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Osteoporosis International

Erschienen in:

01.11.2008 | Original Article

Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae

verfasst von: W.-Q. Cui, Y.-Y. Won, M.-H. Baek, D.-H. Lee, Y.-S. Chung, J.-H. Hur, Y.-Z. Ma

Erschienen in: Osteoporosis International | Ausgabe 11/2008

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Abstract

Summary

This study investigated regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. The results demonstrate that age-related changes in trabecular microstructure significantly varied from different sub-regions of the proximal femur.

Introduction

We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.

Methods

A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA).

Results

Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb.N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb.N, SMI and DOA between superior and inferior trochanter.

Conclusions

Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.

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Titel: Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae
verfasst von: W.-Q. Cui
Y.-Y. Won
M.-H. Baek
D.-H. Lee
Y.-S. Chung
J.-H. Hur
Y.-Z. Ma
Publikationsdatum: 01.11.2008
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 11/2008
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0601-7

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Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae

Abstract

Summary

Introduction

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusions

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