M498–M507 Magaziner J, Hawkes W, Hebel JR et al (2000) Recovery from hip fracture in eight areas of function. J Gerontol, Ser A, Biol Sci Med Sci 55:M498–M507
4.
Zurück zum Zitat Kim MJ, Shim MS, Kim MK et al (2003) Effect of chronic alcohol ingestion on bone mineral density in males without liver cirrhosis. Korean J Intern Med 18:174–180PubMed Kim MJ, Shim MS, Kim MK et al (2003) Effect of chronic alcohol ingestion on bone mineral density in males without liver cirrhosis. Korean J Intern Med 18:174–180PubMed
5.
Zurück zum Zitat Diez A, Puig J, Serrano S et al (1994) Alcohol-induced bone disease in the absence of severe chronic liver damage. J Bone Miner Res 9:825–831PubMed Diez A, Puig J, Serrano S et al (1994) Alcohol-induced bone disease in the absence of severe chronic liver damage. J Bone Miner Res 9:825–831PubMed
6.
Zurück zum Zitat Crilly RG, Anderson C, Hogan D et al (1988) Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif Tissue Int 43:269–276PubMedCrossRef Crilly RG, Anderson C, Hogan D et al (1988) Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif Tissue Int 43:269–276PubMedCrossRef
7.
Zurück zum Zitat Schnitzler CM, Solomon L (1984) Bone changes after alcohol abuse. S Afr Med J 66:730–734PubMed Schnitzler CM, Solomon L (1984) Bone changes after alcohol abuse. S Afr Med J 66:730–734PubMed
8.
Zurück zum Zitat Ganry O, Baudoin C, Fardellone P (2000) Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS study. Am J Epidemiol 15:773–780 Ganry O, Baudoin C, Fardellone P (2000) Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS study. Am J Epidemiol 15:773–780
9.
Zurück zum Zitat Holbrook TL, Barrett-Connor E (1993) A prospective study of alcohol consumption and bone mineral density. Br Med J 306:1506–1509 Holbrook TL, Barrett-Connor E (1993) A prospective study of alcohol consumption and bone mineral density. Br Med J 306:1506–1509
10.
Zurück zum Zitat Laitinen K, Valimaki M, Keto P (1991) Bone mineral density measured by dual-energy x-ray absorptiometry in healthy Finnish women. Calcif Tissue Int 48:224–231PubMedCrossRef Laitinen K, Valimaki M, Keto P (1991) Bone mineral density measured by dual-energy x-ray absorptiometry in healthy Finnish women. Calcif Tissue Int 48:224–231PubMedCrossRef
11.
Zurück zum Zitat New SA, Robins SP, Campbell MK et al (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71:142–151PubMed New SA, Robins SP, Campbell MK et al (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71:142–151PubMed
12.
Zurück zum Zitat Feskanich D, Korrick SA, Greenspan SL et al (1999) Moderate alcohol consumption and bone density among postmenopausal women. J Women's Health 8:65–73CrossRef Feskanich D, Korrick SA, Greenspan SL et al (1999) Moderate alcohol consumption and bone density among postmenopausal women. J Women's Health 8:65–73CrossRef
13.
Zurück zum Zitat Felson DT, Zhang Y, Hannan MT et al (1995) Alcohol intake and bone mineral density in elderly men and women. The Framingham study. Am J Epidemiol 142:485–492PubMed Felson DT, Zhang Y, Hannan MT et al (1995) Alcohol intake and bone mineral density in elderly men and women. The Framingham study. Am J Epidemiol 142:485–492PubMed
14.
Zurück zum Zitat Hansen MA, Overgaard K, Riis BJ et al (1991) Potential risk factors for development of postmenopausal osteoporosis - examined over a 12-year period. Osteoporos Int 1:95–102PubMedCrossRef Hansen MA, Overgaard K, Riis BJ et al (1991) Potential risk factors for development of postmenopausal osteoporosis - examined over a 12-year period. Osteoporos Int 1:95–102PubMedCrossRef
15.
Zurück zum Zitat Rapuri PB, Gallagher JC, Balhorn KE et al (2000) Alcohol intake and bone metabolism in elderly women. Am J Clin Nutr 72:1206–1213PubMed Rapuri PB, Gallagher JC, Balhorn KE et al (2000) Alcohol intake and bone metabolism in elderly women. Am J Clin Nutr 72:1206–1213PubMed
16.
Zurück zum Zitat Bauer DC, Browner WS, Cauley JA et al (1993) Factors associated with appendicular bone mass in older women. Ann Intern Med 118:665–667 Bauer DC, Browner WS, Cauley JA et al (1993) Factors associated with appendicular bone mass in older women. Ann Intern Med 118:665–667
17.
Zurück zum Zitat MacInnis RJ, Cassar C, Nowson CA et al (2003) Determinants of bone density in 30- to 65-year-old women: a co-twin study. J Bone Miner Res 18:1650–1656PubMedCrossRef MacInnis RJ, Cassar C, Nowson CA et al (2003) Determinants of bone density in 30- to 65-year-old women: a co-twin study. J Bone Miner Res 18:1650–1656PubMedCrossRef
18.
Zurück zum Zitat Angus RM, Sambrook PN, Pocock NA et al (1988) Dietary intake and bone mineral density. Bone Miner 4:265–277PubMed Angus RM, Sambrook PN, Pocock NA et al (1988) Dietary intake and bone mineral density. Bone Miner 4:265–277PubMed
19.
Zurück zum Zitat Stevenson JC, Lees B, Devenport M et al (1989) Determinants of bone density in normal women: risk factors for future osteoporosis? Br Med J 298:924–928CrossRef Stevenson JC, Lees B, Devenport M et al (1989) Determinants of bone density in normal women: risk factors for future osteoporosis? Br Med J 298:924–928CrossRef
20.
Zurück zum Zitat Grainge MJ, Coupland, CAC, Cliffe SJ et al (1998) Cigarette smoking, alcohol and caffeine consumption, and bone mineral density in postmenopausal women. Osteoporos Int 8:355–363PubMedCrossRef Grainge MJ, Coupland, CAC, Cliffe SJ et al (1998) Cigarette smoking, alcohol and caffeine consumption, and bone mineral density in postmenopausal women. Osteoporos Int 8:355–363PubMedCrossRef
21.
Zurück zum Zitat Bainbridge KE, Sowers M, Lin X et al (2004) Risk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women. Osteoporos Int 15:439–446PubMedCrossRef Bainbridge KE, Sowers M, Lin X et al (2004) Risk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women. Osteoporos Int 15:439–446PubMedCrossRef
22.
Zurück zum Zitat New SA, Bolton-Smith C, Grubb DA et al (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 65:1831–1839PubMed New SA, Bolton-Smith C, Grubb DA et al (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 65:1831–1839PubMed
23.
Zurück zum Zitat Kroger H, Tuppurainen M, Honkanen R et al (1994) Bone mineral density and risk factors for osteoporosis-a population-based study of 1600 perimenopausal women. Calcif Tissue Int 55:1–7PubMedCrossRef Kroger H, Tuppurainen M, Honkanen R et al (1994) Bone mineral density and risk factors for osteoporosis-a population-based study of 1600 perimenopausal women. Calcif Tissue Int 55:1–7PubMedCrossRef
24.
Zurück zum Zitat Macdonald HM, New SA, Golden MHN et al (2004) Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79:155–165PubMed Macdonald HM, New SA, Golden MHN et al (2004) Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79:155–165PubMed
26.
Zurück zum Zitat Gavaler JS, Love K, Van Thiel D et al (1991) An international study of the relationship between alcohol consumption and postmenopausal estradiol levels. Alcohol Alcohol, (Suppl 1):327–330 Gavaler JS, Love K, Van Thiel D et al (1991) An international study of the relationship between alcohol consumption and postmenopausal estradiol levels. Alcohol Alcohol, (Suppl 1):327–330
27.
Zurück zum Zitat Hankinson SE, Willett WC, Manson JE et al (1995) Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst 87:1297–1302PubMedCrossRef Hankinson SE, Willett WC, Manson JE et al (1995) Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst 87:1297–1302PubMedCrossRef
28.
Zurück zum Zitat Onland-Moret NC, Peeters, PHM, van der Schouw YT et al (2005) Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study. J Clin Endocrinol Metab 90:1414–1419PubMedCrossRef Onland-Moret NC, Peeters, PHM, van der Schouw YT et al (2005) Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study. J Clin Endocrinol Metab 90:1414–1419PubMedCrossRef
29.
Zurück zum Zitat Dorgan JF, Reichman ME, Judd JT et al (1994) The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States). Cancer Causes Control 5:53–60PubMedCrossRef Dorgan JF, Reichman ME, Judd JT et al (1994) The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States). Cancer Causes Control 5:53–60PubMedCrossRef
30.
Zurück zum Zitat (1994) Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–94. National Center for Health Statistics, Hyattsville (1994) Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–94. National Center for Health Statistics, Hyattsville
31.
Zurück zum Zitat Wahner HW, Looker AC, Dunn WL et al (1994) Quality control of bone densitometry in a national health survey (NHANES III) using three mobile examination centers. J Bone Miner Res 9:951–960PubMedCrossRef Wahner HW, Looker AC, Dunn WL et al (1994) Quality control of bone densitometry in a national health survey (NHANES III) using three mobile examination centers. J Bone Miner Res 9:951–960PubMedCrossRef
32.
Zurück zum Zitat Kalkwarf HJ, Khoury JC, Lanphear BP (2003) Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin Nutr 77:257–265PubMed Kalkwarf HJ, Khoury JC, Lanphear BP (2003) Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin Nutr 77:257–265PubMed
33.
Zurück zum Zitat Benson BW, Shulman JD (2005) Inclusion of tobacco exposure as a predictive factor for decreased bone mineral content. Nicotine Tob Res 7:719–724PubMedCrossRef Benson BW, Shulman JD (2005) Inclusion of tobacco exposure as a predictive factor for decreased bone mineral content. Nicotine Tob Res 7:719–724PubMedCrossRef
34.
Zurück zum Zitat Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York
35.
Zurück zum Zitat Knoke JD, Barrett-Connor E (2003) Weight loss: a determinant of hip bone loss in older men and women. Am J Epidemiol 158:1132–1138PubMedCrossRef Knoke JD, Barrett-Connor E (2003) Weight loss: a determinant of hip bone loss in older men and women. Am J Epidemiol 158:1132–1138PubMedCrossRef
36.
Zurück zum Zitat Williams FMK, Cherkas LF, Spector TD et al (2005) The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis 64:309–310PubMedCrossRef Williams FMK, Cherkas LF, Spector TD et al (2005) The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis 64:309–310PubMedCrossRef
37.
Zurück zum Zitat Nguyen TV, Eisman JA, Kelly PJ et al (1996) Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 144:255–263PubMed Nguyen TV, Eisman JA, Kelly PJ et al (1996) Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 144:255–263PubMed
38.
Zurück zum Zitat Siris ES, Miller PD, Barrett-Connor E et al (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286:2815–2822PubMedCrossRef Siris ES, Miller PD, Barrett-Connor E et al (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286:2815–2822PubMedCrossRef
39.
Zurück zum Zitat Baron JA, Farahmand BY, Weiderpass E et al (2001) Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Arch Intern Med 161:983–988PubMedCrossRef Baron JA, Farahmand BY, Weiderpass E et al (2001) Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Arch Intern Med 161:983–988PubMedCrossRef
40.
Zurück zum Zitat Tuppurainen M, Kroger H, Honkanen R et al (1995) Risks of perimenopausal fractures - a prospective population-based study. Acta Obstet Gynecol Scand 74:624–628PubMedCrossRef Tuppurainen M, Kroger H, Honkanen R et al (1995) Risks of perimenopausal fractures - a prospective population-based study. Acta Obstet Gynecol Scand 74:624–628PubMedCrossRef
41.
Zurück zum Zitat Huopio J, Kroger H, Honkanen R et al (2000) Risk factors for perimenopausal fractures: a prospective study. Osteoporos Int 11:219–227PubMedCrossRef Huopio J, Kroger H, Honkanen R et al (2000) Risk factors for perimenopausal fractures: a prospective study. Osteoporos Int 11:219–227PubMedCrossRef
42.
Zurück zum Zitat Myking O, Aakvaag A, Digranes O (1987) Androgen-oestrogen imbalance in men with chronic alcoholism and fatty liver. Alcohol Alcohol 22:7–15PubMed Myking O, Aakvaag A, Digranes O (1987) Androgen-oestrogen imbalance in men with chronic alcoholism and fatty liver. Alcohol Alcohol 22:7–15PubMed
43.
Zurück zum Zitat Callaci JJ, Juknelis D, Patwardhan A et al (2004) The effects of binge alcohol exposure on bone resorption and biomechanical and structural properties are offset by concurrent bisphosphonate treatment. Alcohol Clin Exp Res 28:182–191PubMedCrossRef Callaci JJ, Juknelis D, Patwardhan A et al (2004) The effects of binge alcohol exposure on bone resorption and biomechanical and structural properties are offset by concurrent bisphosphonate treatment. Alcohol Clin Exp Res 28:182–191PubMedCrossRef
Metadaten
Titel
Bone density in relation to alcohol intake among men and women in the United States
verfasst von
K. S. Wosje
H. J. Kalkwarf
Publikationsdatum
01.03.2007
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 3/2007
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-006-0249-0

Weitere Artikel der Ausgabe 3/2007

Osteoporosis International 3/2007 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.